—— Product Specifications ——

—— Product Detail ——

Product Overview

Product Name: PyBOP ((1H-Benzotriazol-1-yloxy)tripyrrolidinophosphonium Hexafluorophosphate)

CAS No.: 128625-52-5

Molecular Formula: C₁₈H₂₈F₆N₆OP₂ 

Molecular Weight: 520.39 

MDL No.: MFCD00077411 

Synonyms: Benzotriazol-1-yl-oxytripyrrolidinophosphonium Hexafluorophosphate, 1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate, PyBOP

PyBOP (CAS 128625-52-5) is a highly efficient reagent widely used in amide bond formation synthesis. It appears as a white to off-white crystalline powder with a molecular weight of 520.39 and a melting point of 152-158°C .

With a purity of ≥98.0% by HPLC, PyBOP serves as an alternative to BOP coupling reagent but does not produce carcinogenic HMPA byproducts, making it a safer choice for peptide synthesis applications . The reagent is soluble in common organic solvents including dichloromethane, chloroform, DMF, DMSO, NMP, THF, acetonitrile, and acetone

Key Applications:

1. Pharmaceutical Research

Used in the synthesis of various pharmaceutical compounds, including:

• Natural product cyclopeptides (e.g., Dendroamide A, Cyclomarin C) 

• Macrolide synthesis (e.g., (-)-Spinosyn A) 

• Eight-membered lactone ring synthesis 

2. Organic Synthesis

Beyond peptide synthesis, PyBOP is also applied in:

• Phosphonate synthesis 

• Nitrile formation 

• Oxadiazole synthesis 

• Non-amino acid amide bond formation 

3. Solid-Phase Synthesis

Extensively used in solid-phase peptide synthesis assays for rapid and efficient coupling reactions

—— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: when will the shipment be arranged?
a: delivery within 5-10 days after receipt of advance payment. the specific delivery date is negotiated with the customer.

Q2: what is your standard of practice to ensure high quality of your products?
a: we follow a strict quality control of 6 steps testing from the beginning purchase of raw materials to the finished product.

Q3: how long can i expect to get the sample?
a: we will send the sample in 3-5 days. depends on your preferences, we can deliver via many express companies such as dhl, fedex, ups, tnt, etc. arrive within 5-7 working days.

Q4: what kind of payment terms do you accept?
a: we would like to accept 100% t/t in advance.usd,usdt,alipay,wechat pay and cash all acceptable.

Q5: what is the moq?
a: usually the min order quantity of 1kg can be used as a sample. the min quantity of general chemicals is 1kg. the min order quantity of special dangerous goods is 500KG.

Q6: how to control quality?
a: we have more than 10 years chemical exporting experience and we have customers all over the world, professional and strict quality control system helped us to stay alive in this market.

Q7: do you have stock?
a: most of products are under regular production, we can make delivery immediately.