Mazdutide is an innovative therapeutic agent with the following details:
English name: Mazdutide
CAS number: 2259884-03-0
Mazdutide is a GLP-1R/GCGR dual receptor agonist developed by Innovent Biologics, intended for the long-term weight management of adult patients with obesity or overweight.
Mechanism of Action
Mazdutide innovatively adopts a dual receptor agonist mechanism. On one hand, it activates GLP-1R to promote insulin secretion, suppress appetite, and delay gastric emptying, thereby reducing food intake. On the other hand, it activates GCGR to promote fat oxidation and energy expenditure. This two-pronged approach enhances the ability to reduce weight and regulate metabolism.
Weight Loss Efficacy
In the Phase II clinical trial of Mazdutide, patients in the 3mg, 4.5mg, and 6mg Mazdutide groups (administered once weekly) achieved an average weight reduction of 7.2%, 10.6%, and 11.6% respectively after 24 weeks of treatment. Results from the Phase III GLORY-1 trial showed that during the 48-week treatment period, the 6mg Mazdutide group had an average weight loss of 14.01%, while the placebo group only had a weight loss of 0.30%.
Improvement of Metabolic Indicators
Mazdutide not only effectively reduces weight but also comprehensively improves metabolic indicators. For example, in the Phase III clinical trial, the 6mg Mazdutide group saw an average reduction of 8.56mmHg in systolic blood pressure, a decrease of 0.65mmol/L in triglycerides, and a significant reduction in uric acid levels. Additionally, it showed a significant improvement effect on fatty liver, which can effectively reduce the pressure on the cardiovascular system and lower the risk of obesity-related complications.
Target Population
It is suitable for patients with simple obesity (BMI ≥ 28) and patients with a BMI of ≥ 24 who have one or more comorbidities, such as hyperglycemia, hypertension, dyslipidemia, fatty liver, and obstructive sleep apnea.
——Product Application——
- 1.Helps slow food leaving your stomach
- 2.Helps prevent your liver from making too much sugar
- 3.Helps the pancreas produce more insul when your blood sugar levels are high
- 4.Can help control blood glucose
- 5.Can reduce hyperglycemia, especially after meals
- 6.Can reduce fasting insul and fasting glucose
- 7.Can decrease appetite and caloric intake, while inhibiting weight gain
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——Company Profile——
JoySlimTechnolog Co., Ltd. is a modern advanced enterprise specializing in production and exportation of APIs, Pharmaceutical intermediates, plant extracts etc. Our products are widely used in medicine, health care products, cosmetics, nutritional supplements and food additives areas. Our factory covers an area of 95 acres, the proposed construction of the plant will be GMP standards, the factory environment clean and tidy, rational layout, with large and medium-sized production workshop and repocessed shop. It is equipped with advanced equipment quality inspection and research center. Those products of both quality and technical content have reached the domestic advanced level. Since its establishment, the company has attached great importance to the team training and technical reform. Our modern production equipment guarantees for a fast and effective production with a superior degree of accuracy throughout the whole production line, everything is done in-house, processing, extraction, packaging and transportation of all links, ensuring maximum quality and efficiency. We are constantly research and development new ingredients and innovative new products, have earned the respect & Admiration from the worldwide customers. After years of continuous development, company has been accumulated rich experience in international trade and customer resources, established a stable customer base and perfect marketing service network. In addition, the company has established long-term technical cooperation with experts and professors from many universities and research institutes in the province.
——Shipping——
Peptide Storage Guidelines: General Tips
When storing peptides, remember to:
• Store peptide in a cold, dry, dark place
• Avoid repeated freezing and thawing of peptide
• Avoid overexposure to the air
• Avoid light exposure
• Avoid storing peptides in solution long term
• Aliquot peptide according to experimental requirements
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