Wholesale High Quality Ara-290 Peptide 5mg 10mg Vials CAS 1208243-50-8

ARA-290 is a synthetic 11-amino acid peptide derived from the erythropoietin (EPO) hormone, specifically engineered to target the innate repair receptor (IRR)—a unique receptor subtype that mediates tissue-protective and anti-inflammatory responses without stimulating red blood cell production. Unlike traditional EPO, ARA-290 lacks erythropoietic activity, minimizing risks such as polycythemia (elevated red blood cell count) while retaining its neuroprotective, analgesic, and regenerative properties.

Mechanism of Action

ARA-290 binds selectively to the IRR, a heterodimer of the EPO receptor (EPOR) and the β-common receptor (βcR). This interaction activates intracellular signaling pathways, including JAK2/STAT3, PI3K/Akt, and MAPK, which collectively promote:

• Anti-inflammatory effects: Suppression of pro-inflammatory cytokines (e.g., TNF-α, IL-6) and enhancement of anti-inflammatory mediators (e.g., IL-10).
• Neuroprotection: Reduction of neuronal apoptosis, oxidative stress, and mitochondrial dysfunction in conditions like neuropathic pain and ischemic injury.
• Tissue regeneration: Stimulation of angiogenesis (new blood vessel formation), wound healing, and cellular repair mechanisms.
• Analgesia: Modulation of pain signaling pathways, particularly in chronic neuropathic pain syndromes.

Key Clinical Applications & Benefits

1. 1. Neuropathic Pain Management
   • ARA-290 has demonstrated efficacy in reducing pain intensity and improving quality of life in patients with small fiber neuropathy (SFN), a condition often resistant to conventional analgesics.
   • Clinical trials show significant reductions in allodynia (pain from non-painful stimuli) and hyperalgesia (exaggerated pain response) with minimal side effects.
2. 2. Diabetic Complications
   • In diabetic patients, ARA-290 may protect against diabetic neuropathy by preserving nerve function and reducing inflammation.
   • Early studies suggest potential benefits for diabetic retinopathy and cardiovascular complications via its anti-inflammatory and vasoprotective effects.
3. 3. Wound Healing & Tissue Repair
   • ARA-290 accelerates wound closure in chronic ulcers (e.g., diabetic foot ulcers) by promoting angiogenesis and reducing chronic inflammation.
   • Preclinical models indicate efficacy in ischemic tissue repair, such as myocardial infarction and stroke recovery.
4. 4. Inflammatory & Autoimmune Disorders
   • Its ability to downregulate inflammatory cytokines makes ARA-290 a candidate for conditions like rheumatoid arthritis, Crohn’s disease, and multiple sclerosis, though clinical data remain preliminary.
5. 5. Cardioprotection
   • ARA-290 may mitigate ischemia-reperfusion injury (e.g., after heart attacks) by reducing oxidative stress and apoptosis in cardiac tissue.

Safety & Tolerability

• Phase I/II trials report ARA-290 as well-tolerated, with no serious adverse events linked to erythropoiesis (e.g., blood clots, hypertension).
• Its short half-life (~2–3 hours) necessitates frequent dosing in some regimens, though newer formulations aim to extend duration.

Regulatory Status & Research Landscape

• ARA-290 is currently in Phase II/III clinical development for neuropathic pain and diabetic complications, with ongoing studies exploring its broader therapeutic potential.
• The U.S. FDA has granted Orphan Drug Designation for SFN, highlighting its unmet medical need.
• Research continues to optimize delivery methods (e.g., oral formulations, sustained-release implants) and identify biomarkers for patient stratification.

Packing: 

  1. Weight <1kg ---- Fluorinated bottle 

  2. 25kg ---- Plastic bucket

  3. 180- 200kg ---- Drum

 P.S.: we accept packaging customization.

Delivery:  

1. We have large quantity raw powder in stock, normally could ship out within 3 working days. 

2. For rush delivery, please contact our sales team for particular arrangement.

Shipping:

1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.

2. Shipping details & shipping documents will be provided and sent to customers as long as it is ready.

3. We keep tracking the shippment until clients well received.

4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.

5. 

Natrue is a high-end brand company focusing on the biomedical industry and integrating R&D, production and sales. It has an independent R&D center, advanced laboratory equipment and a professional R&D team, a GMP standard production workshop, a complete set of internationally advanced assembly line equipment, a preparation workshop with a cleanliness level of 100,000, as well as sophisticated testing instruments and scientific testing methods, providing solid technical support for the production of high-quality products. Through long-term R&D, production, and sales practices, it has formed its own unique product line, providing users with products of reliable quality at highly affordable prices. We strictly control quality, ensure the stability of product quality in all aspects, and win the trust of customers with high quality and high-level development.

Our team of experienced professionals is committed to delivering innovative solutions and exceptional customer service. We work closely with our clients to understand their unique needs and develop customized products to meet their specific requirements. With a state-of-the-art manufacturing facility and strict quality control measures, we ensure that our products meet the highest standards of safety and purity.