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creatine monohydrate /Pharmaceutical Grade | 99.9% Purity | CAS 6020-87-7

Name: creatine monohydrate /Pharmaceutical Grade | 99.9% Purity | CAS 6020-87-7
Brand: Orient
SKU: pr2607221322
Price: 33 USD
Availability: InStock

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CAS No.:

6020-87-7

Grade:

Pharmaceutical Grade

Content:

99.99%

Port:

shanghai

Brand:

Orient

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-08-22

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Creatine Monohydrate Specifications, Uses and Synthesis Method

Basic Properties

Melting Point: 292 °C (dec.)(lit.)

Density: 0.55-0.64 g/cm³

RTECS Number: MB7706000

Storage Condition: 2-8°C

Solubility: Slightly soluble in water, insoluble in ethanol and ether

Appearance: Crystalline powder

Color: White to off-white yellow

Odor: Odorless

pH Value: 6.9 (10g/L, H₂O, 20℃)

Water Solubility: 13 g/L (20 ºC)

Merck Index: 14,2568

BRN: 907175

Stability: Hygroscopic

Cosmetic Function: Skin conditioning

InChI: InChI=1S/C4H9N3O2.H2O/c1-7(4(5)6)2-3(8)9;/h2H2,1H3,(H3,5,6)(H,8,9);1H2

InChIKey: MEJYXFHCRXAUIL-UHFFFAOYSA-N

SMILES: N(C)(C(N)=N)CC(=O)O.O

LogP: -1.877 (est)

CAS Registry Number: 6020-87-7

NIST Chemical Information: Creatine hydrate (6020-87-7)

Introduction

Creatine is naturally synthesized from amino acids in the human liver and transported to muscle cells via blood circulation, where it is converted into creatine salt. Human muscle movement is powered by the decomposition of adenosine triphosphate (ATP). Creatine can moderately regulate moisture in muscle tissues, expand muscle cross-section and improve muscle explosive power. Relevant experimental studies have verified that creatine has multiple beneficial effects on human body.

Physiological Functions

Creatine is synthesized from amino acids in the human liver and delivered to muscle cells through blood, and converted into creatine salt in muscle cells. It provides energy support for human muscle movement via ATP decomposition. It can automatically adjust moisture entering muscles, expand muscle cross-section and enhance muscle explosive power. A large number of in vivo and in vitro experiments have confirmed that creatine has the following functions:

Increase creatine content in skeletal muscle and improve energy reserve capacity
Regulate glucose metabolism and reduce lactic acid production
Improve intramuscular glycogen storage
Enhance antioxidant capacity of the body

Applications

Synthetic creatine is widely used as a nutritional supplement to assist skeletal muscle adaptation to high-intensity exercise and relieve physical fatigue. It can be used as a raw material for health-care preparations and compound health food ingredients with body conditioning effects.

As a non-hormonal ingredient, creatine will not interfere with human endocrine system and cause dependence or adverse physiological reactions, so it is widely applied in health product industry. Natural creatine exists in a small amount in meat and fish products, which is insufficient for daily body conditioning needs, so supplementary intake of creatine monohydrate is commonly adopted to increase creatine content in skeletal muscle.

Creatine can be converted into phosphocreatine under the action of creatine kinase, expanding the phosphocreatine energy metabolism pool. Supplementary intake of creatine monohydrate can optimize creatine metabolism, improve body growth status and tissue quality, and has great application potential in health nutrition and animal husbandry fields.

In addition, creatine monohydrate can boost calcium uptake in sarcoplasmic reticulum, optimize the synthesis of myosin heavy chain and actin, support faster and stronger muscle contraction, help maintain lean body mass, and increase the cross-sectional diameter of muscle fibers, especially type II muscle fibers.

Chemical Properties

White crystalline or crystalline powder. Slightly soluble in water, insoluble in ethanol and ether. Hygroscopic under normal storage environment.

Main Usage

Used for biochemical research
Served as raw materials for daily health products and cosmetic additives
Applied in food and beverage additive industry for nutritional fortification
Help relieve physical fatigue, accelerate protein synthesis, improve muscle condition and body vitality

Synthesis Method

Raw material related CAS No.: 107-97-1, 7404-50-4, 6020-87-7

1. Dissolve 196g (2.2mol) N-methylglycine (sarcosine) in 360g of water, heat the solution to 80℃ to form a homogeneous transparent solution.

