TB500 CAS 885340-08-9 | High Purity Synthetic Peptide | Promotes Angiogenesis, Endothelial Differentiation & Anti-Inflammation for Lab Use

Guangzhou Boyuan Outdoor Products Co., Ltd. is a trading company headquartered in Guangzhou, one of southern China's most prominent commercial and logistics hubs. Leveraging the city's well-established supply chain infrastructure and international trade channels, the company has evolved from its original focus on outdoor consumer goods into a specialized supplier of high-purity biochemical reagents and peptide derivatives. While the company retains "Outdoor Products" in its registered name, its current core business centers on providing stable, non-hazardous, and laboratory-grade peptide derivatives to qualified research institutions, universities, and commercial laboratories worldwide.

Boyuan operates under a clear and responsible business philosophy: professionalism, consistency, and traceability. All products offered by the company are positioned strictly as general chemical reagents and laboratory research materials. They are not classified as pharmaceuticals, medical devices, hazardous chemicals, or products intended for human therapeutic, diagnostic, or preventive applications. The company strictly adheres to national and international regulations governing the trade and logistics of non-hazardous chemical products, ensuring that every step—from procurement and quality inspection to warehousing and domestic or international shipping—remains compliant, safe, and fully traceable.

TB500 is a high-purity synthetic peptide fragment derived from the naturally occurring protein Thymosin Beta-4 (Tβ4), specifically corresponding to the active 17-amino acid N-terminal region with the core sequence Ac-LKKTETQ, which retains the key biological functions of the parent molecule while offering enhanced synthetic accessibility and stability for laboratory research applications. This peptide operates primarily through its high-affinity binding to globular actin (G-actin), thereby regulating the dynamic equilibrium between G-actin and filamentous actin (F-actin) within the cytoskeleton, a mechanism that profoundly influences cell morphology, adhesion, migration, and intracellular mechanical signaling. As a result, TB500 has become a valuable research tool in the fields of regenerative medicine, cell biology, and tissue engineering, where it is used to study fundamental processes such as wound healing, angiogenesis, inflammation modulation, and cell survival. Regarding its biological properties, TB500 promotes the migration of endothelial cells, which is a critical step in the formation of new blood vessels (angiogenesis), thereby supporting oxygen and nutrient delivery to healing tissues; it also downregulates key pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6), creating a balanced inflammatory microenvironment conducive to repair rather than fibrosis; additionally, it exhibits anti-apoptotic effects by preserving cell viability under stress conditions, which has been observed in various cell types such as cardiomyocytes, neurons, and epithelial cells. In terms of research applications, TB500 has been utilized in laboratory models of cutaneous wound healing where it accelerates re-epithelialization and granulation tissue formation, in corneal injury models where it promotes epithelial repair without inducing abnormal vascularization, in cardiac ischemia research where it reduces infarct size and improves capillary density in the peri-infarct zone, in neurological studies where it supports axonal sprouting and neuronal survival following traumatic injury, in tendon and ligament repair models where it stimulates tenocyte proliferation and collagen deposition, and in stem cell migration studies where it acts as a chemoattractant for endogenous progenitor cell populations. From a quality perspective, TB500 is supplied as a white to off-white lyophilized powder with a purity of 98% or higher as determined by HPLC, with each batch accompanied by mass spectrometry (MS) validation of the correct molecular weight (approximately 969.1 g/mol for the free base), low endotoxin levels (≤1.0 EU/mg), and compliance with ICH Q3C guidelines for residual solvents, making it suitable for a wide range of in vitro and in vivo research protocols. For reconstitution and handling, the lyophilized powder should be allowed to reach room temperature, centrifuged briefly, and then dissolved in sterile water or sterile bacteriostatic water to achieve a typical concentration of 1–2 mg/mL, with gentle swirling rather than vortexing to avoid denaturation; the reconstituted solution is stable for up to one month at 4°C when protected from light, while the lyophilized powder remains stable for 12–24 months when stored at -20°C in a desiccated, light-protected environment, and repeated freeze-thaw cycles should be avoided to maintain peptide integrity. In summary, TB500 (CAS 885340-08-9) is a well-characterized synthetic peptide fragment that offers researchers a reliable tool for investigating actin-mediated cytoskeletal dynamics, cell migration, angiogenesis, inflammation control, and tissue regeneration across multiple biological systems, with rigorous quality control ensuring batch-to-batch consistency and reproducibility.

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