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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Repaglinide for Sale > Research Grade Repaglinide Meglitinide Raw Powder
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Research Grade Repaglinide Meglitinide Raw Powder

TDS

Unit Price:

$68/UNIT FOB

Get Latest Price
CAS No.:

135062-02-1

Grade:

Reagent Grade

Content:

99%

Port:

shenzhen

Brand:

QY

Packaging:

10mg

Price valid (until):

2027-06-16

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Retatrutide,Tirzepatide,Semaglutide,GHK-CU

  • Product Description

  • Seller Information

  • Description
    Items Specifications
    Product Name Repaglinide
    CAS No 135062-02-1
    Molecular Formula C₂₇H₃₆N₂O₄
    Molecular Weight 452.59
    Grade Reagent Grade
    Purity 99
    Appearance White to off-white crystalline powder
    Storage Condition -20℃ sealed, dry and protected from light

    We are a professional pharmaceutical raw material factory integrating R&D, production and global supply. Repaglinide belongs to meglitinide compounds, widely used as laboratory research raw material for diabetes related pharmacology, glucose metabolism and pancreatic cell signal pathway research. This high-purity crystalline powder is supplied for pharmaceutical laboratories, university pharmacology research teams and drug formulation development institutions all over the world. This product is exclusively for laboratory scientific research only, and cannot be used for human medication, clinical treatment, finished drug production or food processing. All experimental operations must follow standardized laboratory safety specifications.Product Advantages

    1. High Purity & Stable Quality for Pharmacological Research

      Repaglinide acts as classic reference compound for anti-diabetic drug research. It targets potassium channels on pancreatic beta cells and regulates insulin secretion, which is widely studied in glucose homeostasis and metabolic mechanism research. Massive pharmacological research papers adopt Repaglinide as experimental material. Strict crystallization process effectively improves chemical stability, reducing impurity generation during storage and guaranteeing consistent experimental repeatability. Long-term stable chemical property makes it suitable for long-cycle cell incubation and continuous pharmacodynamic verification experiments.
    2. Complete and Strict Batch Quality Control System

      Every production batch undergoes full-range quality inspection before delivery. High-performance liquid chromatography (HPLC) is adopted for purity quantitative analysis, and electrospray ionization mass spectrometry verifies molecular weight to confirm structural consistency. Standard Certificate of Analysis (COA) containing comprehensive test records can be provided upon customer request. All testing indicators including moisture content, residual solvent, single impurity distribution comply with international testing standards for laboratory pharmaceutical raw materials. Each batch retains sealed reserve samples for long-term traceability to support repeated scientific research verification for global research teams.
    3. Good Dissolution Performance for In Vitro Pharmacology Tests

      The crystalline powder can dissolve in commonly used organic solvents and aqueous buffer systems for cell experiments. The prepared stock solution can be diluted according to diversified experimental concentration gradients for pancreatic cell incubation, insulin secretion detection and in vitro drug efficacy evaluation. It brings low interference to cell culture environment and pharmacodynamic model research, effectively improving the stability and reproducibility of experimental data.
    4. Flexible Customized Packaging & Stable Global Supply

      Standard packaging specifications are kept in continuous stable stock. Customized weight, external label and packaging schemes are supported to satisfy diversified research project demands. Moisture-proof, light-proof outer packaging ensures safe transportation during international sea and air logistics. Flexible order quantity meets small-scale laboratory trial research and large-scale repeated testing demands. We provide stable supply cycle and timely logistics arrangement for overseas research clients.

    Main Research Application Fields

    ✅ Pharmacological mechanism research of insulin secretion regulation

    ✅ Glucose metabolism and type 2 diabetes related basic research

    ✅ Pancreatic beta cell physiological function study

    ✅ In vitro cell pharmacodynamic screening and drug analog comparison research

    ✅ Formulation research of oral hypoglycemic active substances

    ✅ Exploration of potassium channel related signal transduction pathways

    Complete Quality Control Standards

    1. Purity Test: HPLC detection, total purity ≥99.0%, maximum single unknown impurity ≤0.5%
    2. Structure Identification: ESI-MS identification, measured molecular weight consistent with theoretical value
    3. Water Content: Tested by Karl Fischer titration, moisture ≤0.5%
    4. Appearance Characteristic: Uniform white to off-white crystalline powder without caking, agglomeration or discoloration

