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Cosmetic Preservative Material Hexamidine Diisethionate with High Quality

Name: Cosmetic Preservative Material Hexamidine Diisethionate with High Quality
Brand: ONERBIO
SKU: pr2606021225
Price: 10.26 USD
Availability: InStock

TDS 2 Inquiries

Unit Price:

$10.26/KG FOB

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CAS No.:

659-40-5

Grade:

Cosmetics Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Price valid (until):

2026-12-31

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Wuhan Oner Biotech Co.,Ltd.

Company Type:

Distributor

Location:

China

Qualification:

Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

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Product Description
Seller Information
Inquiry History

Description

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Product Name: Hexamidine Diisethionate
CAS Number: 659-40-5
Molecular Formula: C₂₄H₃₈N₄O₁₀S₂
Molecular Weight: 606.71 g/mol
Appearance: White to off-white crystalline powder

Description: Hexamidine diisethionate is the diisethionate salt of hexamidine, a symmetric aromatic diamidine. It is a white to off-white crystalline powder, odorless or nearly odorless, and is freely soluble in water, forming clear aqueous solutions. It is slightly soluble in polar organic solvents and practically insoluble in nonpolar solvents. The compound is stable under normal storage conditions but should be protected from moisture, excessive heat, and light. Aqueous solutions are generally stable over a wide pH range, though strongly alkaline conditions may reduce solubility or stability. Hexamidine diisethionate exhibits broad-spectrum antimicrobial activity against bacteria, yeasts, and dermatophytes. Its mechanism involves interaction with microbial cell membranes and disruption of essential cellular processes. It is widely used as a preservative and antiseptic in cosmetics, personal care products, and topical pharmaceutical preparations, often at low concentrations. It may be incompatible with anionic surfactants and certain oxidizing agents. It should be stored in a tightly closed container in a cool, dry, well-ventilated area. Handling requires standard laboratory precautions, including gloves, eye protection, and adequate ventilation. It is generally considered safe for topical use at recommended levels.

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ITEMS	STANDARDS		RESULTS
Description	White to almost white powder		White powder
UV absorbance ratio	A250/A260 A280/A260	0.41-0.49 2.03-2.71	0.45 2.14
PH	2.0-4.0		2.68
Loss on drying	≤5.0%		2.64%
Assay (UV)	≥98.0%		99.17%
Transmittance	≥98.5%		99.1%
Heavy metals	≤10ppm		＜10ppm
Purity (HPLC)	≥98.0%		99.6%
Conclusion	It complies to the standard

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.
Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).
Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).
Heavy Metals: NMT 20 ppm (typically lower for injectable grades).
Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).
Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.

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As a high-purity pharmaceutical intermediate, L-Tyrosine Ethyl Ester Hydrochloride is predominantly utilized in the chemical synthesis of bioactive peptides, dopamine analogs, and melanin precursors. Its excellent solubility profile makes it an ideal chiral building block for asymmetric synthesis and a critical substrate in enzymatic reactions. Available in purity grades of ≥98% (HPLC), it meets stringent requirements for R&D and cGMP manufacturing processes. Reliable supply ensures batch-to-batch consistency for long-term project scalability.

Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:

Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).
Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.
First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.
Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.

While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.

Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.

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ECHEMI Editorial Reference

White or slightly yellow powder, hygroscopic

Certificates

Basic Info

Product Name:

Hexamidine diisethionate

Other Name:

Ethanesulfonic acid,2-hydroxy-,compd. with 4,4′-[1,6-hexanediylbis(oxy)]bis[benzenecarboximidamide] (2:1);Ethanesulfonic acid,2-hydroxy-,compd. with 4,4′-(hexamethylenedioxy)dibenzamidine (2:1);Ethanesulfonic acid,2-hydroxy-,compd. with 4,4′-(hexamethylenedioxy)dibenzamidine;Benzamidine,4,4′-(hexamethylenedioxy)di-,diisethionate;Benzamidine,4,4′-(hexamethylenedioxy)di-,bis(2-hydroxyethanesulfonate);Benzenecarboximidamide,4,4′-[1,6-hexanediylbis(oxy)]bis-,bis(2-hydroxyethanesulfonate);2535RP;RP 2535;p,p′-(Hexamethylenedioxy)dibenzamide bis(β-hydroxyethanesulfonate);Hexamidine isethionate;Desomedine;Esomedina;Hexomedine;Ophtamedine;Hexamidine diisethionate;NSC 115848;Elestab HP 100;Elastab HP 100;Hexamethylenedioxy-4,4′-dibenzamidinebis(hydroxy-2-ethanesulfonate)

CAS No.:

659-40-5

Molecular Formula:

C20H26N4O2.2C2H6O4S

InChIKeys:

InChIKey=SUXLANSZRSDYOX-UHFFFAOYSA-N

Molecular Weight:

606.714

Exact Mass:

480.204254

EC Number:

211-533-5

UNII:

023XA5Z50L

HScode:

2942000000

Categories:

Anticorrosive

Characteristics

PSA:

284.16000

XLogP3:

4.76760

Appearance:

white powder or crystal

Melting Point:

246-247° (dec)

Boiling Point:

729ºC at 760 mmHg

Flash Point:

394.7ºC

Water Solubility:

Sparingly soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride

See More Hexamidine diisethionate Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H410 Very toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Hexamidine diisethionate Safety Data Sheet 

Seller Information

Business Type:
Distributor

Main Products:
Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Location:
Changqing 5th Road, Jianghan District

Payment Terms:
TT against copy of documents

Average lead Time:
5

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2020

Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Egypt	Hexamidine Diisethionate	1 KG	Sep 23, 2024
Egypt	Hexamidine di iseothionate	100 KG	Mar 28, 2024

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