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I. Coreof DS5 (Dermaseptin S5， Frog Skin Antibacterial Peptide) Principle of action
Cationic amphiphilic α-helical peptides only target negatively charged microbial cell membranes without damaging the normal human cell membranes; upon contact with bacteria, they disintegrate the membrane structure, causing the leakage and inactivation of the bacterial contents, achieving broad-spectrum antibacterial and bactericidal effects.
Broad-spectrum antibacterial effect
They have inhibitory and inactivating effects on both Gram-positive and Gram-negative bacteria; they have particularly prominent inhibitory activity against common skin pathogenic bacteria (Staphylococcus aureus, Propionibacterium acnes, Escherichia coli), and are used for in vitro research as a skin antibacterial raw material.
Strong antifungal
They inhibit Candida albicans, dermatophytes, Aspergillus, etc.; in vitro experiments can reduce fungal proliferation, and are used for the research and development of raw materials for treating skin fungal problems.
Antiprotozoal activity
They can inhibit the reproduction of Leishmania and Plasmodium in vitro, used for the preliminary screening of antiparasitic drugs.
Membrane virus inhibition
They destroy the outer lipid membrane structure of enveloped viruses, reducing the ability of viruses to infect cells; for some herpes and enveloped viruses, they are used for in vitro antiviral mechanism research.
Skin anti-inflammatory and repair assistance (at the cellular level in vitro)
They eliminate the epidermal inflammatory factors induced by microorganisms, reduce oxidative stress of keratinocytes; reduce redness, itching, and damage caused by bacterial stimulation, assist in the stability of the epidermal barrier; do not damage normal skin cells, and have a much lower irritation level than traditional preservatives.
Potential of biological preservative substitution
Used in the laboratory for the development of non-irritating preservative systems for cosmetics and biological preparations, replacing irritating chemical preservatives.
Limitations
Effective only in vitro cell and tissue samples, without compliant oral or topical finished products; cannot penetrate deep into the dermis, only acting on surface microorganisms.
II. Product number annotation DS5 = DSIP (δ sleep-inducing peptide) neuroregulatory efficacy Principle of action
Endogenous neuropeptides act on the central nervous system's sleep regulation pathway, regulating the secretion of stress hormones in the hypothalamus and optimizing the rhythm of brain waves.
Deep sleep regulation
Increase the duration of delta slow-wave sleep, prolong deep restorative sleep; shorten the latency to fall asleep, improve frequent dreaming, light sleep, and easy awakening; stabilize the circadian rhythm, suitable for studies ， shift work， and disorders of the biological clock.
Stress and cortisol regulation
Downregulate cortisol secretion in the stress state， reduce chronic oxidative stress； alleviate emotional irritability and restlessness caused by long-term mental tension， used in in vitro neural model experiments for anxiety and high-pressure conditions.
Neuro-antioxidation and brain cell protection
Reduce the accumulation of reactive oxygen species in the brain， reduce neuronal oxidative apoptosis； in vitro brain tissue experiments can alleviate nerve cell damage caused by stress and hypoxia， used for basic research on brain fatigue and neurodegenerative problems.
Endocrine homeostasis balance
Gently regulate the hypothalamus-pituitary endocrine axis， reduce endocrine fluctuations caused by stress； indirectly assist in stabilizing metabolism and improving stress-induced fatigue.
Emotional relaxation and cognitive recovery
Improve attention and sluggishness caused by sleep deprivation； balance central inhibitory / excitatory signals， reduce hyperactive state of the nervous system.
Pain relief auxiliary research value
Regulate the central pain conduction pathway， have the potential to moderately alleviate neural discomfort in in vitro nerve tissue experiments.

Classification of the substance or mixture

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GHS label elements, including precautionary statements

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Hazard statement(s)	no data available
Precautionary statement(s)
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Other hazards which do not result in classification

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Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.