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tert-butyl hydroperoxide75-91-2

Name: tert-butyl hydroperoxide75-91-2
Brand: OORENT
SKU: pr2606171099
Price: 33 USD
Availability: InStock

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CAS No.:

75-91-2

Grade:

Industrial Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-17

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Qingdao Orient Chemical Co.,LTD

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Trader

Location:

China

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pharmaceutical intermediates,peptides,electronic chemicals

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Inquiry History

Description

Product Detail

tert-Butyl hydroperoxide Basic information

Product Name:	tert-Butyl hydroperoxide
Synonyms:	Butylhydroperoxid;1,1-Dimethylethyl hydroperoxide;1,1-dimethylethyl-hydroperoxid;1,1-dimethylethylhydroperoxide;trigonoxa-75(czech);trigonoxa-w70;USP -800;T-HYDRO(R)
CAS:	75-91-2
MF:	C4H10O2
MW:	90.12
EINECS:	200-915-7
Product Categories:	Organic Peroxide;Synthetic Organic Chemistry;Organics
Mol File:	75-91-2.mol

tert-Butyl hydroperoxide Chemical Properties

Melting point	-2.8 °C
Boiling point	37 °C (15 mmHg)
density	0.937 g/mL at 20 °C
vapor pressure	62 mmHg at 45 °C
refractive index	n20/D 1.403
Fp	85 °F
storage temp.	2-8°C
pka	pK1: 12.80 (25°C)
form	Liquid
color	Clear colorless
PH	4.3
Water Solubility	Miscible
Merck	14,1570
BRN	1098280
Henry's Law Constant	4.2×10⁰ mol/(m³Pa) at 25℃, Wang et al. (2017)
Exposure limits	No exposure limit is set. On the basis of its irritant properties a ceiling limit of 1.2 mg/m³ (0.3 ppm) is recommended.
Stability:	Stable, but may explode if heated under confinement. Decomposition may be accelerated by traces of metals, molecular sieve or other contaminants. Incompatible with reducing agents, combustible material, acids.
InChI	1S/C4H10O2/c1-4(2,3)6-5/h5H,1-3H3
InChIKey	CIHOLLKRGTVIJN-UHFFFAOYSA-N
SMILES	CC(C)(C)OO
LogP	1.230 (est)
CAS DataBase Reference	75-91-2(CAS DataBase Reference)
NIST Chemistry Reference	Tert-butyl hydroperoxide(75-91-2)
EPA Substance Registry System	tert-Butyl hydroperoxide (75-91-2)

Safety Information

Hazard Codes	O,C,N,T
Risk Statements	7-10-20/21/22-34-65-52/53-43-67-53-68-51/53-23-21/22
Safety Statements	14-3/7-61-45-36/37/39-24-17-16-14A-26-62-47-43
RIDADR	UN 3109 5.2
WGK Germany	3
RTECS	EQ4900000
F	3-21
Autoignition Temperature	Self-accelerating decomposition at 88 to 93 °C
TSCA	TSCA listed
HazardClass	5.2
PackingGroup	II
HS Code	29094990
Storage Class	5.2 - Organic peroxides and self-reacting hazardous materials
Hazard Classifications	Acute Tox. 2 Inhalation Acute Tox. 3 Dermal Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 Asp. Tox. 1 Eye Dam. 1 Flam. Liq. 3 Muta. 2 Org. Perox. F Skin Corr. 1C Skin Sens. 1 STOT SE 3
Hazardous Substances Data	75-91-2(Hazardous Substances Data)
Toxicity	LD50 oral (rat) 406 mg/kg LD50 skin (rabbit) 460 mg/kg LC50 inhal (rat) 500 ppm (4 h)

