Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.
Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.
| Items | Specifications |
| Item Name | GDF-8 |
| Appearance | White crystalline powder |
| Storage Condition | 2-8℃ sealed container, avoid direct light |
| Shelf Life | 2 years under standard storage environment |
| Purity | ≥99% Tested by HPLC |
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Myostatin is a kind of TGF-β family discovered as a factor involved in the modulation of the number of muscles. It inhibits the growth of skeletal muscles, and in knockout mice, an increase in skeletal muscles and a decrease in body fat mass have been reported. Myostatin activity is inhibited by follistatin, an activin-binding protein and myostatin propeptide. Growth Differentiation Factor 8 (GDF-8), also known as myostatin, is a member of the TGF-beta superfamily expressed specifically in developing and adult skeletal muscle. GDF-8 cDNA encodes a 376 amino acid (aa) prepropeptide with a 24 aa residue signal peptide, a 223 aa residue amino-terminal propeptide, and a 109 aa residue carboxy-terminal mature protein. Mature GDF-8 contains the canonical 7-cysteine motif common to other TGF-beta superfamily members.
Research & Reference Note
GDF-8 Synthetic Small Molecule Biochemical Reagent Polypeptide Raw Substance Complete HPLC Mass Spectrum Batch Inspection Documents Multiple Custom Sp is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
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