—— Product Specifications ——

—— Product Detail ——

• • • • • • • • Product Overview

                Amoxicillin trihydrate is a broad-spectrum beta-lactam antibiotic belonging to the aminopenicillin class, with the molecular formula C₁₆H₁₉N₃O₅S·3H₂O and a molecular weight of 419.45 g/mol. This white to off-white crystalline powder is one of the most widely prescribed antibiotics globally, used for the treatment of a variety of bacterial infections including respiratory tract infections, urinary tract infections, and skin infections.

                As a semi-synthetic penicillin derivative, amoxicillin features a hydroxy group on the phenyl ring that enhances its oral bioavailability compared to ampicillin. The trihydrate form ensures good crystallinity, stability, and processability during formulation. In research applications, it serves as a reference standard for antibiotic susceptibility testing, a model compound for studying beta-lactamase inhibition, and a precursor for the synthesis of pharmaceutical derivatives.

                Synthetic Process

                Amoxicillin trihydrate is manufactured through the following routes:

                • Enzymatic synthesis: 6-Aminopenicillanic acid (6-APA) is enzymatically coupled with D-p-hydroxyphenylglycine methyl ester using penicillin acylase (or other appropriate enzymes) to form amoxicillin.

                • Chemical synthesis: 6-APA is chemically acylated with a suitable acylating derivative of D-p-hydroxyphenylglycine under controlled conditions.

                • Crystallization: The resulting amoxicillin is crystallized as the trihydrate form under controlled conditions to obtain the final product.

                • Purification: The product is washed, dried, and milled to meet pharmaceutical specifications.

                Mechanism of Action / Application Principles

                • Antibacterial Activity: Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which are transpeptidases essential for the cross-linking of peptidoglycan chains. This leads to cell wall weakening and ultimately bacterial cell lysis.

                • Antimicrobial Spectrum: Active against a wide range of Gram-positive and Gram-negative bacteria, including Streptococcus species, Enterococcus species, Haemophilus influenzae, and Escherichia coli.

                • Susceptibility Testing: Used as a reference standard in antibiotic disc diffusion and broth microdilution assays for determining bacterial susceptibility.

                • Beta-Lactamase Studies: Serves as a substrate for studying beta-lactamase enzymes and evaluating beta-lactamase inhibitors.

— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.