MSDS Information

Provider	Language
TBHP	English
SigmaAldrich	English
ACROS	English
ALFA	English

tert-Butyl hydroperoxide Usage And Synthesis

Chemical Properties	tert-Butyl hydroperoxide (TBHP) is a water-white liquid commonly commercially available as a 70% solution in water; 80% solutions are also available. It is used to initiate polymerization reactions and in organic syntheses to introduce peroxy groups into the molecule.
Uses	TBHP is an intermediate in the production of propylene oxide and t-butyl alcohol from isobutane and propylene. It is primarily used as an initiator and finishing catalyst in the solution and emulsion polymerization methods for polystyrene and polyacrylates. Other uses are for the polymerization of vinyl chloride and vinyl acetate and as an oxidation and sulfonation catalyst in bleaching and deodorizing operations. It is a strong oxidant and reacts violently with combustible and reducing materials, and metallic and sulfur compounds.
Uses	tert-Butyl hydroperoxide is used as an initiator for radical polymerization and in various oxidation process such as sharpless epoxidation. It is involved in osmium catalyzed vicinal hydroxylation of olefins under alkaline conditions. Furthermore, it is used in catalytic asymmetric oxidation of sulfides to sulfoxides using binaphthol as a chiral auxiliary and in the oxidation of dibenzothiophenes. It plays an important role for the introduction of peroxy groups in organic synthesis.
Production Methods	TBHP is produced by the liquid-phase reaction of isobutane and molecular oxygen or by mixing equimolar amounts of t-butyl alcohol and 30–50% hydrogen peroxide. TBHP can also be prepared from t-butyl alcohol and 30% hydrogen peroxide in the presence of sulfuric acid or by oxidation of tert-butylmagnesium chloride. The manufacturing process of TBHP is in a closed system.
Description	Tert-butyl hydroperoxide is an alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes. It has a role as an antibacterial agent and an oxidising agent.
Application	tert-Butyl hydroperoxide (t-BOOH) decomposes under the catalysis of metal ions to form other alkoxy and peroxy radicals, thereby generating reactive oxygen species including hydrogen peroxide. This accelerates the chain reaction of lipid peroxidation, leading to DNA damage, cytotoxicity, and alterations in intracellular calcium homeostasis, ultimately causing cellular injury and apoptosis. In scientific research, t-BOOH is frequently employed to induce pharmacological oxidative stress responses and establish an oxidative stress model in cell cultures^[3].
General Description	Watery odorless colorless liquid. Floats and mixes slowly with water.
Reactivity Profile	Most alkyl monohydroperoxides are liquid. The explosivity of the lower members (e.g., methyl hydroperoxide, or possibly, traces of the dialkyl peroxides) decreasing with increasing chain length and branching [Bretherick 2nd ed. 1979 p. 10]. Though relatively stable, explosions have been caused by distillation to dryness [Milas, JACS 1946, 68, 205] or attempted distillation at atmospheric pressure [Castrantas 1965 p. 15].
Health Hazard	tert-Butyl hydroperoxide is a strong irritant.Floyd and Stockinger (1958) observed thatdirect cutaneous application in rats did notcause immediate discomfort, but the delayedaction was severe. The symptoms were erythemaand edema within 2–3 days. Exposureto 500 mg in 24 hours produced asevere effect on rabbit skin, while a rinse of150 mg/min was severe to eyes. It is moderately toxic; the effects aresomewhat similar to those of MEK peroxide.Symptoms from oral administration in ratswere weakness, shivering, and prostration. LD₅₀ value, intraperitoneal (rats): 87 mg/kg LD₅₀ value, oral (rats): 406 mg/kg.
Flammability and Explosibility	tert-Butyl hydroperoxide is a flammable liquid and a highly reactive oxidizing agent. Pure TBHP is shock sensitive and may explode on heating. Carbon dioxide or dry chemical extinguishers should be used for fires involving tert-butyl hydroperoxide.
