Semax (MEHFPGP) 99% High Purity Synthetic Heptapeptide Multiple Sizes: 5 mg / 10 mg per Vial

Product Description – The Science of Semax in Skin Health & Neurocosmetic Research
Semax is a synthetic heptapeptide with the amino acid sequence Met‑Glu‑His‑Phe‑Pro‑Gly‑Pro (MEHFPGP) . It was first developed at the Institute of Molecular Genetics, Russian Academy of Sciences, as a fragment analogue of adrenocorticotropic hormone (ACTH(4‑10)) and has been a focus of neurobiological research for over three decades [8†L3-L8][9†L2-L3]. The peptide is structurally non‑hormonal in the classical endocrine sense; it lacks the steroidogenic activity of full‑length ACTH but retains significant influences on neurotrophic signalling, adaptive stress responses and cellular metabolism [12†L14-L17][8†L13-L14].

While Semax is most widely recognised for its nootropic and neuroprotective research applications, a growing body of evidence suggests its relevance extends beyond the central nervous system. The skin is a neuro‑endocrine organ that shares many signalling pathways with the brain, and emerging interest in neurocosmetics has highlighted peptides like Semax as promising candidates for topical formulations that address stress‑induced skin ageing, barrier dysfunction and inflammatory sensitivity. The following sections summarise the core mechanisms that form the scientific basis for exploring Semax in skin research.

Modulation of Neurotrophic Signalling (BDNF/TrkB)
One of the most well‑documented cellular actions of Semax is its ability to increase levels of brain‑derived neurotrophic factor (BDNF) , a protein that plays a fundamental role in cellular survival, adaptive plasticity and stress resilience [8†L18-L20][9†L8-L15]. BDNF is not confined to the nervous system; its receptors are also expressed in human skin cells, including keratinocytes and fibroblasts, where they influence wound healing, inflammatory tone and barrier integrity.

In a study examining Semax binding and activity, researchers identified specific, saturable and reversible binding sites for the peptide in rat basal forebrain, with a mean dissociation constant (KD) of 2.4 ± 1.0 nM, indicating high‑affinity interactions [9†L19-L22]. Sandwich immunoenzymatic analysis further revealed that Semax applied intranasally at 50 μg/kg and 250 μg/kg resulted in a rapid increase in BDNF protein levels in the basal forebrain within 3 hours [9†L23-L25]. The cognitive and adaptive effects exerted by Semax have been proposed to be associated, at least in part, with this elevated BDNF signalling [9†L27-L29].

More recent cellular work has shown that Semax modulates not only BDNF expression but also the levels of its high‑affinity receptor TrkB, as well as melanocortin‑4 receptors (MCR4) [8†L22-L24]. The study suggests that Semax affects brain functions by modulating the expression and activation of the BDNF/TrkB system [8†L30-L31]. For topical research, this neurotrophic mechanism offers a pathway to support the skin’s own adaptive and repair‑orientated signalling under conditions of cellular stress.

Mitochondrial Bioenergetics and Cellular Resistance
At the cellular level, Semax has been shown to sustain mitochondrial function and improve the ability of cells to utilise energy substrates, both under basal conditions and in the presence of stressors [8†L31-L33]. Research on differentiated neuroblastoma cells demonstrated that cells grown in the presence of Semax exhibited higher mitochondrial membrane potential and increased mitochondrial mass compared to control cells [8†L24-L27]. This enhanced bioenergetic status was associated with greater resistance to various forms of stress, suggesting that Semax may equip cells with a more robust metabolic foundation.

This bioenergetic effect has important implications for skin biology. Mitochondrial dysfunction is a key driver of both intrinsic (chronological) and extrinsic (photo‑induced) skin ageing, leading to reduced ATP production, increased reactive oxygen species (ROS) and activation of inflammatory pathways. By supporting mitochondrial health, Semax could in principle help preserve the functional capacity of dermal fibroblasts and epidermal keratinocytes, thereby aiding collagen integrity and barrier resilience.

1. Ultra-High Purity

Each batch is synthesized and purified to >99% purity (HPLC), ensuring reliable and reproducible results in sensitive experiments.
2.Accurate Dosing & Consistency
Our peptides are precisely weighed and vacuum-sealed under sterile conditions. Batch-to-batch consistency is rigorously maintained.
3.Endotoxin-Free & Sterile Processing
Manufactured in a cleanroom environment, our peptides are free from endotoxins, microbial contamination, and other impurities that could interfere with cell-based or in vivo studies.

Sales manager:  Eira

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1. Advanced Manufacturing Capabilities

Cutting-Edge Facilities: High-precision equipment ensuring purity and bioactivity.

Scalable Production: From milligram-scale research peptides to multi-kilogram industrial batches.

2. Innovation & Customer Commitment

Reliable Supply Chain: Competitive pricing & timely global delivery.

Global Reach: Trusted by researchers, pharmaceutical firms & industrial clients worldwide.

Q1: May I get one sample before placing order?
Re: Yes, Sample are available. For normal products, samples are for free and you just need to bear the freight; For those high value products, you just need to freight and certain product cost. When we both cooperate for some times or when you are our VIP customer, free sample will be offered when you need.
Q2: Which payment is available for your company?
Re: T/T, PayPal,bank transfer etc. You can choose the one which is convenient for you.
Q3: How and when can I get my goods after payment?
Re: For small quantity products, they will be delivered to you by international courier(DHL, FedEx, TNT etc.) or by air. Usually it will cost 5-7days that you can get the goods after delivery.For large quantity products, shipping by see is worthwhile.It will cost 15 to 30 days to come to your destination port, which depends on where the port is.
Q4: Is there any possible to use my appointed label or package?
Re: Yes. If needed, we'd lik.

1. Expertise in Peptide Synthesis
Extensive Experience: 7 Years of expertise in synthetic peptide development.
Skilled Team: Experts in solid-phase and liquid-phase synthesis.
2. Advanced Manufacturing Capabilities
Cutting-Edge Facilities: High-precision equipment ensuring purity and bioactivity.
Scalable Production: From milligram-scale research peptides to multi-kilogram industrial batches.
3. Innovation & Customer Commitment
Reliable Supply Chain: Competitive pricing & timely global delivery.
Global Reach: Trusted by researchers, pharmaceutical firms & industrial clients worldwide.
4. Ultra-High Purity
Each batch is synthesized and purified to >99% purity (HPLC), ensuring reliable and reproducible results in sensitive experiments.
5.Accurate Dosing & Consistency
Our peptides are precisely weighed and vacuum-sealed under sterile conditions. Batch-to-batch consistency is rigorously maintained.
6.Endotoxin-Free & Sterile Processing
Manufactured in a cleanroom environment, our peptides are free from endotoxins, microbial contamination, and other impurities that could interfere with cell-based or in vivo studies.

Why Choose Our Peptides?

• Quality Assured: Sourced from trusted manufacturers with reliable global distribution, ensuring consistency and potency .
• Holistic Support: Complements weight management programs, metabolic health goals, and sleep apnea treatment plans—addressing root causes for lasting impact .
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• Why Partner with us?

  
  Quality Assurance:

  Manufactured in GMP-certified facilities with full traceability and regulatory-aligned documentation.
  

  Flexible Supply:

  Available in multiple formats. Consistent lead times with flexible production capacity.
  

  Competitive Edge:

  Factory-direct pricing with volume discounts; stable supply chain to meet your market demand.
  

  Technical Support:

  Full documentation and formulation guidance.