PE 22-28|Premium in stock

  Product Detail  

• Basic Information
• Name: PE 22-28 (Acetate Salt)
• Alias: Mini‑Spadin, TREK‑1 Inhibitor Peptide, PE‑22‑28
• Amino Acid Sequence: Gly‑Val‑Ser‑Trp‑Gly‑Leu‑Arg (GVSWGLR)
• Molecular Formula: C₃₅H₅₅N₁₁O₉
• Molecular Weight: 773.89 Da
• CAS No: 1801959‑12‑5
• Appearance: White/off‑white sterile lyophilized powder
• Solubility: Freely soluble in sterile water, PBS, or isotonic saline
• Storage: -20°C (long‑term), 2–8°C (short‑term ≤7 days); avoid repeated freeze‑thaw; shelf life: 24 months

Core Mechanism of Action (For Research Only)

• Primary Target: Selective, high‑affinity inhibitor of TREK‑1 (K₂P2.1/KCNK2) two‑pore domain potassium channel.
• Potency: IC₅₀ = 0.1–0.12 nM (HEK293 cells expressing human TREK‑1).
• Selectivity: Highly specific for TREK‑1 over TREK‑2, TRAAK, TRESK, TASK‑1, and hERG channels.
• Neuronal Excitability: Blocks TREK‑1‑mediated K⁺ efflux, reduces neuronal hyperpolarization, prolongs depolarization, and enhances firing in serotonergic raphe nuclei.
• Downstream Signaling: Activates CREB and upregulates BDNF and PSD‑95, driving hippocampal neurogenesis and synaptogenesis.
• Behavioral Effects: Produces rapid antidepressant‑like activity in rodent models (forced swim, tail suspension, novelty‑suppressed feeding) within 4 days.
• Neuroprotection: Preserves dopaminergic neurons and mitigates post‑ischemic depressive behavior in stroke models.

Premium Grade Specifications & Quality

• Purity: ≥99.0% (HPLC)
• Formats: 5 mg/vial, 10 mg/vial (standard lyophilized)
• QC Standards:
  • Single impurity ≤1.0%; total impurities ≤2.0%
  • Endotoxin <0.5 EU/mg; sterile filtered
  • Heavy metals ≤10 ppm; Arsenic ≤2 ppm
  • Moisture ≤1.0%; full COA provided
• Stock: In stock for immediate shipment

Usage & Handling

• For laboratory research only; NOT for human/veterinary clinical use
• Reconstitute with sterile water/PBS to desired concentration
• Short‑term storage: 2–8°C (≤7 days); long‑term: -20°C
• Avoid repeated freeze‑thaw cycles