Cosmetic peptide 50mg* vials GHK Cu anti-aging raw material Anti-wrinkle 49557-75-7

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GHKCU 

   GHKCU (often written as GHK-Cu / Blue Copper Peptide / Tripeptide-1 Copper) is a blue active peptide formed by the complexation of the glycine-histidine-lysine tripeptide with copper ions. It is a classic ingredient in the fields of skin care and regeneration. Core functions (skin care + repair).
   Anti-aging and firming (promote collagen) Repair and regeneration (wound healing) Accelerate epidermal and dermal repair, promote angiogenesis, shorten healing time, reduce scarring; acne mark repair. Antioxidant and anti-inflammatory. Whitening and fading spots (auxiliary) Scalp and hair care.
   Activate hair follicles, extend growth period, reduce hair loss, increase hair volume and density, improve fine and soft hair quality.

   The copper peptide GHK is a tripeptide having the primary structure Gly-L-His-L-Lys. It is a natural chelator with a high affinity for  Cu2+. The resulting complex is commonly referred to as GHK-Cu. It was first isolated from human plasma, but is also present in saliva and urine.

    Copper peptides are generally small protein fragments with a high affinity for cations. Plasma GHK-Cu levels at age 20 are about 200 µg ml-1, but drop to 80 µg ml-1 at age 60. In humans, GHK-Cu promotes wound healing, stimulates glycogen and glycosaminoglycan synthesis in skin fibroblasts and blood vessel growth, has anti-inflammatory and antioxidant properties, and attracts immune system cells. Recent studies have shown that it can modulate the expression of a large number of human genes, generally by restoring the expression of these genes corresponding to the healthy state. Synthetic GHK-Cu is used in cosmetics and as an ingredient in so-called “repairing” and “anti-aging” products.

   In studies on the affinity of GHK for copper, where the histidine residue was replaced by a synthetic amino acid, it was shown that the glycine residue plays an essential role in copper binding, while the lysine residue can interact with copper only in basal. At physiological pH, lysine can interact with a cell receptor. Thanks to GHK's ability to interact with both copper and a cellular receptor, it can transport copper in and out of cells. The small size of the GHK molecule allows it to circulate rapidly in the extracellular space and easily access cellular receptors.

   The structure of the GHK-Cu complex has been studied in detail by X-ray crystallography, electron paramagnetic resonance, X-ray absorption spectrometry, NMR spectroscopy or even by titration. In this complex, the Cu2+ cation is coordinated to the imidazole of the side chain of the histidine residue, and to the atom of the deprotonated peptide bond between glycine and histidine residues. Insofar as such a structure does not explain the great stability of this complex, whose decimal logarithm of the dissociation constant is worth log10(K) = 16.44, against 8.68 for the GH-Cu complex, which is similar in structure to the GHK-Cu complex, it has been suggested that another GHK atom is involved in stabilizing the complex with copper. It could be the carboxylic oxygen atom of the lysine4 residue.

    Many researchers have proposed that GHK-Cu complexes form dimers and trimers at physiological pH which may include a histidine residue and/or the copper binding region of the albumin molecule. The dissociation constant of the complex formed with copper is log10(K)=16.2 with plasma albumin versus 16.44 with GHK.

Hainan Terte New Materials Co., Ltd. It is located in Hainan Province, China, with well-developed land transportation and convenient sea transportation. We focus on the sales and practical application of chemical raw material products. We adhere to the business philosophy of "be a good person first, then do good deeds", with the aim of putting customers first.

We always put the value of our customers as our top priority, we focus on high quality, competitive price, flexible order quantity, timely delivery. Our products are mainly exported to European countries, the United Kingdom, the United States, Canada and Australia. Our products are widely recognized and trusted by users.

We have our own delivery line to Canada, USA, UK, Spain, Poland, Netherland, Germany, Russia, Kazakhstan, Ukraine, etc. Door to door without any customs clearance issues.

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Q1: About the after-sale service

A: After purchasing the products from our Lab, we have A professional technical team and after-sales team to serve you and solve all your problems in the future

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A: We understand most customers prefer stock, so we'll try to keep stock for most products. However, for some rare products, we won't keep stock and it needs time to synthesize.

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You can send us your product specifications and requirements and we can customize for you.

Q5: What is your MOQ?

A: The minimum quantity we can order is 1 box.

But usually we can accept a smaller quantity, say 100g, at the cost of 100% sample charge.

Q6: Time for delivery?

A: Leading time within 1-3 business days,Shipping time about 8-10 business days. 

Q7: Why should I choose you?

A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over 5years, in average.Strict quality control-comes form our sophisticated management system.Professional and warm sales team-since we believe we can only win via our hard work in a competitive world.Quick response and excellent presale and after sale service-since we believe our customers deserve all the best service.