1. Product Overview
Alprostadil, also known as Prostaglandin E1 (PGE1), is a high-purity synthetic bioactive prostaglandin molecule with pharmaceutical-grade specifications. Though not a traditional amino-acid peptide, it exhibits peptide-like high biological activity and precise signaling regulation, widely classified as a specialty therapeutic biomolecule. Produced via standardized synthetic processes with ≥99% HPLC purity, this stable small-molecule compound features ultra-high biological availability, consistent batch repeatability and low systemic irritation. As a potent EP receptor agonist, Alprostadil specializes in vascular dilation, microcirculation activation, smooth muscle relaxation and anti-platelet aggregation. It is extensively applied in vascular function research, peripheral circulation repair, microvascular lesion conditioning and high-end pharmaceutical raw material formulation development.
2. Basic Specifications
- Product Name: Alprostadil Pharmaceutical Grade
- Full Name: Prostaglandin E1 (PGE1)
- CAS Number: 745-65-3
- Molecular Weight: 354.48 Da
- Purity: ≥99.0% (HPLC)
- Appearance: White sterile lyophilized powder
- Solubility: Soluble in sterile water and aqueous solvent
- Core Feature: Potent microcirculation activator & vascular smooth muscle regulator
- Grade Standard: Pharmaceutical raw material grade, low endotoxin, heavy metal compliant
- Storage: -20°C sealed, dry and protected from light
- Shelf Life: 24 months under standard storage conditions
3. Mechanism of Action
Alprostadil exerts targeted vascular and tissue regulation by selectively binding to EP prostanoid receptors distributed on vascular smooth muscle, endothelial cells and peripheral tissues. It activates intracellular adenylate cyclase, elevates cAMP levels and reduces intracellular calcium concentration, triggering continuous vascular smooth muscle relaxation and systemic microvascular dilation. Meanwhile, it effectively inhibits platelet adhesion and aggregation, improves blood rheology, and eliminates microcirculation stasis and hypoxic damage.
Different from common vasodilators with transient efficacy, Alprostadil delivers dual vascular protection and metabolic optimization. It repairs damaged vascular endothelial function, improves peripheral tissue oxygen and nutrient supply, blocks inflammatory cascades caused by microcirculation disorders, and achieves long-term stabilization of vascular physiological function without endocrine disturbance or drug resistance.
4. Core Benefits & Applications
- Microcirculation Activation: Dilates peripheral microvessels, improves blood flow velocity, relieves tissue ischemia and hypoxia, and repairs microcirculation dysfunction caused by aging and vascular sub-health.
- Vascular Endothelial Repair: Protects vascular endothelial cells, reduces endothelial inflammatory damage, improves vascular elasticity, and delays peripheral vascular tissue degeneration.
- Anti-Thrombotic & Blood Regulation: Inhibits abnormal platelet aggregation, optimizes blood rheological properties, and reduces the risk of microvascular stasis and occlusion.
- Smooth Muscle Regulation: Relaxes cavernosal and peripheral smooth muscle, improves local blood perfusion, and supports physiological tissue function recovery.
- Professional Research Use: High-purity API for vascular pharmacology, microcirculation mechanism research, endothelial repair study and pharmaceutical formulation development.
5. Advantages of 99% Pharmaceutical-Grade Alprostadil
- Precise EP receptor targeting: Specific binding to prostanoid receptors, accurate vascular regulation with minimal systemic side effects
- Dual dilation & repair efficacy: Combines rapid microcirculation activation and long-term endothelial repair, superior to single-effect vasodilators
- Small-molecule high permeability: Ultra-low molecular weight ensures fast tissue penetration and high bioavailability
- ≥99% HPLC ultra-high purity, strict single impurity control, zero batch difference for synthetic prostaglandin biomolecule
- Low endotoxin and ultra-low heavy metals, fully compliant with pharmaceutical raw material standards, stable activity and formulation compatibility
6. Safety & Usage Features
Alprostadil is a high-safety pharmaceutical biomolecule with reliable biological tolerance. It features mild physiological vascular regulation, no hormone interference, no cumulative toxicity and no drug dependence. Standard cyclic use safely optimizes microcirculation, repairs endothelial damage and improves tissue hypoxia status, suitable for long-term vascular sub-health conditioning and high-standard biomedical research applications.
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Quality is our core competitive advantage. We strictly follow standardized production and quality control systems, with all peptide products including Vesugen polypeptide tested by high-precision HPLC to ensure a purity of 98%-99%. Equipped with independent sterile laboratories and advanced testing equipment, we conduct full-process monitoring from raw material screening, synthesis, purification to lyophilization. Every batch of products comes with complete test reports, guaranteeing high stability, high activity and zero impurities, fully meeting international research and commercial application standards.
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