PE 22-28 /99% purity/ 10mg PE10/ Neuroprotection

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        PE 22-28 is a heptapeptide (composed of 7 amino acids) with the chemical sequence Gly-Val-Ser-Trp-Gly-Leu-Arg and a CAS number of 1801959-12-5. It was initially developed as a truncated analog of the antidepressant peptide "Spadin" (PE 12-28), and its core function is to act as a highly selective inhibitor of the TREK-1 potassium ion channel.

Physical Properties

• Appearance: White powder solid.
• Molecular Formula and Molecular Weight: C₃₅H₅₅N₁₁O₉, with a molecular weight of 773.88 g/mol.

Chemical Properties

• Structural Characteristics: It belongs to the class of polypeptide compounds, containing multiple amide bonds and side-chain functional groups, making it susceptible to proteolytic degradation.
• Solubility: It is generally soluble in water or buffer solutions, with specific solubility depending on pH and ionic strength; it has poor solubility in organic solvents.
• Stability: It is sensitive to heat, light, and enzymes, requiring low-temperature storage in the dark to prevent degradation.

Mechanism of Action
    The core pharmacological effect of PE 22-28 is serving as a highly selective inhibitor of the TREK-1 potassium channel, with an IC50 value as low as 0.12 nM, indicating an exceptionally strong binding affinity. TREK-1 is a two-pore domain potassium channel widely expressed in the central nervous system, heart, and peripheral tissues, playing a role in regulating neuronal excitability, emotional behavior, and pain perception.

   In depression research, the inhibition of TREK-1 can produce rapid antidepressant-like effects. The underlying mechanisms may involve:

•    Enhancing Neuronal Excitability: By blocking potassium efflux, it makes neurons more prone to depolarization, thereby promoting the release of neurotransmitters.
•    Modulating the 5-HT System: It interacts with the serotonergic pathway, mimicking some of the effects of SSRI-class drugs but with a faster onset of action.
•    Influencing the Sortilin/NTSR3 Pathway: Sortilin is the precursor protein of Spadin and is also involved in regulating the membrane localization of TREK-1. PE 22-28 may indirectly enhance antidepressant effects by interfering with this pathway.

      The core principle for storing parenteral lyophilized powder is strict refrigeration and absolutely no freezing. Before reconstitution, it is generally stored in the dark at 2 to 8°C. Once mixed and dissolved with the solvent, it must be used within a very short period.

Before Reconstitution (Original Packaging)

Strict Refrigeration: The vast majority of parenteral lyophilized powders need to be stored in a refrigerator at 2 to 8°C.

Absolutely No Freezing: Freezing will cause irreversible damage to the structure of proteins and peptides.

Protection from Light and Moisture: The product must be kept in its original packaging to avoid direct sunlight and accidental exposure to moisture.

After Reconstitution (Mixed State)

Highly Time-Sensitive: Once the lyophilized powder is dissolved with a sterile solvent, the stability of the drug drops significantly. It usually needs to be administered immediately or within a very short window (e.g., a few hours).

No Prolonged Storage: Under no circumstances should the reconstituted solution be stored in the refrigerator for use the next day. This can easily lead to loss of efficacy or severe bacterial contamination.

 * We will ship your order within 24–48 hours after payment is received.

 * We have dedicated shipping routes, allowing us to select the fastest and safest carrier for your specific destination—including FedEx, UPS, China Post, and other international express services. The estimated delivery time is approximately 7–15 business days.

 * We will also track the logistics throughout the entire process and update the logistics information for buyers in real time.

          Our company is located in Zhejiang Province and is a Chinese enterprise specializing in the production of peptide products.We are not intermediaries or resellers; we are the original manufacturer. This allows us to offer you the most competitive pricing. Our motto is: to manufacture products with care and serve customers with dedication.We are dedicated to serving every visitor with heart. No matter where you come from, you will experience our premium VIP service. We guarantee that every customer receives only the finest products, backed by exceptional after-sales support, as we strive to ensure your complete satisfaction.

1. What's the payment methods?
We could accept pay through Alipay, USDT, BTC and TT.

2.Does the product have a test report?
Each batch of our products undergoes testing before leaving the factory, and a Certificate of Analysis (COA) report is issued.

3.Can customers customize their own labels?

Custom labeling services are available. Please contact us to discuss your specific requirements prior to placing an order.

4.What is the product's shelf life?

When unopened, our products have a shelf life of two years under both room temperature and frozen storage conditions. Therefore, you can rest assured that extended shipping times will not cause the product to expire or degrade.

1.  * Ultra-High Purity Guaranteed
   Every batch is synthesized and purified to >99% purity, delivering the reliability and reproducibility your sensitive experiments demand.
2.  
3. * Precision Dosing & Batch Consistency
   Peptides are accurately weighed and vacuum-sealed under sterile conditions. We enforce rigorous quality control to ensure unwavering consistency from batch to batch.
4.  
5. * Endotoxin-Free & Sterile Assurance
   Produced in a certified cleanroom, our peptides are rigorously tested to be free of endotoxins, microbes, and impurities—safeguarding the integrity of your cell-based and in vivo studies.