reaction suitability	reagent type: oxidant
Mechanism of action	The general mechanism of transition metal-catalyzed oxidative Mannich reactions of N, N-dialkyl anilines with tert-butyl hydroperoxide (TBHP) as the oxidant consists of a rate-determining single electron transfer (SET) that is uniform from 4-methoxy- to 4-cyano-N, N-dimethylanilines. The tert-butylperoxy radical is the major oxidant in the rate-determining SET step that is followed by competing backward SET and irreversible heterolytic cleavage of the carbon–hydrogen bond at the α-position to nitrogen. A second SET completes the conversion of N, N-dimethylaniline to an iminium ion that is subsequently trapped by the nucleophilic solvent or the oxidant prior to the formation of the Mannich adduct[1]. Tert-butyl hydroperoxide could induce oxidative stress in liver mitochondria at low concentrations. The damaging effect of low concentrations of tBHP in the course of pyruvate oxidation in isolated liver mitochondria is caused by the opening of the nonspecific Ca²⁺-dependent cyclosporin A-sensitive pore in the inner mitochondrial membrane[2].
Safety Profile	Moderately toxic by ingestion and inhalation. A severe skin and eye irritant. Mutation data reported. At highest dosage levels, symptoms noted were severe depression, incoordmation, and cyanosis. Death was due to respiratory arrest. Very dangerous fire hazard when exposed to heat or flame, or by spontaneous chemical reaction such as with reducing materials. Moderately explosive; may explode during distillation. Violent reaction with traces of acid. Concentrated solutions may ignite spontaneously on contact with molecular sieve. Mixtures with transition metal salts may react vigorously and release oxygen. Forms an unstable solution with 1,2-dichloroethane. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes.
Carcinogenicity	A study performed to evaluate the carcinogenicity of TBHP found it was not carcinogenic when applied to the skin of mice at 16.6% of the peroxide 6 times a week for 45 weeks. However, if its application was preceded by 0.05 mg of 4-nitroquinoline-1-oxide as a 0.25% solution in benzene applied 20 times over 7 weeks followed by TBHP (16.6% in benzene), then malignant skin tumors appeared between days 390 and 405 of the experiment . This supports the theory that peroxides are not complete carcinogens, but may act as promoters . The effects of TBHP on promotable and nonpromotable mouse epidermal cell culture lines were reported by Muehlematter et al. .
storage	tert-butyl hydroperoxide should be stored in the dark at room temperature (do not refrigerate) separately from oxidizable compounds, flammable substances, and acids. Reactions involving this substance should be carried out behind a safety shield.
Toxicity evaluation	TBHP accelerates oxidation of glutathione and decreases the metabolism of sodium hexobarbital in rat livers and is a strong oxidation agent.
Incompatibilities	tert-Butyl hydroperoxide and concentrated aqueous solutions of TBHP react violently with traces of acid and the salts of certain metals, including, in particular, manganese, iron, and cobalt. Mixing anhydrous tert-butyl hydroperoxide with organic and readily oxidized substances can cause ignition and explosion. TBHP can initiate polymerization of certain olefins.
Waste Disposal	Excess tert-butyl hydroperoxide and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.
References	[1] Maxim O, et al. Mechanistic Investigation of Oxidative Mannich Reaction with tert-Butyl Hydroperoxide. The Role of Transition Metal Salt. Journal of the American Chemical Society, 2013; 135: 1549–1557. [2] Fedotcheva N, et al. Mechanism of induction of oxidative stress in liver mitochondria by low concentrations of tert-butyl hydroperoxide. Biochemistry (Moscow), 2013; 78: 75–79. [3] MARIO ALÍA. Response of the antioxidant defense system to tert-butyl hydroperoxide and hydrogen peroxide in a human hepatoma cell line (HepG2)†[J]. Journal of Biochemical and Molecular Toxicology, 2005, 19 2: 119-128. DOI:10.1002/jbt.20061.

