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China Factory Supply High Purity Alpha-Calcium Ketoglutarate Monohydrate

Name: China Factory Supply High Purity Alpha-Calcium Ketoglutarate Monohydrate
Brand: ONERBIO
SKU: pr2606021208
Price: 10.4 USD
Availability: InStock

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Unit Price:

$10.4/KG FOB

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CAS No.:

71686-01-6

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Price valid (until):

2026-12-31

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Wuhan Oner Biotech Co.,Ltd.

Company Type:

Distributor

Location:

China

Qualification:

Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

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Product Description
Seller Information
Inquiry History

Description

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Product Name: Alpha-Calcium Ketoglutarate Monohydrate
CAS Number: 71686-01-6
Molecular Formula: C₅H₄CaO₅·H₂O
Molecular Weight: 202.18 g/mol
Appearance: White to off-white crystalline powder

Alpha-calcium ketoglutarate monohydrate is the calcium salt form of alpha-ketoglutaric acid, also known as 2-oxoglutaric acid. It is a white to off-white crystalline powder that is generally soluble in water and aqueous buffers, slightly soluble in polar organic media, and practically insoluble in nonpolar solvents. As a metabolic intermediate, the alpha-ketoglutarate anion plays a central role in the tricarboxylic acid cycle, amino acid metabolism. The calcium counterion contributes an essential mineral element. Functionally, this compound is used as a nutritional supplement ingredient, a cell culture additive, and a biochemical reagent. It may support cellular energy production, protein metabolism, nitrogen balance, and bone-related nutrition. In pharmaceutical and food research, it is investigated for metabolic support, muscle preservation, and formulation stability. It can also serve as a precursor in synthetic chemistry and as a buffering or mineral-delivery component in selected preparations. The monohydrate form provides convenient handling and storage. It should be kept in a cool, dry, well-ventilated place, protected from moisture, heat, direct sunlight, and strong oxidizing agents. Proper laboratory precautions, including gloves, eye protection, and ventilation, are recommended during handling. The material is typically assayed by titration or chromatographic methods, and it is available in research and industrial grades.

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ITEMS	STANDARDS		RESULTS
Description	White to almost white powder		White powder
UV absorbance ratio	A250/A260 A280/A260	0.41-0.49 2.03-2.71	0.45 2.14
PH	2.0-4.0		2.68
Loss on drying	≤5.0%		2.64%
Assay (UV)	≥98.0%		99.17%
Transmittance	≥98.5%		99.1%
Heavy metals	≤10ppm		＜10ppm
Purity (HPLC)	≥98.0%		99.6%
Conclusion	It complies to the standard

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.
Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).
Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).
Heavy Metals: NMT 20 ppm (typically lower for injectable grades).
Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).
Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.

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As a high-purity pharmaceutical intermediate, L-Tyrosine Ethyl Ester Hydrochloride is predominantly utilized in the chemical synthesis of bioactive peptides, dopamine analogs, and melanin precursors. Its excellent solubility profile makes it an ideal chiral building block for asymmetric synthesis and a critical substrate in enzymatic reactions. Available in purity grades of ≥98% (HPLC), it meets stringent requirements for R&D and cGMP manufacturing processes. Reliable supply ensures batch-to-batch consistency for long-term project scalability.

Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:

Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).
Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.
First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.
Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.

While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.

Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.

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ECHEMI Editorial Reference

2-Ketoglutaric acid calcium (Alpha-Ketoglutaric acid calcium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid calcium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid calcium is a reversible inhibitor of tyrosinase (IC50=15 mM)[1][2].
A family of compounds containing an oxo group with the general structure of 1,5-pentanedioic acid. (From Lehninger, Principles of Biochemistry, 1982, p442)

Certificates

Basic Info

Product Name:

Pentanedioic acid, 2-oxo-, calcium salt (1:1)

Other Name:

Pentanedioic acid,2-oxo-,calcium salt (1:1);Calcium 2-oxoglutarate

CAS No.:

71686-01-6

Molecular Formula:

C5H6O5.Ca

InChIKeys:

InChIKey=TWPAUQVDOXJGMP-UHFFFAOYSA-N

Molecular Weight:

184.16

Exact Mass:

183.968460

EC Number:

275-843-2

UNII:

95PE00B13W

HScode:

2918300090

Categories:

Nutrition Supplements

Characteristics

PSA:

97.3

Boiling Point:

345.6ºC at 760 mmHg

Flash Point:

177ºC

See More Pentanedioic acid, 2-oxo-, calcium salt (1:1) Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Pentanedioic acid, 2-oxo-, calcium salt (1:1) Safety Data Sheet 

Seller Information

Business Type:
Distributor

Main Products:
Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Location:
Changqing 5th Road, Jianghan District

Payment Terms:
TT against copy of documents

Average lead Time:
5

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2020

Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
France	Calcium 2-oxoglutarate	1 KG	Nov 27, 2023

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