 Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Acetanilide for Sale > Acetanilide103-84-4

Acetanilide103-84-4

5 Inquiries

Unit Price:

$33-34/MT FOB

Get Latest Price 

CAS No.:

103-84-4

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-16

Contact Supplier

 Chat Now

Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

 Visit Store

Product Description
Seller Information
Inquiry History

Description

Product Detail

Acetanilide Basic information

Product Name:	Acetanilide
Synonyms:	ACETIC ACID ANILIDE;ACETYLAMINOBENZENE;ACETYLANILINE;ACETANIL;ACETANILIDE;AKOS BBS-00004291;'LGC' (4002);'LGC' (2605)
CAS:	103-84-4
MF:	C8H9NO
MW:	135.16
EINECS:	203-150-7
Product Categories:	Aromatics;Intermediates & Fine Chemicals;Pharmaceutical Intermediates;Pharmaceuticals;PENTOTHAL;Dyestuff intermediate;API;bc0001
Mol File:	103-84-4.mol

Acetanilide Chemical Properties

Melting point	113-115 °C(lit.)
Boiling point	304 °C(lit.)
bulk density	370kg/m3
density	1,121 g/cm³
vapor density	4.65 (vs air)
vapor pressure	1 mm Hg ( 114 °C)
refractive index	1.5700 (estimate)
Fp	173 °C
storage temp.	Store below +30°C.
solubility	Slightly soluble in water; very soluble in ethanol and acetone; soluble in ethyl ether.
pka	0.5(at 25℃)
form	Powder
color	Off-white to beige to grayish-blue
PH	5-7 (10g/l, H2O, 25℃)
Water Solubility	5 g/L (25 ºC)
Merck	14,50
BRN	606468
Henry's Law Constant	4.7×10² mol/(m³Pa) at 25℃, Yaws (2003)
Dielectric constant	2.9（22.0℃）
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents, caustics, alkalies.
Cosmetics Ingredients Functions	FRAGRANCE PERFUMING
InChI	1S/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)
InChIKey	FZERHIULMFGESH-UHFFFAOYSA-N
SMILES	CC(=O)Nc1ccccc1
LogP	1.160
CAS DataBase Reference	103-84-4(CAS DataBase Reference)
NIST Chemistry Reference	Acetamide, N-phenyl-(103-84-4)
EPA Substance Registry System	Acetanilide (103-84-4)

Safety Information

Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	22-26-36
WGK Germany	1
RTECS	AD7350000
Autoignition Temperature	540 °C
TSCA	TSCA listed
HS Code	29242995
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral
Hazardous Substances Data	103-84-4(Hazardous Substances Data)
Toxicity	LD50 intragastric in rats: 800 mg/kg (Smith, Hambourger)

