—— Product Specifications ——

—— Product Detail ——

• • • • • • • • • • Product Overview

                    2-Amino-5-chloro-2'-fluorobenzophenone is a halogenated aminobenzophenone compound with the molecular formula C₁₃H₉ClFNO and a molecular weight of 249.67 g/mol. This yellow to orange-yellow crystalline powder is a key intermediate in the synthesis of various pharmaceutical compounds, particularly in the production of benzodiazepine derivatives and other psychoactive agents.

                    The compound features a benzophenone core with an amino group at the 2-position, a chlorine atom at the 5-position, and a fluorine atom at the 2'-position. This unique substitution pattern makes it an essential building block for the synthesis of pharmacologically active molecules, especially those targeting the central nervous system. The presence of both chlorine and fluorine atoms provides opportunities for further functionalization and structure-activity relationship studies.

                    Synthetic Process

                    2-Amino-5-chloro-2'-fluorobenzophenone is synthesized through the following routes:

                    • Friedel-Crafts acylation: 2-Aminochlorobenzene is acylated with 2-fluorobenzoyl chloride in the presence of a Lewis acid catalyst (such as aluminum chloride) to form the benzophenone structure.

                    • Reduction of nitrobenzophenone: The corresponding nitrobenzophenone is reduced to the amino derivative using hydrogenation or chemical reduction.

                    • Purification: The crude product is purified by recrystallization from ethanol, methanol, or suitable solvent mixtures.

                    Mechanism of Action / Application Principles

                    • Benzodiazepine Synthesis: This compound is a key intermediate in the synthesis of various benzodiazepine derivatives, which are widely used as anxiolytics, sedatives, and anticonvulsants.

                    • Pharmaceutical Building Block: Serves as a precursor for the synthesis of diverse bioactive molecules targeting the central nervous system.

                    • Structure-Activity Relationship Studies: The chloro and fluoro substituents allow for systematic SAR studies in drug discovery programs.

                    • Organic Synthesis: The amino group serves as a handle for further derivatization, including amidation, diazotization, and condensation reactions.

— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.