Powerful metabolic regulation capability Retatrutide triple agonist peptide for multi dimensional obesity mechanism related laboratory study analysis
TDS 7494 Inquiries
2381089-83-2
Pharmaceutical Grade
99%
Hong Kong
TRANMOO
5mg*10vials,10mg*10vials,15mg*10vials,20mg*10vials,30mg*10vials,60mg*10vials
Yes
2045-07-20
Retatrutide
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Product Details
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceRetatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively. It is an important tool for obesity research.Retatrutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GIP receptor (GIPR) or the GLP-1R.Retatrutide is a synthetic peptide with glucose-lowering effects. It is an antidiabetic agent against type 2 diabetes (T2D), stimulating insulin and suppressing glucagon secretion in a glucose-dependent manner.Retatrutide was also shown to delay gastric emptying, lower fasting and postprandial glucose concentration, decrease food intake and reduce body weight in patients with type 2 diabetes.
Retatrutide (LY-3437943) was discovered by the American pharmaceutical company Eli Lilly and Company. It is a triple glucagon hormone receptor agonist (GLP-1, GIP, and GCGR receptors) for obesity. The 2024 Lasker~DeBakey Clinical Medical Research Award has been given to Joel Habener and Svetlana Mojsov for their discovery of a new hormone GLP-1(7-37) and to Lotte Knudsen for her role in developing sustained acting versions of this hormone as a treatment for obesity.CertificatesBasic Info-
Product Name:
Retatrutide
Other Name:Retatrutide;GIPR/GLP-1R;LY3437943Retatrutide;Retalutide;Retatrutide (sodium salt);Retatrutide RT5;retatrutide 5mg;Retatratide
CAS No.:2381089-83-2
InChIKeys:MLOLQJNKXBNWFW-SAGGEDDASA-N
Molecular Weight:0
EC Number:200-001-8
Color/Form:White lyophilized
Categories:
Characteristics-
Water Solubility:
Soluble in water (5mg/ml).
Storage Conditions:-20°C
Critical Temperature & Pressure:-20°C
Research-
Class:
Triple agonist — GCGR, GIPR, GLP-1R
Status:Investigational (Phase 3)
Mechanism:Simultaneously activates glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Engineered from the native GIP backbone with amino acid substitutions to confer GCGR and GLP-1R activity.
EC50 (Human GCGR):5.79 nM
EC50 (Mouse GIPR):0.191 nM
EC50 (Mouse GLP1R):0.794 nM
EC50 (Mouse GCGR):2.32 nM
EC50 (Human GLP1R):0.775 nM
EC50 (Human GIPR):0.0643 nM
Source:Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526.DOI
Clinical Development:
References-
ChEMBL:DrugBank:KEGG DRUG:PubChem:Disclaimer:
Retatrutide is an investigational compound not yet approved by FDA or EMA. This listing is for industrial and laboratory research use only. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
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Seller Information
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Business Type:
Trader
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Main Products:
Retatrutide
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Location:
shenzhenshilonggangqulongchengjiedaohuanggekengshequjiazhaoyeshidaidasha902
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Average lead Time:
15 days
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Year of Establishment:
2024
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Inquiry History7494 Inquiries
Country Product Purchase Quantity Date Posted
Malaysia
Retatrutide
20 MG Oct 28, 2026
United States
retatrutide
30 MG Oct 28, 2026
Czech
Retatrutide
10 MG Oct 28, 2026
Austria
retatrutide
30 MG Oct 28, 2026
United States
Retatrutide
100 KG Oct 28, 2026
Malta
Retatrutide
10 MT Oct 28, 2026
United States
Retatrutide
600 MG Oct 28, 2026
United States
Retatrutide
500 G Oct 28, 2026
United States
Retatrutide
60 G Oct 28, 2026
Croatia
Retatrutide
10 MG Oct 28, 2026
United States
Retatrutide
200 MG Oct 28, 2026
Sweden
Retatrutide
10 MG Oct 28, 2026
United States
Retatrutide
1 G Oct 27, 2026
United Kingdom
Retatrutide
10 MG Oct 27, 2026
Lithuania
Retatrutide
30 MG Oct 27, 2026
United States
Retatrutide
10 MG Oct 27, 2026
Greece
Retatrutide
30 MG Oct 27, 2026
Germany
Retatrutide
20 MG Oct 27, 2026
Canada
Retatrutide
30 MG Oct 27, 2026
United States
retatrutide
40 MG Oct 27, 2026 Post an enquiry for this product
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