3',5'-Di-O-benzyl Entecavir Entecavir Intermediate CAS 142217-81-0 Entecavir Impurity 4 NT

3',5'-Di-O-benzyl Entecavir (CAS 142217-81-0) is a key protected intermediate in the synthesis of Entecavir, a potent reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus (HBV) infection. This compound is also known as Entecavir Intermediate N8, Entecavir Impurity 5, or 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one .

Role in Pharmaceutical Synthesis:

• Key Intermediate: This compound serves as a critical protected intermediate in the synthetic pathway of Entecavir. The benzyloxy (Bn) protecting groups at the 3' and 5' positions are later removed to yield the final active pharmaceutical ingredient .

• Impurity Reference Standard: As Entecavir Impurity 5, this compound is used as a reference standard for analytical method development, method validation (AMV), and quality control (QC) applications in Entecavir API and formulation manufacturing .

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Chemical Characteristics:

• Features a complex chiral cyclopentyl core with two benzyloxy protecting groups

• Contains a guanine base (purine-6-one structure) with an amino group at the 2-position

• The benzyl groups provide protection during the multi-step synthesis of Entecavir

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Applications:

• Pharmaceutical Manufacturing: As a key intermediate in the commercial synthesis of Entecavir API

• Analytical R&D: Serves as a reference standard for impurity profiling and quality control in Entecavir production

• Regulatory Submissions: Used in ANDA and DMF filings for Entecavir-related drug products

• Antiviral Research: Suitable for studies on HBV polymerase inhibition and nucleoside analogue development

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Packaging: ___ (e.g.: 1g, 5g, 10g per package, as per customer's request)

Storage: Store in a cool, dry, well-ventilated area, away from direct sunlight and moisture. Recommended storage temperature: 4°C, protect from light . For long-term storage, -20°C is recommended

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