Clanobutin

CAS No.: 30544-61-7

Product Overview

Clanobutin is a synthetic aromatic carboxylic acid derivative belonging to the benzamide-related compounds. Its molecular structure incorporates a chlorobenzoyl group, a methoxy-substituted phenyl ring, and a butyric acid side chain, providing favorable lipophilic and physicochemical properties for pharmaceutical research.

Historically, Clanobutin has been investigated as a choleretic (bile secretion-promoting) and digestive function-modulating agent, with studies also indicating effects on hepatic gluconeogenesis and lipid metabolism. Although it is not a widely marketed therapeutic agent today, it continues to attract interest as a research compound in studies of liver function, metabolic regulation, gastrointestinal pharmacology, and medicinal chemistry. (medkoo.com)

Key Features

• Aromatic benzamide derivative with a well-defined chemical structure

• Contains both hydrophobic aromatic groups and a polar carboxylic acid functionality

• Suitable as a pharmaceutical research reference compound

• Useful for metabolism and hepatobiliary research

• Stable solid with good compatibility for laboratory investigations

• Valuable intermediate for structure–activity relationship (SAR) studies

Potential Research Applications

Hepatic Metabolism Research

Experimental studies have shown that Clanobutin can influence hepatic gluconeogenesis, making it a useful tool for investigating:

• Glucose metabolism

• Hepatic energy regulation

• Carbon metabolism pathways

• Liver biochemical function

Hepatobiliary Studies

Clanobutin has historically been evaluated for its potential choleretic activity, supporting research involving:

• Bile secretion

• Liver physiology

• Hepatobiliary function

• Digestive system pharmacology

Gastrointestinal Pharmacology

The compound has also been explored for its effects on digestive function and inflammatory bowel conditions in experimental settings, making it of interest in gastrointestinal pharmacology research. (biosynth.com)

Medicinal Chemistry

Its unique scaffold offers opportunities for:

• Lead compound optimization

• Drug discovery programs

• Analogue synthesis

• Structure–activity relationship (SAR) studies

• Pharmacological mechanism investigations

Functional Characteristics

The molecular architecture combines several functional elements:

• Chlorobenzoyl group enhances hydrophobic interactions and molecular stability.

• Methoxy-substituted aromatic ring contributes to electronic modulation and receptor interaction potential.

• Carboxylic acid functionality provides opportunities for salt formation and synthetic modification.

• Flexible butyric acid linker offers structural adaptability for medicinal chemistry applications.

This combination makes Clanobutin an attractive scaffold for pharmaceutical and biochemical research.

Advantages

• Well-characterized research compound

• Useful model molecule for hepatic metabolism studies

• Suitable reference standard for analytical applications

• Applicable in pharmaceutical R&D programs

• Potential starting material for novel derivative development

• Compatible with a variety of analytical techniques including HPLC and LC-MS

Typical Applications

• Pharmaceutical research

• Drug discovery

• Medicinal chemistry

• Liver metabolism studies

• Gastrointestinal pharmacology

• Analytical reference standards

• Biochemical mechanism research

• Academic and industrial laboratory investigations

Storage

Store in a tightly sealed container in a cool, dry, well-ventilated environment. Protect from excessive moisture, direct sunlight, and strong oxidizing agents. Long-term storage under refrigerated or frozen conditions is recommended for research-grade material to maintain stability. (ChemicalBook)

Industry Outlook

Although Clanobutin is no longer considered a mainstream pharmaceutical ingredient, it retains value as a specialty research chemical. Increasing interest in metabolic disorders, liver disease mechanisms, and small-molecule drug discovery continues to support demand for well-characterized compounds that serve as pharmacological probes and reference materials. Its defined biological profile and versatile chemical structure make it a useful resource for both academic institutions and pharmaceutical research organizations.

Disclaimer: The application descriptions above are based on published scientific literature, historical pharmacological investigations, and the known chemical characteristics of Clanobutin. They are intended solely for research and product information purposes and should not be interpreted as claims of clinical efficacy or approved therapeutic use.