Permium in stock TR different peptide tirzepatide peptide 100mg

What is Tirzepatide ?

  Tirzepatide (LY3298176) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is being developed for the treatment of type 2 diabetes. Tirzepatide (LY3298176) shows significantly better efficacy with regard to glucose control and weight loss than do Dulaglutide. Tirzepatide, also known as LY 3298176, is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide has a greater affinity to GIP receptors than to GLP-1 receptors, and this dual agonist behavior has been shown to produce greater reductions of hyperglycemia compared to a selective GLP-1 receptor agonist. Signaling studies reported that tirzepatide mimics the actions of natural GIP at the GIP receptor. Tirzepatide was approved for improving blood sugar control in adults with type 2 diabetes, as an addition to diet and exercise.

• Items	Specifications
  Product Name	Tirzepatide
  Form	Solid freeze-dried powder
  Storage condition	-20°C
  Purity	99%
  Packaging	Bottle, Can, Drum, Plastic Container, Vacuum Packet (According to customers' requirements)
  Trademark	Customzied accepted

  

1. Core target: mimic endogenous GLP‑1
   GLP‑1 (glucagon-like peptide‑1) is secreted by intestinal tract after meals. Structural modification of semaglutide extends its half-life, rendering it resistant to degradation by human enzymes and enabling sustained activation of GLP‑1 receptors across multiple organs.

2. Glucose-lowering mechanism 
   Glucose-dependent insulin secretion: stimulates pancreatic β-cells to secrete insulin only when blood glucose rises; no effect under normal glycemia, leading to minimal hypoglycemia risk.
   Suppress glucagon secretion: inhibits release of hyperglycemic glucagon to further control blood sugar.
   Delay gastric emptying: slow gastrointestinal digestion and flatten postprandial blood glucose spikes.
   Improve insulin resistance: enhance insulin sensitivity of peripheral muscle and adipose tissues.

3. Weight-loss mechanism 
   Acts on hypothalamic appetite center in the brain to curb appetite and cravings for high-calorie food, spontaneously lowering total food intake.
   Prolong satiety via delayed gastric emptying, extending the feeling of fullness.
   Regulate energy metabolism: slightly boost energy expenditure and reduce visceral fat accumulation.

4. Cardiorenal protective mechanism 
   Alleviate vascular burden by weight loss, lipid regulation and blood pressure reduction.
   Directly act on myocardium and vascular endothelium to exert anti-inflammatory and anti-oxidative effects, lowering cardiovascular event risks.
   Optimize renal blood flow and glomerular filtration, reduce urinary protein excretion to protect kidney function.

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