Premium High Purity Amino Acid Threonine D(-)-allo-Threonine for Sale

Product Name: D(-)-allo-Threonine
CAS Number: 24830-94-2
Molecular Formula: C₄H₉NO₃
Molecular Weight: 119.12 g/mol
Appearance: White to off-white crystalline powder

D(-)-allo-Threonine, also known as (2R,3R)-2-amino-3-hydroxybutanoic acid, is a non-proteinogenic stereoisomer of the essential amino acid threonine. It is a chiral hydroxy amino acid that exists as a white to off-white crystalline powder at room temperature. The compound has a molecular formula of C4H9NO3 and a molecular weight of 119.12 g/mol. It is highly polar and readily soluble in water, slightly soluble in ethanol and methanol, and practically insoluble in nonpolar organic solvents such as ether and chloroform. In aqueous solution, it behaves as a zwitterion, containing both an amino group and a carboxyl group, and possesses an additional hydroxyl group on the beta-carbon. D(-)-allo-Threonine is optically active and exhibits a specific rotation distinct from L-threonine and D-threonine. It is stable under normal storage conditions but should be protected from excessive heat, moisture, and strong oxidizing agents. The compound is primarily used in biochemical research, chiral resolution, asymmetric synthesis, and peptide chemistry. It serves as a valuable building block for preparing modified peptides and pharmaceutical intermediates. Because it is not commonly incorporated into natural proteins, it is often employed as a stereochemical probe to study enzyme specificity and amino acid transport. It should be handled with standard laboratory precautions and stored in a cool, dry, tightly sealed container.

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

• Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.

• Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).

• Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).

• Heavy Metals: NMT 20 ppm (typically lower for injectable grades).

• Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).

• Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.