Thymulin, alternatively referred to as thymic factor, and formerly named facteur thymique serique, is categorized as a nonapeptide. This substance is synthesized by two separate epithelial cell populations located within the thymus. It was initially characterized and documented by Bach back in 1977.
This peptide hormone participates in the differentiation process of T cells and helps strengthen the functional activity of T cells and NK cells. Apart from these paracrine and local regulatory impacts on the thymus-dependent immune network, thymulin also displays observable neuroendocrine-related properties.
A mutual bidirectional regulatory relationship exists between thymic epithelial tissue and the hypothalamus-pituitary axis. Continuous research indicates constant signal communication taking place between these two systems, enabling coordinated biological regulation.
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