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Adamax, an analogue of Semax, has a adamantane portion similar to P21. Over time, Adamax can help humans improve endurance, speed recovery from strenuous exercise, and stimulate brain activity.
Due to its unique adamantane composition and increased bioactive stability after crossing the blood-brain barrier (BBB), Adamax improves the endurance of athletes by 2-3 times more than other Semax analogs. It increases brain-derived neurotrophic factor (BDNF) levels and enhances hippocampal TrkB receptor sensitivity.
ADA5 Adamax is a new type of modified puzzle peptide with great research value in the field of neurocognitive research. Based on the dual molecular modification of acetyl + adamantane, compared with traditional Semax, it has stronger stability, higher blood-brain barrier penetration efficiency, and more prominent neuroprotective activity. The unique advantages are widely used in cell and animal experiments related to brain injury, cognitive repair, emotional regulation, and exercise recovery. Based on years of experience in the synthesis and purification of modified peptides, Kangtai has created a scientific research-grade ADA5 Adamax freeze-dried powder with stable purity, low endotoxin and strong batch consistency. The standardized sterile Xilin bottles are packaged and matched to improve the full-link quality inspection system, which fully adapts to the various early mechanism research and development needs of scientific research laboratories, biomedical research and development enterprises and sports physiology research institutions in colleges and universities. At the same time, supporting professional peptide technical guidance, a full set of compliance qualification documents, and flexible customized supply services are stable and high-quality raw material selection for central nervous system-related target experiments.
The core mechanism of action
Adamax takes the classical neuropeptide Semax as the parent chain, and superimposes the dual structure modification of acetyl and adamantane. The adamantane group greatly enhances the molecular fat solubility and breaks through the short board that ordinary peptides are difficult to penetrate the blood-brain barrier ; acetyl modification resists protease hydrolysis in vivo and prolongs the molecular half-life. After entering the central nervous system, the expression of BDNF brain-derived neurotrophic factor is up-regulated, the sensitivity of TrkB receptor in hippocampus is improved, and the HPA hypothalamus-pituitary-adrenal axis is synchronously regulated to achieve the synergistic effect of multiple pathways of neuroprotection, cognitive regulation, anti-oxidation and anti-inflammation.
1.Research directions related to neurocognition and intelligence
Promote neuroplasticity and synaptic regeneration : up-regulate the secretion of BDNF in brain tissue, stimulate the proliferation of dendritic spines in hippocampal neurons, and build a new brain neural connection network, which is mostly used in the study of animal models related to learning and memory ability, and improve the spatial memory impairment caused by aging.
Strong blood-brain barrier penetration : Compared with unmodified Semax, the central bioavailability was significantly improved, and the extremely low drug concentration could act on brain lesions, which was the preferred tool peptide for brain target experiments.
Neuronal anti-apoptosis, brain injury repair : for cerebral ischemia, traumatic brain injury model, reduce the level of oxidative stress in brain tissue, reduce neuronal apoptosis ; it is also used for glaucoma, optic nerve injury-related retinal ganglion cell protection experiments.
Regulating emotions and alleviating neuroanxiety : Regulating the secretion of HPA hormones and down-regulating pro-inflammatory factors in the brain. In animal experiments, it shows the research value of stabilizing emotions and relieving stress anxiety, which is suitable for depression and chronic stress-related neurological subjects.
About Us KANGTAI Company Profile
Kangtai is a modern biopharmaceutical raw material enterprise with deep research and development, large-scale production and global supply of biopeptide raw materials. It has long focused on the whole industrial chain layout of functional peptides, medical active peptides and metabolic management peptide raw materials. It has independent peptide synthesis laboratory, standardized clean production workshop and complete three-level quality inspection center.
The core team of our company is composed of professional and technical personnel of biochemistry, peptide synthesis and pharmaceutical preparations. We have accumulated rich practical experience in solid-phase synthesis, purification, freeze-drying and stable preparation development of long-chain peptides. We are proficient in the process optimization of GLP-1 / GIP target peptides, and can stably produce high-purity tierpo peptide and other weight-loss metabolic active peptide raw materials.
The whole production process follows the ISO9001 quality management system and cGMP production specification, and establishes a full-link control standard from raw material storage, synthesis and purification, liquid phase quality inspection, aseptic freeze-drying to finished product packaging. It can provide standardized high-purity polypeptide raw materials, customized synthesis and technical formula matching one-stop service for domestic and foreign pharmaceutical research and development institutions, health preparation factories and biological research laboratories. The products are long-term supply to the domestic and foreign scientific research and preparation development market, and have been recognized by long-term cooperative customers with stable purity, batch consistency and perfect quality inspection report.
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