1. Product Overview
ARA-290 (also known as Cibinetide) is a synthetic 11-amino-acid small-molecule peptide derived from the B-helix surface functional fragment of erythropoietin (EPO) and optimized via structural engineering. Supplied as lyophilized powder with high purity and stability, it serves as a benchmark research tool peptide targeting the non-hematopoietic pathways of EPO, for in vitro scientific research only. 2. Key Features
- Receptor Selectivity: Specifically activates the EPO/CD131 heterodimeric receptor (IRR) without binding to the classical EPOR homodimer, posing no hematopoietic activity-related risks with high safety.
- Functional Properties: Exhibits anti-inflammatory, anti-apoptotic, neuroprotective and tissue-repair activities; capable of crossing the blood-brain barrier with strong tissue penetration.
- High Stability: Chemically stable; lyophilized form facilitates long-term storage; aqueous solution maintains stable activity if prepared fresh.
3. Research Applications
For in vitro research use only, suitable for the following areas:
- Neuroprotection and repair mechanism studies (e.g., nerve injury, neurodegenerative disease models)
- Inflammatory regulation pathway research (e.g., NF-κB pathway, pro-inflammatory factors such as TNF-α/IL-6)
- Tissue damage repair and regeneration research (e.g., vascular and endothelial cell protection)
- Pain modulation mechanism research (e.g., neuropathic pain models)
- Innate repair receptor (IRR) signaling pathway exploration
4. Notes
- For in vitro laboratory use only by professional researchers; not for human/animal therapeutic use or other non-research applications.
- Highly hygroscopic and light-sensitive; avoid humid environments and strong light during handling; seal immediately after use.
- Aqueous solution has poor stability; prepare and use immediately to avoid activity degradation from prolonged storage.
- Handle with care during transportation to prevent package damage, moisture absorption or contamination.
| Items | Specifications |
| CAS No | 1208243-50-8 |
| Product Name | ARA-290 |
| Appearance | White lyophilized powder |
| Specification | 10 pieces per box |
| Origin | Guangzhou |
| Purity | ≥98% HPLC |
| Storage | Keep sealed, cool, dry and away from light |
-
1. Pre-operation Preparation
This product is for in vitro laboratory research and shall only be handled by professional researchers. Clean the working area in advance and keep it clean, dry and well ventilated to avoid cross-contamination. Prepare experimental containers, liquid handling tools, solvents and protective equipment. All utensils shall be cleaned, sterilized and cooled before use.
Wear lab coat, gloves and goggles during operation to prevent direct contact of powder and solution with skin, eyes and respiratory tract. Inspect the package before use to ensure intact sealing and good material condition.
2. Powder Dissolution
Use purified water or suitable buffer solution according to experimental protocols. Add solvent slowly into the container, then add the sample and stir or swirl gently until fully dissolved. For high-precision experiments, filter the solution with sterile membrane to remove impurities.
3. Dilution and Application
To prepare solutions of different concentrations, perform serial dilution with blank solvent and mix thoroughly after each step. Add proper amount of solution into reaction vessels, cell culture systems and other carriers. Conduct experiments strictly in accordance with preset parameters and keep complete records.
4. Post-operation Handling
Seal the original vial tightly immediately after use and store it as required. Clean, sterilize and store all used utensils following standard laboratory procedures.
Collect waste liquid, residues and used supplies separately. Dispose of them in compliance with waste management regulations. Random dumping is prohibited.
5. Notes
- Aqueous solution has poor stability. Prepare and use it immediately to prevent component degradation.
- The product is highly hygroscopic and light-sensitive. Use it up promptly after opening and avoid repeated opening.
- Handle gently during operation and transportation to prevent package damage, leakage and moisture absorption.
- This product is only for in vitro scientific research. Do not alter its intended use.
-
-
1. General Storage Environment
This lyophilized peptide powder is highly hygroscopic and sensitive to temperature and light. Store it in a cool, dry, dark and well-ventilated area, away from heat sources, strong light and electrical equipment. Keep it separately from corrosive and volatile chemicals to avoid cross-contamination and deterioration.
