Ferulic Acid Methyl Ester 98% Purity Natural Antioxidant Cosmetic Raw Material Food Additive Pharmaceutical Intermediate CAS 2309-07-1 Research Grade

Product Overview

Ferulic acid methyl ester (methyl 4-hydroxy-3-methoxycinnamate) is the methyl ester derivative of ferulic acid, a naturally occurring phenolic compound widely distributed in the plant kingdom. This esterified form is found naturally in various plant sources and essential oils, where it contributes to the characteristic aroma and antioxidant properties of these materials. The methyl ester modification enhances the lipophilic characteristics of the molecule, improving solubility in organic solvents and oils while maintaining the beneficial antioxidant activities of ferulic acid.

Chemically, ferulic acid methyl ester is designated as methyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate, bearing the molecular formula C₁₁H₁₂O₄ and a molecular weight of 208.21 g/mol. It is a white to off-white crystalline powder, readily soluble in ethanol, methanol, ethyl acetate, and chloroform, with limited aqueous solubility. The compound exhibits characteristic UV absorption maxima at 236 nm and 322 nm in methanol solution.

Our product is supplied at a minimum purity of 98.0% as determined by HPLC with photodiode array detection, with each batch accompanied by comprehensive Certificate of Analysis including HPLC chromatograms and spectral data.

Synthetic Process

Ferulic acid methyl ester is synthesized via Fischer esterification of ferulic acid with methanol under acidic catalysis. The reaction proceeds under reflux conditions, followed by isolation, purification by recrystallization, and comprehensive quality control including HPLC purity analysis and structural confirmation.

Mechanism of Action

Ferulic acid methyl ester exerts its biological activities through mechanisms closely related to those of ferulic acid:

• Free Radical Scavenging: The phenolic hydroxyl group provides potent hydrogen-donating capacity for neutralizing reactive oxygen species.

• Lipid Phase Antioxidant Activity: The methyl ester enhances lipophilicity, enabling effective partitioning into lipid bilayers and oil phases for protection against lipid peroxidation.

• UV Radiation Protection: The conjugated π-electron system provides intrinsic UV absorption in the UV-B and UV-A ranges.

• Synergistic Antioxidant Effects: Demonstrates synergistic activity when combined with other phenolic antioxidants and vitamins.

Research Applications & Market Significance

• Cosmetics and Personal Care: Anti-aging formulations, sunscreens, and moisturizers

• Food Preservation: Natural antioxidant in oils, fats, and processed foods

• Pharmaceutical Research: Pharmaceutical intermediate and research compound

• Flavor and Fragrance: Flavoring agent and fragrance component

• Analytical Standards: Reference material for HPLC and MS analysis

Quality Specifications

• Purity: ≥98.0% by HPLC-DAD

• Melting point: 78-80°C

• Water content: ≤0.5%

• Heavy metals: ≤10 ppm

• Residual solvents: Meets ICH Q3C guidelines

• Stability: 36 months at 2-8°C protected from light

Packaging & Shipping

• Analytical standards: 20mg amber glass vials

• Research quantities: 100mg, 500mg, 1g, 5g, 25g

• Standard shipments at ambient temperature with desiccant

• International shipping with MSDS and COA documentation

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.