The high-purity 5AM product is a high-purity peptide powder - 5AM - without any additives, fast delivery

Sales mannager: Amy

whatsapp:+852 5592 3505

Email:Amy@xtmingheng.com

5-Amino-1MQ exerts its biological effects primarily through selective inhibition of nicotinamide N-methyltransferase (NNMT), which triggers a cascade of metabolic changes at the cellular level:
1. NNMT Enzyme Inhibition
Acts as a competitive, substrate-site inhibitor of NNMT with an IC₅₀ of approximately 1.0–1.2 µM, blocking the enzyme that normally consumes both nicotinamide and S-adenosylmethionine (SAM).
2. Elevates NAD⁺ Levels
By preventing NNMT from diverting nicotinamide into 1-methylnicotinamide (1-MNA), it preserves nicotinamide for the NAD⁺ salvage pathway, increasing intracellular NAD⁺ — a critical cofactor for mitochondrial energy production, DNA repair, and cellular redox balance.
3. Restores SAM Methyl Donor Pools
NNMT acts as a "methyl sink" by consuming SAM. Inhibiting it restores cellular SAM levels, supporting proper histone methylation, gene expression regulation, and overall methyltransferase activity.
4. Promotes Fat Oxidation Over Storage
Shifts adipocyte (fat cell) metabolism away from lipogenesis (fat storage) and toward oxidative metabolism — increasing fat breakdown and energy expenditure rather than accumulating fat.
5. Increases Energy Expenditure
Preclinical studies show that NNMT inhibition in adipose tissue leads to higher basal metabolic rate and increased calorie burning, with some research suggesting elevations of 15–25% in energy expenditure without changes to diet or exercise.
6. Activates SIRT1 Pathway
Elevated NAD⁺ levels support the activation of SIRT1 (sirtuin-1), a NAD⁺-dependent deacetylase often called the "longevity regulator," which is linked to metabolic health, cellular protection, and energy regulation.
7. Supports Metabolic Health
Associated with improved insulin sensitivity, balanced blood sugar levels, reduced risk of metabolic dysfunction, and body-weight regulation in preclinical models.
8. Preserves Lean Muscle Mass
Unlike appetite-suppressing weight-loss compounds, 5-Amino-1MQ targets fat cells directly and is associated with lean muscle preservation while reducing fat mass.

Our company is a modern advanced enterprise specializing in production and exportation of APIs, Pharmaceutical intermediates, plant extracts etc. Our products are widely used in medicine, health care products, cosmetics, nutritional supplements and food additives areas. Our factory covers an area of 95 acres, the proposed construction of the plant will be GMP standards, the factory environment clean and tidy, rational layout, with large and medium-sized production workshop and repocessed shop. It is equipped with advanced equipment quality inspection and research center. Those products of both quality and technical content have reached the domestic advanced level. Since its establishment, the company has attached great importance to the team training and technical reform. Our modern production equipment guarantees for a fast and effective production with a superior degree of accuracy throughout the whole production line, everything is done in-house, processing, extraction, packaging and transportation of all links, ensuring maximum quality and efficiency. We are constantly research and development new ingredients and innovative new products, have earned the respect & Admiration from the worldwide customers. After years of continuous development, company has been accumulated rich experience in international trade and customer resources, established a stable customer base and perfect marketing service network. In addition, the company has established long-term technical cooperation with experts and professors from many universities and research institutes in the province.