 Home > Specialty Chemicals > Rehmannioside D for Sale > RehmanniosideD

RehmanniosideD

Unit Price:

$2000-2100/G EXW

Get Latest Price 

CAS No.:

81720-08-3

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Packaging:

5mg

Price valid (until):

2026-07-23

Contact Supplier

 Chat Now

Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

 Visit Store

Product Description
Seller Information

Description

Rehmannioside D (RD) is a major bioactive iridoid glycoside isolated from the roots of Rehmannia glutinosa (known as Di Huang or Chinese Foxglove), a foundational herb in traditional medicine. Pharmacological and biochemical research indicates that Rehmannioside D acts as a potent anti-inflammatory, tissue-protective, and anti-osteoporotic agent.

Its primary functions and newly discovered molecular mechanisms include:

Primary Biological and Pharmacological Functions

Anti-Osteoporotic and Bone Protection: Modern clinical pharmacology shows that Rehmannioside D prevents estrogen-deficiency-induced bone loss. It protects bone microarchitecture through a dual mechanism:
1. It suppresses the canonical MAPK and NF-κB signaling pathways to stop bone-resorbing cells (osteoclasts) from differentiating.
2. It binds directly to the c-Jun protein, dismantling the AP-1 complex to induce programmed cell death (apoptosis) in mature, overactive osteoclasts.
Hepatoprotection (Anti-Fibrotic Action): Rehmannioside D serves as an active Sirt7 modulator to treat liver injury. It upregulates Sirt7 expression, downregulates the acetylated p53 pathway, and blocks hepatocyte apoptosis, effectively reducing liver fibrosis and structural collagen deposition.
Ovarian and Fertility Support: Within traditional herbal formulas (such as the Zuogui Pill or Kuntai capsule), Rehmannioside D acts as a core active ingredient to combat Diminished Ovarian Reserve (DOR). It works via the FOXO1/KLOTHO axis to reduce elevated follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels while promoting endometrial repair.
Neuroprotection Against Stress: In neural model testing (such as PC-12 cells), it shields brain tissues from corticosterone-induced stress and damage. It suppresses mitochondrial apoptosis pathways by downregulating the toxic Bax/Bcl2 ratio and minimizing Cleaved-caspase 3 expression.
Anti-Angiogenic Properties: Research indicates that Rehmannioside D restrains the migration of human umbilical vein endothelial cells (HUVECs), indicating that it can regulate abnormal blood vessel growth.

Basic Info

Product Name:

Rehmannioside D

Other Name:

β-D-Glucopyranoside,(1S,4aS,5R,7aR)-1-(β-D-glucopyranosyloxy)-5,7a-dihydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-4a(1H)-yl 2-O-β-D-glucopyranosyl-;β-D-Glucopyranoside,1-(β-D-glucopyranosyloxy)-5,7a-dihydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-4a(1H)-yl 2-O-β-D-glucopyranosyl-,[1S-(1α,4aα,5α,7aα)]-;(1S,4aS,5R,7aR)-1-(β-D-Glucopyranosyloxy)-5,7a-dihydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-4a(1H)-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside;Rehmannioside D

CAS No.:

81720-08-3

Molecular Formula:

C27H42O20

InChIKeys:

InChIKey=JQEFRKPLHFKTFL-SNQOEBIKSA-N

Molecular Weight:

686.610

Exact Mass:

686.61

Categories:

Characteristics

PSA:

327.60000

XLogP3:

-5.78

Density:

1.8±0.1 g/cm3

Boiling Point:

1052.4±65.0 °C at 760 mmHg

Flash Point:

590.3±34.3 °C

Refractive Index:

1.707

See More Rehmannioside D Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Rehmannioside D Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

Post an enquiry for this product

More Choices Find All Products for Sale 

Product Name	Grade / Content	Price	Supplier Name	Details
Rehmannioside D	/99.00		HANGZHOU LEAP CHEM CO., LTD.	Inquiry
Rehmannioside D 99% see COA kanbei	Industrial Grade/99		Henan Lihao Chem Plant Limited	Inquiry
Rehmannioside D	Pharmaceutical grade/99	$10/G EXW	Wuhan Pnq Int Trade Co., Ltd	Inquiry