tert-Butyl hydroperoxide Preparation Products And Raw materials

Raw materials

Hydrogen peroxide-->tert-Butanol-->4-NITRO-2-SULFOANILINE-->Sulfuric acid hydrogen tert-butyl ester-->TERT-BUTYLMAGNESIUM CHLORIDE-->Vitamin D3-->Ascorbic Acid-->1,1-Dichloroethane-->Isobutyric acid

Preparation Products

Propylene oxide-->(+)-DISPARLURE-->1-FLUORO-4-(TRIFLUOROMETHYLTHIO)BENZENE-->2-Quinolinecarboxaldehyde-->Cinmethylin-->2-QUINOXALINECARBALDEHYDE-->5-NITRO-2-HYDROXY-4-METHOXYPYRIDINE-->2,4-DICHLORO-5-NITROPYRIDINE-->tetrahydro-2-furyl acetate-->Di-tert-butyl peroxide-->Methyl 2-bromobenzoate-->tert-Butyl peroxypivalate-->4-(METHYLSULFINYL)PHENOL-->tert-Butyl peroxyacetate-->Dimethyl Furan-2,5-dicarboxylate

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Basic Info

Product Name:

tert-Butyl hydroperoxide

Other Name:

Hydroperoxide,1,1-dimethylethyl;tert-Butyl hydroperoxide;1,1-Dimethylethyl hydroperoxide;Cadox TBH;Perbutyl H;2-Hydroperoxy-2-methylpropane;Trigonox A-W 70;Kayabutyl H;Perbutyl H 69T;t-Butyl hydroperoxide;Perbutyl H 80;tert-Butyl hydrogen peroxide;TBHP;Perbutyl H 69;Luperox TBH 70X;NSC 672;Luperox H 70;Kayabutyl H 70;T-HYDRO;Luperox TBHP;Peroxan BHP 10;Luperox TBH;H 70;2-Methylpropane-2-peroxol

CAS No.:

75-91-2

Molecular Formula:

C4H10O2

InChIKeys:

InChIKey=CIHOLLKRGTVIJN-UHFFFAOYSA-N

Molecular Weight:

90.12

Exact Mass:

90.12

BRN:

1098280

EC Number:

200-915-7

HScode:

29094990

Categories:

Alcohols, Phenols, Phenol Alcohols

Characteristics

PSA:

29.5

XLogP3:

-1.3 (calculated)

Appearance:

Clear colorless Liquid

Density:

0.8960 g/cm³ @ Temp: 20 °C

Melting Point:

-8 °C

Boiling Point:

35 °C @ Press: 20 Torr

Flash Point:

85 °F

Refractive Index:

1.399

Water Solubility:

Solubility in water: miscible

Storage Conditions:

2-8°C

Vapor Pressure:

Vapour pressure, kPa at 20°C: 3.07 (calculated)

Vapor Density:

Relative vapour density (air = 1): 3.1

Toxicity:

Oral-Rat LD50: 406 mg/kg; Oral-Mouse LD50: 710 mg/kg

Flammability characteristics:

In case of heat, open flame, reducing agent is flammable; burning produces irritating smoke

Explosive limit:

vol% in air: 50

See More tert-Butyl hydroperoxide Properties 

Hazard Identification

Classification of the substance or mixture

Germ cell mutagenicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H341 Suspected of causing genetic defects
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames, NO sparks and NO smoking. NO contact with flammables. Above 43Â°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Fireproof. Separated from combustible substances and reducing agents. Cool. Inspect container frequently to identify bulging and leaking.

See More tert-Butyl hydroperoxide Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

25 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	tert-butyl hydroperoxide	50.00 KG	May 27, 2025
India	tert-butyl hydroperoxide	10.00 MT	Jan 19, 2024
Kuwait	TERT BUTYL HYDROPEROXIDE	1.00 KG	Mar 24, 2025
Pakistan	tert-butyl hydroperoxide	200.00 L	Jan 14, 2025
India	tert-Butyl hydroperoxide	1.00 MT	Jul 22, 2024
Russia	TBHP	20 MT	May 3, 2024
Sri Lanka	Tera Butyl Hydroperoxide	30.00 KG	Feb 18, 2024
India	tert-Butyl hydroperoxide	500.00 KG	Mar 3, 2026
United States	Tert-butyl hydroperoxide	10 MT	Jan 14, 2026
United Arab Emirates	Tert-butyl hydroperoxide	3.81 MT	Dec 4, 2025
United Arab Emirates	(TBHP) Tert-butyl Hydroperoxide	10.00 KG	Sep 16, 2025
Sri Lanka	tert butyl hydroxyperoxide	1.00 MT	Nov 8, 2024
Saudi Arabia	TBHP	1 40' Fcl	Aug 12, 2024
Kuwait	Tert-butyl Hydroperoxide (TBHP)	50.00 KG	Aug 5, 2025
Vietnam	Tert-butyl hydroperoxide	20 TON	May 22, 2025
United Arab Emirates	tert-butyl hydroperoxide	1.00 20' Fcl	Mar 4, 2025
Germany	tert-Butyl hydroperoxide solution sol. 70% (75-91-2)	40 MT	Nov 19, 2024
United Kingdom	Trigonox	25 MT	Jun 28, 2024
Pakistan	Tert-Butyl Hydroperoxide	5 MT	Feb 14, 2024
South Africa	TBHP 85% Colorless Transparent Liquid Do Sender	100 KG	Jul 28, 2023

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tert-butyl hydroperoxide75-91-2

Product Description

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