Acetanilide Usage And Synthesis

Chemical Properties	Acetanilide, also known as Nphenylacetamide, acetanil, or acetanilide is a white to gray solid with molecular formula CH3CONHC6H5. It is an odorless colorless, glossy, crystalline powder or flakes. Acetanilide was the first aniline derivative found to possess analgesic as well as antipyretic properties and was quickly introduced into medical practice (Weast, 1981; Gnanasambandan et al., 2014). Later, it was established that in the human body it is mostly metabolized to paracetamol, this compound being responsible for the analgesic and antipyretic properties of acetanilide (Bertolini et al., 2006; Gnanasambandan et al., 2014). In addition, it was discovered that it has unacceptable toxic effects, so that acetanilide is no longer used as a drug. Acetanilide is mainly used as an intermediates in the synthesis of pharmaceuticals and dyes, as an additive for hydrogen peroxide and cellulose ester varnishes, and as a plasticizer in polymer industry as well as accelerator in the rubber industry.
Physical properties	White glossy flake crystal or white crystalline powder. Slightly soluble in cold water, soluble in hot water, methanol, ethanol, ether, chloroform, acetone, glycerol and benzene.
History	The department of internal medicine at the University of Strassburg in the 1880s was noted for its investigations into intestinal worms. Adolf Kussmaul, the director, asked two young assistants, Arnold Cahn and Paul Hepp, to treat patients with naphthalene as it had been used elsewhere as an internal antiseptic. The young doctors were disappointed with the initial results, but Hepp persevered with the naphthalene treatment in a patient suffering from a variety of complaints besides worms. Surprisingly, the fever chart revealed a pronounced antipyretic effect from this treatment. This had not been observed before, but further investigation revealed that Hepp had wrongly been supplied by Kopp’s Pharmacy in Strassburg with acetanilide instead of naphthalene! Cahn and Hepp lost no time in publishing a report on their discovery of a new antipyretic. For many years after its discovery in 1886, Acetanilide was used as an alternative to aspirin (i.e. acetyl salicylate) - an analgesic (painkiller) and antipyretic (fever reducing) drug to relieve e.g. headache, menstrual pain, and rheumatic pain. Under the name “Acetanilide” it formerly appeared in the formula of a number of patent medicines and over the counter drugs. In 1948, Julius Axelrod and Bernard Brodie discovered that Acetanilide is much more toxic in these applications than other drugs, causing methemoglobinemia and ultimately causing damage to the liver and kidneys. Thus, Acetanilide has largely been replaced by less toxic drugs, in particular acetaminophen (i.e. paracetamol), which is a metabolite of Acetanilide and whose use Axelrod and Brodie suggested in the same study.
Uses	Acetanilide is used as an intermediate in the synthesis of rubber accelerator, dyes and camphor. It is also used in the synthesis of penicillin and other pharmaceutical products. It is involved in the preparation of 4-acetamidobenzenesulfonyl chloride, which is an intermediate during the synthesis of sulfa drugs. Further, it is employed as a experimental photographic developer. In addition to this, it is used to stabilize cellulose ester varnishes.
Application	Acetanilide is used as an inhibitor of hydrogen peroxide decomposition and to stabilize cellulose ester varnishes. It is also used in the intermediation of rubber accelerator synthesis, dyes and dye intermediate synthesis, and camphor synthesis. Acetanilide is used for the production of 4-acetamidobenzenesulfonyl chloride, a key intermediate for the manufacture of the sulfa drugs. It is also a precursor in the synthesis of penicillin and other pharmaceuticals. In the 19th century acetanilide was one of a large number of compounds used as experimental photographic developers. Acetanilide is used as a EOF (electroosmotic flow) marker in the studies of affinity capillary electrophoresis for drug–protein binding. Acetanilide undergoes palladium-catalyzed cross-coupling reaction to form ortho-acylacetanilide.
Preparation	Acetanilide is prepared from aniline by acetylating it with acetic anhydride in presence of glacial acetic acid. Aniline reacts with acetic anhydride to form Acetanilide by nucleophilic substitution reaction and the reaction is called acetylation. In a 100 ml round bottom flask fitted with a reflux condensor place 5ml of aniline and 10 ml of 1:1 acetic acid and acetic anhydride mixture (5ml acetic acid and 5 ml acetic anhydride). Heat the mixture gently under reflux for 15-20 minutes on oil bath and then pour the contents while still hot with stirring into a 200ml beaker containing 100ml ice cold water. Stir the mixture vigorously to hydrolyse the excess acetic anhydride. After all the acetanilide has precipitated, collct it on buchner funnel and wash with cold water. Recrystallise the crude product from boiling water. If the product is excessively coloured add a pinch of animal charcoal to hot water and filter hot through glass wool/ cotton plug. Pure colourless crystals of acetanilide melts at 114°C (5-5.5g).
Definition	ChEBI: Acetanilide is a member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a phenyl group. It has a role as an analgesic. It is a member of acetamides and an anilide. It is functionally related to an acetic acid.
World Health Organization (WHO)	Acetanilide, a para-aminophenol derivative with analgesic, antipyretic and weak antiinflammatory activity, was introduced into medicine in 1886. It subsequently proved to be excessively myelosuppressive and has been superseded by safer alternatives.
Synthesis Reference(s)	Tetrahedron Letters, 24, p. 4533, 1983 DOI: 10.1016/S0040-4039(00)85947-X
General Description	Acetanilide is a white to gray solid. (NTP, 1992)
Air & Water Reactions	Acetanilide is sensitive to prolonged exposure to air . Water insoluble.
Reactivity Profile	Acetanilide is an amide. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Fire Hazard	Acetanilide is combustible.
Potential Exposure	This amide compound is used in rubber industry as accelerator, in plastics industry as cellulose ester stabilizer, in pharmaceutical manufacture, stabilizer for hydrogen peroxide, azo dye manufacture
Shipping	UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification Methods	Recrystallise acetanilide from water, aqueous EtOH, *benzene or toluene. [Beilstein 12 IV 373.]
Incompatibilities	Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alkyl nitrates, alkalis (liberate aniline), chloral hydrate, phenols, ferric salts
Waste Disposal	Add to flammable solvents (alcohol or benzene) and incinerate. Oxides of nitrogenmay be scrubbed from combustion gases with alkaline solution

