Columbianadin 98% Purity Coumarin Standard CAS 5058-13-9 Research Grade Reference Standard

• • • • Product Overview

        Columbianadin is a naturally occurring coumarin found in the roots of Angelica species, particularly Angelica pubescens and Peucedanum species. It is the angelic acid ester of columbianetin and serves as an important reference standard for the quality control of Angelica products.

        With the molecular formula C₁₉H₂₀O₅ and a molecular weight of 328.36 g/mol, this compound appears as a white to off-white crystalline powder. It is soluble in methanol, ethanol, and DMSO. The product is supplied at ≥98% purity as determined by HPLC analysis.

        Synthetic Process

        Columbianadin is obtained through isolation from plant sources:

        1. Extraction: Angelica roots are extracted with organic solvents.

        2. Chromatographic Separation: The extract is fractionated using silica gel column chromatography.

        3. Purification: Preparative HPLC or recrystallization yields the pure compound.

        4. Identity Confirmation: Structure is confirmed by NMR and mass spectrometry.

        Mechanism of Action & Applications

        This compound is primarily used as:

        • Reference Standard: For the quantification of coumarins in Angelica products.

        • Quality Control: Used in the quality assessment of traditional Chinese medicines.

        • Natural Product Chemistry: Serves as a reference for coumarin identification.

        Quality Specifications

        • Purity: ≥98.0% determined by HPLC.

        • Identity: Confirmed by NMR and mass spectrometry.

        • Loss on Drying: ≤1.0%.

        • Each batch is accompanied by a comprehensive COA.

        • Stable for 24 months when stored at 2-8°C in sealed containers, protected from light.

        Packaging & Storage

        • Standard packaging: 5mg, 10mg, 20mg amber glass vials.

        • Store at 2-8°C, protected from light and moisture.

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.