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What is Semaglutide ?

  Semaglutide acts similar to a human glucagon peptide-1 (GLP-1) that works similar to a hormone produced in our body called incretin. Incretin stimulates insulin secretion and sugar metabolism in response to increased glucose levels which usually occurs after meals. Patients with type 2 diabetes are usually at a total loss with incretin production.
The Semaglutide, initially only used as diabetes medication , is the first drug since(2014) approved to treat chronic weight management in the 70% of adults who are obese or overweight. Research continues to show the effectiveness of semaglutide for weight loss， It also highlights the value of treating obesity as a chronic metabolic disease instead of expecting people to rely solely on willpower and lifestyle changes to manage their condition.It achieves potent weight loss and glycemic contro l by suppressing appetite, increasing energy expenditure and improving metabolism , while also improving metabolic disorders such as blood lipids and fatty liver.

• Items	Specifications
  Product Name	Semaglutide
  Form	Solid freeze-dried powder
  Storage condition	-20°C
  Purity	99%
  Packaging	Bottle, Can, Drum, Plastic Container, Vacuum Packet (According to customers' requirements)
  Trademark	Customzied accepted

1. Core target: mimic endogenous GLP‑1
   GLP‑1 (glucagon-like peptide‑1) is secreted by intestinal tract after meals. Structural modification of semaglutide extends its half-life, rendering it resistant to degradation by human enzymes and enabling sustained activation of GLP‑1 receptors across multiple organs.

2. Glucose-lowering mechanism 
   Glucose-dependent insulin secretion: stimulates pancreatic β-cells to secrete insulin only when blood glucose rises; no effect under normal glycemia, leading to minimal hypoglycemia risk.
   Suppress glucagon secretion: inhibits release of hyperglycemic glucagon to further control blood sugar.
   Delay gastric emptying: slow gastrointestinal digestion and flatten postprandial blood glucose spikes.
   Improve insulin resistance: enhance insulin sensitivity of peripheral muscle and adipose tissues.

3. Weight-loss mechanism 
   Acts on hypothalamic appetite center in the brain to curb appetite and cravings for high-calorie food, spontaneously lowering total food intake.
   Prolong satiety via delayed gastric emptying, extending the feeling of fullness.
   Regulate energy metabolism: slightly boost energy expenditure and reduce visceral fat accumulation.

4. Cardiorenal protective mechanism 
   Alleviate vascular burden by weight loss, lipid regulation and blood pressure reduction.
   Directly act on myocardium and vascular endothelium to exert anti-inflammatory and anti-oxidative effects, lowering cardiovascular event risks.
   Optimize renal blood flow and glomerular filtration, reduce urinary protein excretion to protect kidney function.

    Hong Kong City Trade Co., Ltd. was established in 2019 and possesses strong R&D capabilities, excellent synthesis technology, and advanced quality control measures. We effectively collaborate with major companies and manufacturers, and serve society and a wide range of users based on the principles of industrial development. We consistently focus on market demand, continuously synthesizing new chemical products and pharmaceutical intermediates with high technological content, primarily exporting to the United States, India, South Africa, Nigeria, and many other countries and regions. We have extensive export experience to ensure safe transportation and guarantee that every customer receives their goods safely and promptly.