    Storage, Transportation & Safety Operation Instructions

    1. Storage Tips: Keep the package tightly sealed immediately after sampling. Avoid frequent repeated freezing and thawing cycles, which will accelerate chemical degradation. It is strongly recommended to divide prepared stock solution into multiple small independent aliquots and store at -20℃ for long-term preservation.
    2. Transportation: Small orders adopt sealed moisture-proof packaging; cold-chain constant temperature transportation can be selected as optional service for bulk orders or ultra-long-distance cross-border shipment routes.
    3. Operation Guidelines: All operators must wear complete set of protective equipment including nitrile protective gloves, long-sleeve lab coat and safety goggles during handling. Strictly prevent dust inhalation and direct contact with human skin and mucous membrane. In case of accidental contact, flush the contacted area sufficiently with plenty of clean running water immediately.
    4. Important Disclaimer: This product is FOR LABORATORY SCIENTIFIC RESEARCH ONLY. Any therapeutic application for human beings or experimental animals is strictly prohibited. All purchasers and users shall bear all corresponding legal liabilities for any improper application beyond the scope of scientific laboratory research.
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    ECHEMI Editorial Reference
    White crystalline powder, odorless. Crystallization from ethanol-water (2:1), melting point 126-128℃. Crystallization from neutral water, melting point 130~131℃. [α]D20+6.97℃ (C=0.975, methanol); [α]D20+7.45°(C=1.06, methanol). Acute toxicity LD50. Rat (g/kg): > 1 oral.
    Solid
    Repaglinide is a member of piperidines.|Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those naïve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. In addition to reducing postprandial and fasting blood glucose, meglitnides have been shown to decrease glycosylated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones. Repaglinide is extensively metabolized in the liver and excreted in bile. Repaglinide metabolites do not possess appreciable hypoglycemic activity. Approximately 90% of a single orally administered dose is eliminated in feces and 8% in urine.|Repaglinide is a Glinide. The mechanism of action of repaglinide is as a Potassium Channel Antagonist.|Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare instances of clinically apparent acute liver injury.|Repaglinide is a nonsulfonylurea insulin secretagogue belonging to the melgitinide class with hypoglycemic activity. Repaglinide is rapidly absorbed and has a rapid onset and short duration of action. This agent is metabolized in the liver by CYP2C8 and CYP3A4 and its metabolites are excreted in the bile. Repaglinide has a half-life of one hour.

    Certificates
    • Research Grade Repaglinide Meglitinide Raw Powder Certificates 1 TDS

    Basic Info
    Product Name:

    Repaglinide

    Other Name:

    Benzoic acid,2-ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]-;Benzoic acid,2-ethoxy-4-[2-[[3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]-,(S)-;2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid;Repaglinide;AG-EE 623ZW;Prandin;NovoNorm;(S)-(+)-2-Ethoxy-4-[[[N-[1-(2-piperidinophenyl)-3-methylbutyl]amino]carbonyl]methyl]benzoic acid;AGEE 623;Novolon;Eurepa;(S)-(+)-Repaglinide;GlucoNorm;Europa 0.5;Europa 1;(S)-2-Ethoxy-4-[2-[[3-methyl-1-[2-(piperidin-1-yl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid;Enyglid

    CAS No.:

    135062-02-1

    Molecular Formula:

    C27H36N2O4

    InChIKeys:

    InChIKey=FAEKWTJYAYMJKF-QHCPKHFHSA-N

    Molecular Weight:

    452.59

    Exact Mass:

    452.59

    EC Number:

    1312995-182-4

    UNII:

    668Z8C33LU

    NSC Number:

    759893

    DSSTox ID:

    DTXSID3023552

    NCI Thesaurus Code:

    C47703

    ATC Code:

    A10BX02|A - Alimentary tract and metabolism

    HScode:

    2933399090

    Characteristics
    PSA:

    78.9

    XLogP3:

    5.9

    Appearance:

    white solid

    Density:

    1.137±0.06 g/cm3(Predicted)

    Melting Point:

    132 °C

    Boiling Point:

    672.9°C at 760 mmHg

    Flash Point:

    360.8ºC

    Refractive Index:

    1.567

    Water Solubility:

    DMSO: 34 mg/mL

    Storage Conditions:

    2-8°C

    Vapor Pressure:

    5E-19mmHg at 25°C

    Toxicity:

    LD50 orally in rats: >1 g/kg (Grell)

    Specific rotation:

    D20 +6.97° (c = 0.975 in methanol); D20 +7.45° (c = 1.06 in methanol)

    Hazard Identification

    Classification of the substance or mixture

    Reproductive toxicity, Category 2

    Reproductive toxicity, Additional category for effects on or via lactation

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H361 Suspected of damaging fertility or the unborn child

    H362 May cause harm to breast-fed children

    H412 Harmful to aquatic life with long lasting effects

    Precautionary statement(s)
    Prevention

    P203 Obtain, read and follow all safety instructions before use.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P263 Avoid contact during pregnancy and while nursing.

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P273 Avoid release to the environment.

    Response

    P318 IF exposed or concerned, get medical advice.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Retatrutide,Tirzepatide,Semaglutide,GHK-CU

    Location:

    Plot 1, No. 205 Tongbao Road, Jiangdong Subdistrict, Yiwu City, Jinhua City, Zhejiang Province

    Payment Terms:

    TT against B/L draft before shipment,100% TT in advance

    Year of Establishment:

    2026

  • Country Product Purchase Quantity Date Posted
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