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Lanatoside C

Unit Price:

$600-700/G FOB

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CAS No.:

17575-22-3

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Packaging:

20mg

Price valid (until):

2026-07-22

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information

Description

Lanatoside C (also known as isolanid) is a natural cardiac glycoside isolated from the leaves of the plant Digitalis lanata (woolly foxglove). It belongs to the same pharmacological family as digoxin and digitoxin. Clinically, it is used to manage congestive heart failure and supraventricular cardiac arrhythmias (such as atrial fibrillation), though recent biomedical research also highlights its powerful anticancer, antiviral, and anti-aging (senolytic) properties.

The primary biological functions and mechanisms of Lanatoside C include:

1. Cardiovascular Regulation (Primary Clinical Function)

Lanatoside C regulates cardiac performance through direct cellular pump inhibition and autonomic nervous system modulation:

Positive Inotropic Effect (Increased Force): It binds to and inhibits the extracellular face of the Na⁺/K⁺-ATPase pump on cardiac muscle cell membranes. This halts the extrusion of sodium (Na⁺), causing intracellular sodium accumulation. High internal sodium shifts the concentration gradient, slowing down the Na⁺/Ca²⁺ exchanger (NCX). As a result, calcium (Ca²⁺) accumulates in the cell, binding to troponin C and triggering a much stronger, more efficient myocardial contraction.
- Negative Chronotropic & Dromotropic Effects (Decreased Rate): It enhances vagal (parasympathetic) nerve tone. This slows down the firing of the sinoatrial (SA) node to lower the heart rate and prolongs the electrical refractory period in the atrioventricular (AV) node to control erratic rapid heartbeats in atrial fibrillation.
2. Tumor Suppression & Immunotherapy Sensitization

Beyond its classic cardiac uses, Lanatoside C acts via multiple molecular channels to destroy malignant cells:
- Treg Inhibition: It serves as a potent inhibitor of regulatory T cells (Tregs), which tumors use to hide from the immune system. It binds to the E3 ligase STUB1, forcing the degradation of RUNX1 (a component vital for FOXP3 expression), thereby boosting anti-tumor immunity and synergizing with anti-PD-1 treatments.
- - Immunogenic Cell Death (ICD): It efficiently induces hallmarks of ICD, causing dying cancer cells to release signals like calreticulin and ATP that prime the host immune system to attack the tumor.
  3. Senolytic Activity (Anti-Aging Research)
  
  Lanatoside C has been identified as a highly targeted senolytic compound. It alters cell membrane potentials and acidifies senescent (worn out, non-dividing) endothelial cells, cleanly driving them into caspase-dependent apoptosis. In animal models, this function significantly reduces overall senescence burden and helps shrink atherosclerotic plaques.

Basic Info

Product Name:

Lanatoside C

Other Name:

Card-20(22)-enolide,3-[(O-β-D-glucopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-,(3β,5β,12β)-;Lanatoside C;(3β,5β,12β)-3-[(O-β-D-Glucopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide;Cedilanid;Digilanide C;Isolanid;Isolanide;Ceglunate;Celadigal;Lanimerck;Cetosanol;Allocor;Ceglunat;Celanid;Celanide;Lanatigen C;Digilanogen C;NSC 119991;NSC 7533;Digilanid C;35-86-9;11019-78-6;37267-71-3

CAS No.:

17575-22-3

Molecular Formula:

C49H76O20

InChIKeys:

InChIKey=JAYAGJDXJIDEKI-PTGWOZRBSA-N

Molecular Weight:

985.12

Exact Mass:

985.12

EC Number:

241-546-1

NSC Number:

119991|7533

DSSTox ID:

DTXSID7023198

Categories:

Saccharides

Characteristics

PSA:

288.28000

XLogP3:

0.61310

Density:

1.42±0.1 g/cm3 (20 ºC 760 Torr)

Melting Point:

272-274°C

Boiling Point:

741.7°C (rough estimate)

Refractive Index:

1.7630 (estimate)

Storage Conditions:

−20°C

Specific rotation:

D20 +33.4 to +33.7° (200 mg dry weight in 10 ml alcohol)

See More Lanatoside C Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Acute toxicity - Category 3, Inhalation

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H311 Toxic in contact with skin H331 Toxic if inhaled
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P316 Get emergency medical help immediately. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Lanatoside C Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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Lanatoside C

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

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