2. Storage for Unopened Products
- Short-term storage: Keep fully sealed and refrigerate at 2℃~8℃.
- Long-term storage: Seal tightly and store at -20℃ away from light.
- Keep products away from ground moisture. Do not place heavy objects on the packages to prevent damage. Follow the first-in, first-out rule. The shelf life of unopened products is 24 months under standard conditions.
3. Storage for Opened Products
Reseal the package tightly immediately after use to isolate air and moisture. Store at 2℃~8℃ in dry and dark conditions. Avoid frequent opening and use the product as soon as possible.
4. Storage for Prepared Solution
The solution is less stable than solid powder. Prepare and use it right away. For temporary storage, transfer to a clean sealed container and refrigerate at 2℃~8℃ for no more than 24 hours.
Do not store at room temperature for a long time or conduct repeated freeze-thaw cycles, which will lead to component degradation. Discontinue use and dispose of the solution properly if turbidity or precipitate appears.
5. Management of Divided Samples
Store divided samples in airtight containers with desiccant in dark places. Mark product name, subpackaging date and batch number on the container for easy management and traceability.
6. Daily Notes
Check storage facilities, packages and materials regularly. Isolate damaged, damp, caked or discolored materials in a timely manner. Use dehumidifiers in humid surroundings. Handle products gently during transportation to prevent seal damage from impact.
Hong Kong Bosen Peptide R&D Co., Limited
Hong Kong Bosen Peptide R&D Co., Limited is a professional biotechnology company headquartered in Hong Kong, with a focus on peptide research, development, production and global supply. Rooted in the Greater Bay Area’s strong biotech ecosystem, we integrate cutting-edge R&D capabilities, strict quality control systems and efficient global logistics to deliver high-quality peptide products and technical solutions to customers worldwide.
Core Business & Product Portfolio
We specialize in the R&D, customization and commercial production of high-purity peptides, modified peptides and related biotech raw materials. Our product portfolio covers:
- Therapeutic peptides: SS-31 (Elamipretide), Tirzepatide, Semaglutide, Retatrutide (RT20), etc.
- Functional peptides: GHK-Cu, TB500, KPV, NAD, Glutathione, etc.
- Custom peptide services: Custom synthesis of complex sequences, long-chain peptides (up to 200 amino acids) and cyclic peptides, as well as various modification services (N-methylation, unusual amino acid incorporation, etc.).
R&D & Manufacturing Strength
- Technical expertise: Mastery of core technologies including solid-phase peptide synthesis (SPPS), liquid-phase synthesis, advanced purification (HPLC) and strict structural characterization.
- Quality assurance: All products are produced in compliance with cGMP standards, with complete CoA, HPLC and MS reports to ensure batch-to-batch consistency and high purity (≥98%).
- Production capacity: Equipped with professional production bases in Guangzhou, supporting small-batch R&D samples to large-scale commercial production, with stable supply capacity.
Global Market & Service Philosophy
With a customer base spanning the Philippines, the United States, Brazil, Russia, Bangladesh and other regions, we adhere to the service philosophy of "Quality First, Customer Centric". We provide one-stop services including product consultation, customization, technical support and global logistics solutions (door-to-door delivery, customs clearance assistance), committed to becoming a reliable long-term partner for global biotech enterprises, research institutions and health industry clients.
Vision
We are dedicated to advancing peptide technology innovation, expanding the application of peptides in health and medical fields, and contributing to global human health with high-quality products and professional services.
ECHEMI Editorial Reference
Cibinetide, also known as ARA-290, is a synthetic 11-mer peptide that binds the tissue-protective receptor. ARA290 inhibits high glucose-induced apoptosis of NRK-52E cells. Cibinetide Protects Isolated Human Islets in a Stressful Environment and Improves Engraftment in the Perspective of Intra Portal Islet Transplantation. Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain. ARA 290 relieves pathophysiological pain by targeting TRPV1 channel: Integration between immune system and nociception.
Research & Reference Note
High Purity ARA-290 (Cibinetide) Lyophilized Powder, Research Grade Synthetic Peptide for In Vitro Lab Research is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals