miramistin15809-19-5

2. Synthetic Raw Materials for Miramistin API

• Myristic acid
• 3-Aminopropyldimethylamine
• Benzyl chloride
• Hydrochloric acid
• Purified water

3. Excipients for Formulated Preparations

0.01% Topical Spray Solution

• Purified water (solvent)

0.5% Miramistin Ointment

• Disodium edetate
• Poloxamer 338
• Macrogol 400, Macrogol 1500

4. Finished Miramistin Preparations

1. 0.01% Topical disinfectant spray
   
   
   Available sizes: 50ml, 150ml, 500ml; equipped with special nozzles for gynecological & urological use
2. 0.5% Miramistin ointment
   
   
   For skin wounds and fungal infections
3. Vaginal suppositories
4. Miramistin API powder (for compounding by pharmaceutical manufacturers)

1. Product Function

   It destroys bacterial cell membranes via cationic adsorption, effective against bacteria, fungi and partial viruses, widely used in external disinfection pharmaceuticals in Russia and Eastern Europe

   Short Business Version (for email/COA header)

   Product Name: Miramistin

   
   

   CAS Number: 15809-19-5

   
   

   Chemical Name: Benzyldimethyl[3-(myristoylamino)propyl]ammonium chloride

   
   

   Grade: Pharmaceutical API / Research Grade

   
   

   Purity: ≥98% HPLC

   
   

   Appearance: White to light yellow solid

   • Molecular Weight: 439.12 g/mol
   • EINECS No.: 239-908-9
   • Appearance: White to pale yellow crystalline solid
   • Melting Point: 54 °C
   • Storage Condition: 2–8°C, sealed and away from light

   • Full Chemical Nomenclature

     1. IUPAC Name: N-Benzyl-N,N-dimethyl-3-tetradecanamidopropan-1-aminium chloride
     2. Standard Chemical Name: Benzyldimethyl[3-(myristoylamino)propyl]ammonium chloride
     3. Common Synonyms: Miramistin, Myramistin, Miramystin, Dt 2 (surfactant)
     4. Russian Commercial Name: Мирамистин

     5. Molecular Parameters

        • Linear Formula: \(\boldsymbol{C_{26}H_{47}ClN_{2}O}\)
        • Molecular Weight: 439.12 g/mol
        • Exact Mass: 438.3377
        • Elemental Composition (Wt%):
          
          
          C:71.12%, H:10.79%, Cl:8.07%, N:6.38%, O:3.64%

        •  Physical & Chemical Properties

          1. Appearance: White to pale yellow crystalline solid, hygroscopic
          2. Melting Point: 54 °C
          3. Solubility:
             • Soluble in methanol, ethanol, chloroform, isopropanol
             • Slightly soluble in purified water; forms clear low-concentration aqueous solution
             • Insoluble in alkanes, ether
          4. Stability: Stable under sealed, cool & dark environment; decomposes under strong UV light / high temperature (>80℃)
          5. Amphiphilic Character: Cationic quaternary ammonium surfactant, dual hydrophilic & lipophilic structure
          6. pH of 0.01% Aqueous Solution: 5.0–7.0 (mild neutral, low irritation for human mucosa)
          7. Odor: Almost odorless, faint mild amine odor for high-purity grade

          8. 2 Brief Synthesis Flow

             1. Amidation: Myristic acid reacts with 3-Aminopropyldimethylamine to generate myristamidopropyl dimethylamine intermediate
             2. Quaternization: Intermediate reacts with benzyl chloride under heating to form crude quaternary ammonium salt
             3. Acidification: Adjust pH with HCl to obtain anhydrous Miramistin chloride
             4. Purification: Recrystallization with ethanol-water system
             5. Drying: Vacuum low-temperature drying to remove residual solvent, get pure solid API

             6. Grades Available

                1. Pharmaceutical API Grade (for human topical drug formulation)
                2. Research Reference Standard (≥99.5%, lab testing, HPLC calibration)
                3. Cosmetic Grade (disinfectant raw material for skincare)

                4.  Mode of Action

                   Cationic ammonium group carries positive charge, binds electrostatically to negatively charged phospholipid layers of bacterial/fungal cell membranes:
                   1. Destroys membrane permeability barrier
                   2. Leaks intracellular protein, nucleic acid & electrolytes
                   3. Blocks microbial metabolism, leads to irreversible cell death
                      
                      
                      Advantage: Low risk of inducing drug resistance compared with antibiotics

                   4. 2 Target Microorganisms

                      • Gram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes
                      • Gram-negative bacteria: E. coli, Pseudomonas aeruginosa, Neisseria gonorrhoeae
                      • Fungi & yeasts: Candida albicans, Trichophyton (dermatophytes)
                      • Partial enveloped viruses: Herpes simplex, influenza virus