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Gelsemiol

Name: Gelsemiol
Brand: Cuicheng Bio
SKU: pr2606081161
Price: 180000 USD
Availability: InStock

Unit Price:

$180000-200000/MT FOB

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CAS No.:

110414-77-2

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

5mg

Price valid (until):

2026-07-08

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information

Description

Gelsemiol is a naturally occurring iridoid glucoside/monoterpenoid non-alkaloid compound. Unlike the highly toxic indole alkaloids commonly found in the same genus (such as gelsemine or koumine), gelsemiol belongs to the cyclopentanoid pyran ring framework. Its primary functions include enhancing neurite outgrowth, providing neuroprotection, modulating insulin secretion, and acting as a botanical chemical defense agent.

1. Core Neuropharmacological and Neuroregenerative Functions

Potentiation of Nerve Growth Factor (NGF): In neurodegenerative and neurorestorative research, gelsemiol functions as a potent NGF enhancer. It has been shown to significantly accelerate differentiation and stimulate neurite outgrowth/elongation in PC12D cell models. This structural modification capability makes it a valuable lead scaffold for investigating the repair of damaged neurons in diseases like Alzheimer's or Parkinson's.
Potential Central Nervous System Modulation: While the primary analgesic effects of Gelsemium plants are attributed to their alkaloid content, computer-aided molecular docking and screening show that iridoid components like gelsemiol can interface with glycine receptors (GlyR) and $GABA_{A}$ receptors. This interaction helps lower neuronal excitability, potentially contributing to peripheral pain relief, the alleviation of neuropathic pain, and anti-anxiety effects.

2. Metabolic and Endocrine Regulation

Promotion of Glucose-Stimulated Insulin Secretion (GSIS): In endocrine and metabolic models (such as those isolating the compound from Lyonia ovalifolia), gelsemiol has been evaluated for its anti-diabetic potential. It significantly enhances insulin secretion in response to high glucose levels without displaying cytotoxic side effects, marking it as a natural insulin secretagogue candidate for blood sugar control studies.

3. Ecological and Botanical Defense Mechanics

Plant Chemical Defense Matrix: Gelsemiol is widely distributed in the stems and leaves of plants within the Gelsemium genus (such as Gelsemium sempervirens and Gelsemium elegans) as well as certain Verbena species. Operating as a secondary metabolite, it serves as a chemical defense weapon to deter herbivorous insects, suppress larval feeding, and shield the host plant against localized microbial or fungal pathogens.

4. Synthetic Chemistry and Laboratory R&D

Chiral Structural Scaffold: Gelsemiol features a highly compact, fused bicyclic core with multiple continuous chiral centers. Because of its complex structure and unique bioactivities, it serves as a challenging and valuable chiral building block for organic synthesists studying radical cascade reactions, skeletal rearrangements, and the biosynthetic pathways of iridoids.

Basic Info

Product Name:

Gelsemiol

Other Name:

Gelsemiol;2H-Cyclopenta[b]furan-2-one,hexahydro-3,4-bis(hydroxymethyl)-5-methyl-, (3R,3aS,4R,5S,6aS)-

CAS No.:

110414-77-2

Molecular Formula:

C10H16O4

InChIKeys:

FNYPTQQTJGQJNF-BGKGJTHRSA-N

Molecular Weight:

200.234

Exact Mass:

200.105

Categories:

Iridoid Derivatives

Characteristics

PSA:

66.8

XLogP3:

0.5

Density:

1.194±0.06 g/cm3(Predicted)

Boiling Point:

407.0±10.0 °C(Predicted)

See More Gelsemiol Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Gelsemiol Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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Gelsemiol

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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