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Bicyclohexylammonium fumagillin powder

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CAS No.:

41567-78-6

Grade:

chemical grade

Content:

85%

Packaging:

100g/bag

Price valid (until):

2026-08-16

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Description
1. Treatment and Prevention of Nosema Disease in Honey Bees

Its most prominent, FDA-approved commercial use is as a specialized treatment in apiculture (beekeeping).

Targeting Nosema apis: It acts with high specificity against the single-celled parasite Nosema apis, which causes nosemosis (a severe digestive disease in western honey bees).

Disrupting the Parasite Gut Life Cycle: When dissolved into sugar syrup fed to bees, the drug prevents multiplying, reproductive stages of the parasite from attacking and destroying the epithelial cells of the bee's digestive tract. Note: It kills the active parasites but is not effective against dormant spores.

2. Inhibition of MetAP-2 Enzyme (Molecular Mechanism)

At a cellular level, the salt delivers the active fumagillin base to perform its primary biochemical function.

Irreversible Binding: It binds covalently to a specific amino acid (histidine) on the Methionine Aminopeptidase 2 (MetAP-2) enzyme.

Halting Protein Modification: By disabling MetAP-2, it blocks the cell's ability to remove the initial methionine from newly synthesized proteins, which cripples vital post-translational cellular processes in targeted pathogens.

3. Veterinary and Research Functions

Beyond honey bees, this stable salt variant acts as a foundational agent in broader microbiological contexts:

Aquaculture Microsporidia Control: It functions as an antimicrobial compound to treat destructive microsporidian infections across various fish species.

Angiogenesis Research: Because MetAP-2 inhibition halts the growth of new blood vessels (angiogenesis), this compound is utilized in laboratory oncology settings to study how tumor blood supplies can be cut off and starved.
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Basic Info

Product Name:
Bicyclohexylammonium fumagillin

Other Name:
Bicyclohexylammonium fumagillin;Fumagillin bicyclohexyl amine salt;fumagillin B;fumagillin bicyclohexylamine;Dicyclohexylamine salt;Fumagilin B;Fumagillin dicyclohexylamine salt;Fumamin

CAS No.:
41567-78-6

Molecular Formula:
C38H57NO7

InChIKeys:
OLRILZDTQKZQIG-UHFFFAOYSA-N

Molecular Weight:
639.87

Exact Mass:
639.41350316

EC Number:
200-001-8

Categories:
Bulk Drug Intermediates
Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
South Korea	Bicyclohexylammonium fumagillin 99.00%	10 KG	May 30, 2024
Australia	fumagillin b	5 KG	Jun 4, 2026

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Bicyclohexylammonium fumagillin powder

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