2. Rapidly add the above hot solution into the pre-prepared S-(carboxymethyl)isothiourea aqueous solution, control the feeding rate to keep the reaction temperature below 60℃.

3. Stir and react the mixture continuously at 60℃ for 3 hours to ensure sufficient reaction.

4. Stop heating after the reaction is completed, transfer the reaction system to an ice water bath and cool to 0-5℃ for crystallization.

5. Filter to collect white crystalline products, wash the filter cake with a small amount of absolute ethanol to remove impurities, and dry to obtain 238g creatine monohydrate (white crystal, melting point: 294℃) with a yield of 80%.

6. Extract the filtrate four times with 300ml chloroform, and combine all chloroform extract liquids.

7. Recover chloroform by atmospheric distillation, and conduct vacuum distillation of the residual substance under 0.098MPa.

8. Collect the distillate at 104-106℃ to obtain 156g mercaptoacetic acid with a yield of 85%.

References

[1] Patent: CN105777594, 2016, A. Paragraph 0025; 0026

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Certificates

Basic Info

Product Name:

Creatine monohydrate

Other Name:

N-GUANYL-N-METHYLGLYCINE;N-GUANYL-N-METHYLGLYCINE, MONOHYDRATE;N-METHYL-N-GUANYLGLYCINE MONOHYDRATE;N-AMIDINOSARCOSINE;N-AMIDINOSARCOSINE HYDRATE;N-AMIDINOSARCOSINE MONOHYDRATE;Glycine, N-(aminoiminomethyl)-N-methyl-, monohydrate;jisuanyisui

CAS No.:

6020-87-7

Molecular Formula:

C4H11N3O3

InChIKeys:

MEJYXFHCRXAUIL-UHFFFAOYSA-N

Molecular Weight:

149.15

BRN:

907175

EC Number:

611-954-8

TSCA:

Yes

Color/Form:

White to yellow

HScode:

29252000

Categories:

Blood Glucose Regulators

Characteristics

Density:

0.55-0.64 g/cm3

Melting Point:

292 °C (dec.)(lit.)

Water Solubility:

13 g/L (20 ºC)

Odor:

Odorless

PH:

6.9 (10g/l, H2O, 20℃)

Autoignition Temperature:

>800°C

Critical Temperature & Pressure:

2-8°C

See More Creatine monohydrate Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Creatine monohydrate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

72 Inquiries

Country	Product	Purchase Quantity	Date Posted
Brazil	CREATINE MONOHYDRATE CAS 6020-87-7	5 KG	Apr 1, 2026
United States	Creatine monohydrate 99.5% White crystal or crystalline powder 6020-87-7 DeShang	1 40' Fcl	Oct 4, 2023
Egypt	Creatine monohydrate	1000 KG	Jul 18, 2024
United States	Creatine Monohydrate	1 KG	Apr 10, 2024
Slovenia	Creatine Monohydrate	1 MT	Jun 11, 2024
Denmark	Creatine monohydrate	1 KG	Jul 11, 2026
United Kingdom	creatine monohydrate	50 KG	May 4, 2026
Brazil	Creatine Monohydrate	1000 KG	Apr 19, 2026
Germany	Wholesale Bulk Pure Raw Creatine Powder 200 Mesh Creatine Monohydrate	25 KG	Mar 18, 2026
India	Creatine Monohydrate	15.00 MT	Feb 27, 2026
India	Creatine monohydrate	15.00 MT	Feb 24, 2026
Egypt	Creatine Mono	1000.00 MT	Dec 24, 2025
Egypt	Creatine Mono200mesh	1000.00 KG	Nov 20, 2025
India	Creatine monohydrate	3 MT	Nov 19, 2025
Egypt	Creatine monohydrate	12 MT	Sep 30, 2025
Bangladesh	Monohydrate Powder Creatine	1 KG	Jul 25, 2025
Colombia	Creatine monohydrate	118 KG	Jul 5, 2025
Poland	creatine monohydrate	1000 KG	May 20, 2025
Uruguay	Creatine monohydrate	5 KG	Apr 27, 2025
Germany	Creatine monohydrate	1 KG	Nov 11, 2024

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