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• Active Substance: Kartogenin is a synthetic, small-molecule organic compound.
• Chemical Structure: Its chemical name is 2-[(4-phenylbiphenyl-4-yl)carbamoyl]benzoic acid.
• Molecular Class: Unlike peptide-based therapies, it is a non-protein ligand that functions by binding to specific cellular proteins (such as calmodulin) to modulate intracellular signaling pathways .

Mechanism of Action

• CBFβ–RUNX1 Pathway Modulation: The molecule binds to calmodulin, which allosterically regulates the interaction between core-binding factor subunit beta (CBFβ) and runt-related transcription factor 1 (RUNX1) .
• Stem Cell Differentiation: By modulating this signaling pathway, Kartogenin induces bone marrow mesenchymal stem cells (BMMSCs) to differentiate specifically into chondrocytes .
• Tissue Regeneration: This process facilitates the restoration of the cartilage extracellular matrix, addressing the root cause of degeneration in articular joints.

Research Advantages

• High Specificity: It selectively targets the chondrogenic lineage without inducing differentiation into osteoblasts (bone cells) or adipocytes (fat cells) at therapeutic concentrations .
• Pharmacokinetic Properties: As a small molecule, it exhibits superior tissue penetration and stability compared to protein-based biologics or gene therapy vectors.
• Drug Delivery Compatibility: It is frequently encapsulated in biodegradable microspheres (such as PLGA) or hydrogels to achieve sustained release within the joint cavity, thereby maximizing therapeutic efficacy while minimizing systemic loss .
• Homing Enhancement: It enhances the homing capacity of endogenous host stem cells, allowing for cartilage regeneration without the need for complex cell transplantation procedures .

Target Population

• Scientific Research: Primarily intended for in vitro and in vivo laboratory investigations focusing on cartilage tissue engineering and stem cell biology .
• Therapeutic Development: Serves as a candidate for developing interventions targeting articular cartilage injuries and degenerative joint diseases (such as osteoarthritis), which are common health problems causing disability across all age groups .

1. How to make an order?
Send me message and let me know what you need with quantity , then i will calculate to you

2. What's the lead time and shipping ways?
We will delivery to the package by UPS, FEDEX, DHL paket and YANWEN express to you after receive your payment, it would take around 5-15 days to your address.

3. How do i keep the peptides when i receive it ?
Peptides in the form of lyophilized powder can be transported at room temperature by vacuum packaging, while polypeptides in the dissolved state need to be refrigerated at 2°C - 8°C. For long-term storage, peptides should be stored in the form of lyophilized powder store at -20°C or -80°C in a sealed container with desiccant, which can avoid the degradation of peptides to the greatest extent.

4. What's the payment methods?
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