1-(Quinolin-3-yl)ethanol 53531-33-2 98% off-white to light yellow solid pharmaceutical intermediate

1. Product Overview

1-(Quinolin-3-yl)ethanol (CAS 53531-33-2) is a quinoline-derived secondary alcohol featuring a hydroxyl-bearing ethanolic side chain at the 3-position of the quinoline nucleus. Also referred to as 1-quinolin-3-yl ethanol or 1-(3-quinolinyl)ethanol, it serves as a versatile chiral or achiral building block in medicinal chemistry and heterocyclic synthesis. The compound typically appears as an off-white to light yellow crystalline solid or powder, widely used for introducing the 3-substituted quinoline motif into active pharmaceutical ingredients (APIs) and bioactive molecules targeting CNS, antiviral, and anticancer research areas.

2. Key Features and Advantages

• Secondary alcohol functionality enables straightforward derivatization via oxidation to ketone, esterification, ether formation, or conversion to halides and amines.

• 3-Substituted quinoline scaffold is a privileged structure in drug discovery, supporting rapid SAR exploration for N-heteroaromatic libraries.

• High purity grade (≥98%) ensures reliable performance in sensitive coupling and multi-step pharmaceutical intermediate workflows.

• Compatible with standard protecting-group strategies (e.g., silylation of OH, quinoline N-oxidation/reduction) for orthogonal synthesis design.

• Stable solid form with well-established analytical profile (NMR, HPLC, MS) for QC release in R&D and custom synthesis projects.

3. Main Applications

• Pharmaceutical intermediate for quinoline-based drug candidates in antiviral, antibacterial, anticancer, and CNS therapeutic programs.

• Building block in medicinal chemistry for constructing 3-substituted quinolines, quinoline-containing spirocycles, and fused heterocycles.

• Intermediate in custom synthesis and CRO/CDMO projects targeting novel bioactive heterocyclic libraries.

• Used in academic and industrial research for method development in asymmetric alcohol oxidation/reduction, C–H activation at quinoline 3-position, and cross-coupling reactions.

• Precursor to 3-acetylquinoline derivatives via oxidation, which are themselves key intermediates in agrochemical and dye chemistry.

4. Technical Specifications

5. Storage and Handling

Store in a cool, dry place at 2–8 °C in a tightly sealed container protected from light. For long-term storage, keep at –20 °C under an inert atmosphere (nitrogen or argon) in desiccated conditions to prevent oxidation of the secondary alcohol and slow darkening of the solid. Avoid exposure to strong oxidizing agents, acidic/basic conditions that may promote dehydration or quinoline ring modification, and elevated temperatures. Handle in a well-ventilated area with standard PPE (lab coat, nitrile gloves, safety glasses). Reseal promptly after use. Under recommended conditions, shelf life is typically 24 months.

6. Safety Overview

Intended for research and synthetic use only; not for direct human or veterinary therapeutic administration. May cause mild irritation to eyes, skin, and respiratory tract upon contact or dust inhalation. Not classified as a GHS hazardous substance at typical lab scales, but treat as a fine organic solid with standard precautions. Prevent dust generation. In case of skin contact, wash with soap and water; for eye contact, rinse thoroughly with plenty of water and seek medical advice if irritation persists. Dispose according to local regulations for non-halogenated organic laboratory chemicals. Always consult the latest SDS from the supplier before use.