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2-Methoxystypandrone

Name: 2-Methoxystypandrone
Brand: Cuicheng Bio
SKU: pr2606104167
Price: 140000 USD
Availability: InStock

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CAS No.:

85122-21-0

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

5mg

Price valid (until):

2026-07-11

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Description

2-Methoxystypandrone (also known as MAM or 2-methoxy-6-acetyl-7-methyljuglone) is a naturally occurring bioactive naphthoquinone derivative primarily extracted from the roots of Polygonum cuspidatum (Asian knotweed). In biomedical and pharmacological research, it functions as a potent multi-pathway inhibitor with significant anti-inflammatory, anticancer, neuroprotective, and anti-aging capabilities.

1. Dual Inhibitor of STAT3 and NF-κB (Anti-Inflammatory & Anticancer)

Its primary biochemical function is the simultaneous suppression of two major inflammatory pathways:

JAK2/STAT3 Pathway: It directly inhibits Janus kinase 2 (JAK2) in vitro, blocking interleukin-6 (IL-6)-induced and constitutively active STAT3 signaling. This stops the gene transcription required for tumor growth and survival.
IKK/NF-κB Pathway: It acts as an IκB kinase (IKK) inhibitor, preventing the phosphorylation of IκB-α and subsequent NF-κB activation. This shuts down downstream tumor necrosis factor-alpha (TNF-α)-mediated inflammatory loops.
2. Induction of Tumor Cell Apoptosis

Because it deactivates cell-survival signaling (NF-κB/STAT3), 2-methoxystypandrone forces malignant cells into programmed cell death:
- In human cancer profiles (such as leukemia Jurkat T cells), it downregulates anti-apoptotic proteins like Bcl-2 and Bcl-xl while upregulating the pro-apoptotic protein BAX.
- It decreases mitochondrial membrane potential and triggers lethal reactive oxygen species (ROS) accumulation strictly within cancer populations to halt cell-cycle progression.
In neurology models, the compound functions as a strong cerebroprotective agent against ischemic damage and neurodegenerative conditions like Parkinson's disease:
Ischemic Stroke Efficacy: It diminishes the size of cortical infarctions. By blocking NF-κB, it curbs local neuroinflammation and oxidative stress to preserve the structural integrity of the Blood-Brain Barrier (BBB).
Neurogenesis: It inactivates GSK3β, which upregulates β-catenin signaling and triggers endogenous neurogenesis (growth of new neurons) near the hippocampus and subventricular zones.
Mitochondrial Rescue: It protects neuronal cells (like PC12 models) against 6-OHDA-induced neurotoxicity by stabilizing mitochondrial electrochemical gradients and mitigating apoptotic cascades.

ECHEMI Editorial Reference

Solid
Solid
2-Methoxystypandrone is a naphthoquinone.

Basic Info

Product Name:

2-Methoxystypandrone

Other Name:

1,4-Naphthalenedione,6-acetyl-5-hydroxy-2-methoxy-7-methyl-;6-Acetyl-5-hydroxy-2-methoxy-7-methyl-1,4-naphthalenedione;2-Methoxystypandrone;2-Methoxy-6-acetyl-7-methyljuglone;Naphthoquinone (2-methylstipandrone

CAS No.:

85122-21-0

Molecular Formula:

C14H12O5

InChIKeys:

InChIKey=SSHJHOVVYKCJJI-UHFFFAOYSA-N

Molecular Weight:

260.24208

Exact Mass:

260.24

DSSTox ID:

DTXSID10234258

Categories:

Quinone Ring

Characteristics

PSA:

80.7

XLogP3:

1.9

Density:

1.37±0.1 g/cm3(Predicted)

Melting Point:

187 °C

Boiling Point:

530.3ºC at 760mmHg

Flash Point:

206.5ºC

Refractive Index:

1.604

See More 2-Methoxystypandrone Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 2-Methoxystypandrone Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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2-Methoxystypandrone

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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