Guaijaverin 98% Purity Natural Product Reference Standard Flavonoid Glycoside High-Purity Research Material CAS 22255-13-6 for Phytochemical and Pharm

Product Overview

Guaijaverin, also known as quercetin-3-O-α-L-arabinopyranoside, is a naturally occurring flavonoid glycoside isolated from various medicinal plants, most notably from the leaves of the guava tree (Psidium guajava), from which its common name is derived. Chemically, it consists of the flavonol aglycone quercetin glycosidically linked to an α-L-arabinopyranosyl sugar moiety at the 3-position. The compound has the molecular formula C₂₀H₁₈O₁₁ and a molecular weight of approximately 434.4 g/mol.

Guaijaverin is recognized as one of the major bioactive flavonoid constituents in guava leaves and other plant sources. It is widely employed in phytochemical analysis, quality control of botanical extracts, and pharmacological research due to its diverse biological activities, particularly its antioxidant, anti-inflammatory, and antimicrobial properties.

Natural Sources and Biosynthesis

Guaijaverin is biosynthesized through the phenylpropanoid and flavonoid pathways, involving the glycosylation of quercetin with UDP-arabinose catalyzed by flavonoid glycosyltransferases. The compound has been identified in several plant species, including:

• Psidium guajava (Guava) – leaves

• Vaccinium corymbosum (Blueberry) – fruits

• Camellia sinensis (Tea) – leaves

• Ginkgo biloba (Ginkgo) – leaves

• Various species of the Myrtaceae and Ericaceae families

Guava leaves are considered a rich natural source of guaijaverin, along with other quercetin glycosides, and are traditionally used in herbal medicine for their health-promoting properties.

Biological Activities and Research Applications

Guaijaverin exhibits a wide range of biological activities that make it a compound of significant research interest:

• Antioxidant Activity: Exhibits potent free radical scavenging activity (DPPH, ABTS, and superoxide radicals), protecting cells against oxidative stress-induced damage

• Anti-inflammatory Effects : Inhibits pro-inflammatory mediators (COX-2, iNOS, TNF-α, IL-6, IL-1β) through modulation of NF-κB and MAPK signaling pathways

• Antimicrobial Activity : Demonstrates broad-spectrum antimicrobial effects against pathogenic bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa

• Antidiabetic Potentia l: Shows inhibitory activity against α-glucosidase and α-amylase, suggesting potential benefits in blood glucose regulation

• Cardioprotective Effects: Protects against oxidative damage to cardiac tissues and may help prevent cardiovascular diseases

• Anticancer Activity : Inhibits cancer cell proliferation and induces apoptosis in various cancer cell lines

• Gastroprotective Properties: Exhibits protective effects against gastric ulcers through antioxidant and anti-inflammatory mechanisms

This product is intended exclusively for research purposes and is not for human consumption.

Quality Specifications

Our Guaijaverin is manufactured under rigorous quality control standards:

• Purity: ≥98.0% determined by HPLC area normalization

• Identity confirmed by NMR (¹H, ¹³C) and high-resolution mass spectrometry

• Water content: ≤1.0% (Karl Fischer)

• Residual solvents: Meet ICH Q3C guidelines

• Each batch supplied with comprehensive Certificate of Analysis (COA)

• Stable for 24 months when stored at -20°C in sealed, light-protected containers

Packaging & Shipping

We offer flexible packaging options for research requirements:

• Research quantities: 5mg, 10mg, 20mg amber glass vials

• Custom packaging available upon request

• Shipped at ambient temperature for routine orders

• International shipping with full documentation available

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

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We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

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