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Bioactive Citrus Flavonone for Advanced Nutraceutical Hesperidin Powder

Name: Bioactive Citrus Flavonone for Advanced Nutraceutical Hesperidin Powder
Brand: ONERBIO
SKU: pr2606021258
Price: 11.76 USD
Availability: InStock

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Unit Price:

$11.76/KG EXW

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CAS No.:

520-26-3

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Price valid (until):

2026-08-27

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Wuhan Oner Biotech Co.,Ltd.

Company Type:

Distributor

Location:

China

Qualification:

Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

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Product Description
Seller Information
History Price
Inquiry History

Description

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Chemical Name	Hesperidin (also known as Hesperetin 7-rutinoside)
CAS Number	520-26-3
Molecular Formula	C₂₈H₃₄O₁₅
Molecular Weight	610.56 g/mol
Physical Form	Fine powder
Color	Off-white to light yellow-brown
Odor	Odorless or slight characteristic odor
Solubility	Practically insoluble in water; freely soluble in pyridine and alkaline solutions; sparingly soluble in methanol and hot glacial acetic acid; insoluble in chloroform and ether
Melting Point	227–233 °C (decomposes)
Purity (Typical)	≥ 90% – 98% (HPLC, depending on grade)

Hesperidin is a naturally occurring flavanone glycoside predominantly found in the peel and membranous parts of citrus fruits, particularly oranges, lemons, and grapefruits. Chemically classified as a citrus bioflavonoid, it consists of the aglycone hesperetin linked to the disaccharide rutinose. This compound is widely recognized for its potent antioxidant properties, capable of scavenging free radicals and reducing oxidative stress at the cellular level.

In physiological applications, hesperidin has been extensively studied for its capacity to support capillary integrity, improve venous tone, and promote healthy microcirculation, making it a key ingredient in formulations for vascular and circulatory health. Additionally, it exhibits anti-inflammatory, anti-allergic, and mild cholesterol-lowering activities. As a dietary supplement ingredient, hesperidin is valued for its synergistic effects when combined with vitamin C, enhancing overall bioavailability and immune support. Its poor aqueous solubility often drives the development of advanced delivery systems or water-soluble derivatives (such as hesperidin methyl chalcone) to broaden its functional applications in nutraceuticals, functional foods, and cosmetic products. Standardized hesperidin extracts are typically assayed by high-performance liquid chromatography (HPLC) to ensure consistent potency and quality.

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ITEMS	STANDARDS		RESULTS
Description	White to almost white powder		White powder
UV absorbance ratio	A250/A260 A280/A260	0.41-0.49 2.03-2.71	0.45 2.14
PH	2.0-4.0		2.68
Loss on drying	≤5.0%		2.64%
Assay (UV)	≥98.0%		99.17%
Transmittance	≥98.5%		99.1%
Heavy metals	≤10ppm		＜10ppm
Purity (HPLC)	≥98.0%		99.6%
Conclusion	It complies to the standard

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.
Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).
Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).
Heavy Metals: NMT 20 ppm (typically lower for injectable grades).
Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).
Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.

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As a high-purity pharmaceutical intermediate, L-Tyrosine Ethyl Ester Hydrochloride is predominantly utilized in the chemical synthesis of bioactive peptides, dopamine analogs, and melanin precursors. Its excellent solubility profile makes it an ideal chiral building block for asymmetric synthesis and a critical substrate in enzymatic reactions. Available in purity grades of ≥98% (HPLC), it meets stringent requirements for R&D and cGMP manufacturing processes. Reliable supply ensures batch-to-batch consistency for long-term project scalability.

Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:

Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).
Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.
First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.
Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.

While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.

Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.

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ECHEMI Editorial Reference

It is light yellow crystalline powder with melting point being 258-262 °C (soften at 252 °C). It is easily soluble in pyridine, sodium hydroxide solution; soluble in dimethyl formamide; slightly soluble in methanol and hot glacial acetic acid; very slightly soluble in ether, acetone, chloroform and benzene.1g of this product can be dissolved in 50L water. It is odorless and tasteless. light brown powder
Hesperidin is a disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as a mutagen. It is a disaccharide derivative, a member of 3'-hydroxyflavanones, a dihydroxyflavanone, a monomethoxyflavanone, a flavanone glycoside, a member of 4'-methoxyflavanones and a rutinoside. It derives from a hesperetin.|Hesperidin is a flavan-on glycoside found in citrus fruits.|A flavanone glycoside found in CITRUS fruit peels.

Certificates

Basic Info

Product Name:

Hesperidin

Other Name:

4H-1-Benzopyran-4-one,7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-,(2S)-;Hesperidin;4H-1-Benzopyran-4-one,7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-,(S)-;Flavanone,3′,5,7-trihydroxy-4′-methoxy-,7-(6-O-α-L-rhamnosyl-D-glucoside);(2S)-7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one;Cirantin;Hesperidoside;Hesperetin 7-rutinoside;Hesperidine;Hesperetin 7-rhamnoglucoside;NSC 44184;(2S)-Hesperidin;Atripliside B;Hesperetin 7-O-rutinoside;Hesperitin 7-O-rutinoside;15512-51-3;16643-24-6;17654-22-7;28283-75-2;30927-97-0;32737-61-4;106904-63-6;960582-50-7;1817614-33-7

CAS No.:

520-26-3

Molecular Formula:

C28H34O15

InChIKeys:

InChIKey=QUQPHWDTPGMPEX-QJBIFVCTSA-N

Molecular Weight:

610.56

Exact Mass:

610.56

EC Number:

208-288-1

UNII:

E750O06Y6O

DSSTox ID:

DTXSID9044328

HScode:

29389090

Categories:

Nutrition Supplements

Characteristics

PSA:

234

XLogP3:

-1.1

Appearance:

light brown Powder

Density:

1.3290 (rough estimate)

Melting Point:

262 °C

Boiling Point:

930.1°C at 760 mmHg

Flash Point:

305.5ºC

Refractive Index:

1.695

Water Solubility:

Insoluble in water. soluble in organic solvents such as DMSO.

Storage Conditions:

2-8°C

Specific rotation:

-76 º (c=2,pyridine)

Collision Cross Section:

227 Å² [M+Na]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

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Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Hesperidin Safety Data Sheet 

Seller Information

Business Type:
Distributor

Main Products:
Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Location:
Changqing 5th Road, Jianghan District

Payment Terms:
TT against copy of documents

Average lead Time:
5

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2020

Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
Weekly Price

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Inquiry History

7 Inquiries

Country	Product	Purchase Quantity	Date Posted
United Kingdom	Hesperidin	25 KG	Jun 1, 2026
Egypt	Hesperidin	400.00 KG	Jan 29, 2026
Mexico	Hesperidin	3 KG	Sep 16, 2025
India	Hesperedin	2.00 KG	Feb 26, 2025
Turkey	Hesperedin	1 TON	Oct 8, 2024
Brazil	Hesperidin	50 MT	Nov 22, 2024
India	hesperidin	10	Apr 22, 2024

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Bioactive Citrus Flavonone for Advanced Nutraceutical Hesperidin Powder

Product Description

Seller Information

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