Product Overview
Octacosyl (E)-ferulate is a naturally occurring long-chain alkyl ester of ferulic acid, featuring a ferulic acid moiety esterified with an octacosyl (C28) fatty alcohol chain. The compound has the molecular formula C₃₈H₆₆O₄ and a molecular weight of approximately 586.9 g/mol. It exists predominantly in the (E)-configuration, which is the thermodynamically favored form and the one most commonly found in natural sources.
This compound is a minor but significant constituent of plant cuticular waxes, seed oils, and root extracts, particularly in species of the families Apiaceae, Poaceae, and Asteraceae. Its high lipophilicity, conferred by the extended C28 alkyl chain, allows it to function as a long-term storage form of ferulic acid in lipid-rich plant tissues and as a component of protective epicuticular wax layers. As a high-purity reference standard, it is essential for the accurate identification and quantification of ferulic acid derivatives in complex botanical matrices.
Natural Sources and Biosynthesis
Octacosyl (E)-ferulate is biosynthesized via the esterification of ferulic acid, a phenylpropanoid-derived hydroxycinnamic acid, with octacosanol (C28 primary alcohol). This enzymatic esterification is catalyzed by acyltransferases in plant cells. The compound has been identified in various medicinal plants, including Angelica sinensis (Dong Quai), Ligusticum chuanxiong, and cereal grains such as wheat and rice bran, where it contributes to the lipophilic antioxidant pool.
The (E)-configuration is the naturally occurring form, resulting from the biosynthetic pathway that preferentially produces the trans-isomer of ferulic acid prior to esterification.
Biological Activities and Research Applications
As a lipophilic ferulic acid derivative, octacosyl (E)-ferulate exhibits biological activities that are largely attributable to the ferulic acid moiety:
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Antioxidant Defense: The phenolic hydroxyl group provides potent free radical scavenging activity, protecting lipid membranes from peroxidation
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Anti-inflammatory Properties: Modulates inflammatory pathways through inhibition of COX-2 and pro-inflammatory cytokine expression
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Skin Barrier Enhancement: As a component of plant waxes, it may contribute to skin barrier function and moisturization in topical applications
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Antimicrobial Activity: Demonstrates moderate activity against certain Gram-positive bacteria and fungi
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Neuroprotective Potential : Preliminary research suggests possible protective effects against oxidative neuronal damage
This product is intended exclusively for research applications, including analytical method development, pharmacological screening, and natural product chemistry studies. It is not for human consumption.
Quality Specifications
Our Octacosyl (E)-ferulate is produced under rigorous quality control standards:
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Purity: ≥98.0% determined by HPLC area normalization
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Identity confirmed by NMR (¹H, ¹³C) and high-resolution mass spectrometry
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(E)-Configuration confirmed by characteristic NMR coupling constants (J = 15-16 Hz)
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Free ferulic acid: ≤1.0%
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Water content: ≤0.5% (Karl Fischer)
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Each batch supplied with comprehensive Certificate of Analysis (COA)
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Stable for 24 months when stored at -20°C in sealed, light-protected containers
Packaging & Shipping
We offer flexible packaging solutions for research requirements:
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Research quantities: 2mg, 5mg, 10mg amber glass vials
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Custom packaging available upon request
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Shipped at ambient temperature with desiccant
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International shipping with full documentation available
Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.
Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.
We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.
To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.
Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.
