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Retatroptide (LY3437943) - High-Purity Research-Grade Triple Receptor Agonist Peptide

Retatroptide (CAS No.: 2381089-83-2), also known as LY3437943, is a revolutionary synthetic peptide and the world's first triple agonist targeting glucagon-like peptide-1 receptor (GLP-1R), gastric inhibitory peptide receptor (GIPR), and glucagon receptor (GCGR) to enter Phase III clinical trials. As a high-quality research-grade biochemical reagent, retatroptide has become the gold standard for metabolic research, obesity research, and diabetes mechanism exploration in laboratories, research institutions, and biotechnology companies worldwide due to its superior purity, reliable stability, and unique triple receptor activation mechanism. It is important to emphasize that this product is for in vitro research use only and must not be used for human or animal treatment.

Core Product Advantages

Our Retatrutide stands out in the highly competitive research peptide market with four unparalleled advantages:

Ultra-high purity and authentication: Each batch is guaranteed to have HPLC purity ≥99.0%, with no single impurity content ≤0.5%, and is dual-verified by HPLC and mass spectrometry (MS) analysis. Independent third-party testing by Janoshik Analytical, a leading peptide assay laboratory, ensures impartial verification of purity and molecular identity.

Triple receptor activation advantage: Unlike single or dual agonists, Retatrutide simultaneously activates three key metabolic receptors, providing researchers with a powerful tool to study the synergistic effects of energy metabolism, appetite, and glucose homeostasis. This unique mechanism enables groundbreaking research in complex metabolic pathways.

Excellent stability and solubility: The product is a lyophilized white to off-white powder with optimal stability under proper storage conditions. It is readily soluble in sterile water or 1% acetic acid solution (~1 mg/mL), ensuring easy preparation of research solutions without precipitation or aggregation.

Strict quality control: Rigorous testing is conducted for bacterial endotoxins (<0.5 EU/mg), total heavy metals (<10 ppm), and microbial contamination (sterility) to ensure the product is suitable for high-precision cell culture and in vivo preclinical studies. The manufacturing process strictly adheres to GMP standards and is carried out in an ISO-certified facility to ensure batch-to-batch consistency.

Wide Range of Applications

Ritatrotide's unique triple receptor activation properties make it indispensable in multiple research areas:

Metabolic Pathway Research: Ideal for investigating integrated signaling pathways involving GLP-1, GIP, and glucagon, providing insights into energy expenditure, lipid oxidation, and glucose-dependent insulin secretion.

Obesity and Weight Management Research: Facilitates research into appetite suppression, delayed gastric emptying, and weight regulation mechanisms; preclinical data show up to 24.2% weight loss in obese subjects.

Type 2 Diabetes Research: Helps explore mechanisms of glycemic control, enhanced insulin sensitivity, and potential therapeutic targets for diabetes and its complications.

Non-Alcoholic Fatty Liver Disease (NAFLD) Research: Supports research on lipid metabolism regulation and reduction of hepatic fat accumulation.

Peptide Engineering and Drug Discovery: Can serve as a benchmark for developing novel multi-receptor agonists and conducting structural comparative studies.

Quality Assurance and Service Commitment

Our manufacturing processes strictly adhere to ICH guidelines and international pharmacopoeia standards, with comprehensive quality control at every stage from synthesis to final packaging. Each batch of product comes with a detailed Certificate of Analysis (COA), including HPLC purity chromatograms, mass spectrometry identification results, endotoxin test results, and a microbial contamination report.

We offer global cold chain shipping to ensure product stability during transit and provide eligible research institutions with a free 50μg trial sample to evaluate product performance before bulk orders. Our professional technical support team is available 24/7 to provide you with product specifications, reconstitution instructions, storage recommendations, and guidance for research applications.

For researchers dedicated to elucidating the complex interactions of metabolic pathways, our Retatrutide offers unparalleled quality, reliability, and scientific value. Collaborate with us to accelerate your research breakthroughs in the treatment of metabolic diseases and obesity.