Acetanilide Preparation Products And Raw materials

Shop Acetanilide103-84-4-Detailed Image 4

Basic Info

Product Name:

Acetanilide

Other Name:

Acetamide,N-phenyl-;Acetanilide;N-Phenylacetamide;Acetanil;Acetylaniline;Antifebrin;Benzenamine,N-acetyl-;Acetamidobenzene;Acetoanilide;N-Acetylaniline;Phenalgene;Phenalgin;N-Acetylaminobenzene;NSC 203231;NSC 7636;1-Acetylaminobenzene;Anilino methyl ketone

CAS No.:

103-84-4

Molecular Formula:

C8H9NO

InChIKeys:

InChIKey=FZERHIULMFGESH-UHFFFAOYSA-N

Molecular Weight:

135.16

Exact Mass:

135.16

BRN:

606468

EC Number:

203-150-7

UNII:

SP86R356CC

NSC Number:

757879|7636

DSSTox ID:

DTXSID2022543

Color/Form:

ORTHORHOMBIC PLATES OR SCALES FROM WATER|WHITE SHINING CRYSTALLINE SCALES|White, shining crystalline leaflets or white crystalline powder.|Colorless, glossy, crystalline material.

HScode:

29242995

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

29.1

XLogP3:

1.16

Appearance:

Off-white to beige to grayish-blue Powder

Density:

1.2190 g/cm³ @ Temp: 15 °C

Melting Point:

114.3 °C

Boiling Point:

304 °C @ Press: 760 Torr

Flash Point:

173 °C

Refractive Index:

1.5700 (estimate)

Water Solubility:

H2O: 5 g/L (25 ºC)

Storage Conditions:

Store below +30°C.

Vapor Pressure:

1 mm Hg ( 114 °C)

Vapor Density:

4.65 (vs air)

Toxicity:

Oral-Rat LD50: 800 mg/kg; Oral-Mouse LD50: 1210 mg/kg

Flammability characteristics:

Combustible in case of fire, high temperature and strong oxidant; burning and decomposition release toxic nitrogen oxide fumes

Odor:

ODORLESS

Taste:

SLIGHTLY BURNING

Dissociation Constants:

KB: 1X10-13 AT 28 °C|pKa = 0.50 at 25 °C (conjugate acid)

Collision Cross Section:

124.17 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|125 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

IT FORMS EUTECTIC MIXTURE WITH PHENOL, RESORCINOL, & THYMOL|VAPOR PRESSURE: 1 MM HG @ 114.0 °C

Air and Water Reactions:

This compound is sensitive to prolonged exposure to air (NTP, 1992). Water insoluble.

Reactive Group:

Amides and Imides

Reactivity Profile:

ACETANILIDE is an amide. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Autoignition Temperature:

1004 °F (NTP, 1992)|985 + or - 10 °F.

See More Acetanilide Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Acetanilide Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

5 Inquiries

Country	Product	Purchase Quantity	Date Posted
Russia	Acetanilide	2000 KG	Jan 21, 2025
India	Acetanilide	1.00 20' Fcl	Mar 17, 2025
Panama	Acetanilide	25 KG	Apr 11, 2025
India	ACETANILIDE	60.00 MT	Aug 7, 2023
India	Acetanilide	1.00 20' Fcl	Feb 6, 2024

Post an enquiry for this product

More Choices Find All Products for Sale 

Product Name	Grade / Content	Supplier Name	Details
ACETYLANILINE	/	Shandong zhishang chemical Co.,Ltd	Inquiry
103-84-4, hangzhou kieray	industrial Grade/98	Hangzhou KieRay Chem Co.,LTD	Inquiry
Acetanilide 99% Dideu	Industrial Grade/99	Shaanxi Dideu Medichem Co. Ltd	Inquiry
High purity Acetanilide CAS NO.103-84-4	Pharmaceutical Grade/99	Shanghai Lonwin Chemical Co.,Ltd	Inquiry
acetanilide	Industrial Grade/99	Shandong Airuike Chemical Co., Ltd.	Inquiry

Hot Related Products



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.