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II. Core: Local potent analgesia (mainly topical ointments / gels)
Highly selectively binds to peripheral μ-opioid receptors in skin, muscles, and joints, blocking the release of pain signaling substances (proteins, glutamate), inhibiting the discharge of pain nerve cells, and alleviating various chronic pains.
Muscle strain: Shoulder, neck, back, and spine fascia pain, delayed muscle soreness, joint movement pulling pain;
Neuralgia: Peripheral nerve stabbing pain, dermatitis itching and burning pain, postoperative superficial wound pain;
Inflammatory pain: Arthritis, sterile swelling pain of soft tissues, generalized wandering pain of fibromyalgia.
Reversing pain hypersensitivity: Long-term pain causes nerve sensitivity, slight touch causes stabbing pain. Topical application can down-regulate the NMDA, COX-2 sensitive pathways and reduce the sensitivity state of pain threshold.
Long-lasting analgesic effect: The receptor binding dissociation is slow. A single topical application can maintain analgesic effect for 12–24 hours, superior to common topical analgesic components.
II. Local anti-inflammatory and de-swelling (exclusive for topical use)
Inhibit the release of local TNF-α, IL-6 pro-inflammatory factors, reduce soft tissue sterile inflammation, synovial congestion and edema, alleviate joint swelling, skin redness and heat.
Reduce tissue fibrosis induced by inflammatory mediators, improve stiffness and tightness of chronic strain injuries, and the sensation of fascial nodules.
Reduce inflammatory exudation at the wound surface, assist in barrier repair of minor abrasions and dermatitis, alleviate inflammatory itching.
III. Emotional relaxation and improvement of pain-related insomnia (with weak effect on oral formulations only)
A small amount penetrates the blood-brain barrier and activates central μ-receptors, alleviating the irritability, anxiety, and physical tension caused by chronic pain persistence; reducing the disordered thoughts before sleep and difficulty in sleeping due to pain.
Improve shallow sleep and night awakenings caused by overall muscle soreness, extend the duration of deep rest, and reduce the heaviness and fatigue after waking up.
Slightly relieve neural stress, reduce persistent mental lethargy caused by long-term pain.
IV. Other auxiliary pharmacological effects (animal experiment conclusion)
Mild regulation of intestinal smooth muscle: Topical application to the abdomen and intestinal solubility modification can alleviate spastic intestinal colic and stress-induced irritable bowel syndrome abdominal pain, but the original ordinary oral form has no effect.
Mild antioxidation: Inhibit free radicals produced by pain inflammation, reduce local tissue oxidative aging damage.
Does not have common peptide effects such as muscle growth, fat reduction, immune enhancement, anti-aging, tanning, and mucosal repair, the core is only around analgesia, local anti-inflammatory.
V. Limitations of native peptide oral administration (key reminder)
Ordinary oral administration has almost no efficacy: Peptide ( will be rapidly decomposed by gastric acid and intestinal peptide enzymes， almost unable to enter the bloodstream and take effect； only special nano/sugar-modified formulations have weak oral activity in animal experiments， and there is no mature oral formulation for human use.
High safety risks (commonality of opioids)：
Overdose will inhibit breathing， dizziness， drowsiness， nausea， constipation， and urinary retention；
Long-term continuous use leads to tolerance， physiological dependence， and addiction tendency；
Low-dose drug effect is extremely strong， and dosage error is very likely to trigger respiratory depression， shock risk.
Not approved for routine human use by global drug regulatory authorities， only laboratory research reagents， not daily maintenance peptides； prohibited in horse racing competitions.

Classification of the substance or mixture

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GHS label elements, including precautionary statements

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Signal word	no data available
Hazard statement(s)	no data available
Precautionary statement(s)
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Other hazards which do not result in classification

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Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.