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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Cilnidipine for Sale > Cilnidipine CAS 132203-70-4 L/N-Type Calcium Channel Blocker for Hypertension and Cardiovascular hfd
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Cilnidipine CAS 132203-70-4 L/N-Type Calcium Channel Blocker for Hypertension and Cardiovascular hfd

TDS

Unit Price: Get Latest Price
CAS No.:

132203-70-4

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

5g, 25g, 100g, 500g

Sample Available:

Yes

Price valid (until):

2026-09-26

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
7 days
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Cilnidipine  FRC-8653
    CAS Number 132203-70-4 132203-70-4 
    Molecular Formula C₂₇H₂₈N₂O₇ — 
    Molecular Weight 492.52 g/mol — 
    Appearance Solid Visual inspection
    Purity ≥98.0% Determined by HPLC 
    Melting Point 105 – 110°C — 
    Storage Cool, dry place, sealed container Protect from light and moisture
    Packaging 10mg, 25mg, 50mg, 100mg, 500mg, 1g Amber glass vials
    Application Research use only Cardiovascular research, calcium channel studies


    —— Product Detail ——

    Product Overview

    • Cilnidipine (CAS 132203-70-4), also known as FRC-8653, is a dihydropyridine derivative that functions as a long-acting dual antagonist of both L-type and N-type calcium channels . It appears as a solid with the molecular formula C₂₇H₂₈N₂O₇ and a molecular weight of 492.52 g/mol . Its IUPAC name is 3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propenyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate .


    Packaging & Shipping

                  • Research quantities: 5mg, 10mg, 25mg amber glass vials

                  • Bulk quantities: 50mg, 100mg amber glass bottles

                  • Custom packaging available upon request

                  • Not classified as hazardous material for transport under normal conditions

                  • Product for research and analytical use only; not for human therapeutic use

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    — Company profile ——


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    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    Yellow Crystalline SolidChEBI: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.Clinidipine is a kind of calcium channel blocker. It is a kind of novel calcium antagonist with the blocking effect on both L-type and N-type calcium channels. It is mainly used for the treatment of hypertension. Based on its effect on both N-type and L-type calcium channel, it can dilate both arterioles and venules, further reducing the pressure
    Cilnidipine is a diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive. It has a role as a calcium channel blocker, an antihypertensive agent and a cardiovascular drug. It is a dihydropyridine, a 2-methoxyethyl ester and a C-nitro compound.|Cilnidipine is a dihydropyridine calcium antagonist. It was jointly developed by Fuji Viscera Pharmaceutical Company, Japan and Ajinomoto, Japan and approved in 1995. Compared with other calcium antagonists, cilnidipine can act on the N-type calcium channel that existing sympathetic nerve end besides acting on L-type calcium channel that similar to most of the calcium antagonists. This drug is approved in China, Japan, Korea, India, and several countries in the European Union.

    Certificates
    • Cilnidipine CAS 132203-70-4 L/N-Type Calcium Channel Blocker for Hypertension and Cardiovascular hfd Certificates 1 TDS

    Basic Info
    Product Name:

    Cilnidipine

    Other Name:

    3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] ester;3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-methoxyethyl 3-phenyl-2-propenyl ester,(E)-(±)-;3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-methoxyethyl (2E)-3-phenyl-2-propenyl ester;(±)-FRC 8653;FRC 8653;Cilnidipine;Atelec;Cinalong;Siscard;3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-methoxyethyl 3-phenyl-2-propenyl ester,(E)-;FRG 8653;Cinaldipine;Cilacar 10;153220-67-8

    CAS No.:

    132203-70-4

    Molecular Formula:

    C27H28N2O7

    InChIKeys:

    InChIKey=KJEBULYHNRNJTE-DHZHZOJONA-N

    Molecular Weight:

    492.52

    Exact Mass:

    492.52

    EC Number:

    1806241-263-5

    UNII:

    S85436ZG85|4LNU2SU262

    DSSTox ID:

    DTXSID0046309

    ATC Code:

    C - Cardiovascular system

    HScode:

    29333990

    Characteristics
    PSA:

    120

    XLogP3:

    4.4

    Appearance:

    light yellow

    Density:

    1.240±0.06 g/cm3(Predicted)

    Melting Point:

    115.5-116.6 °C

    Boiling Point:

    653ºC

    Flash Point:

    348.5±31.5 °C

    Refractive Index:

    1.592

    Water Solubility:

    H2O: Insoluble

    Storage Conditions:

    Store at +4°C

    Vapor Pressure:

    0mmHg at 25°C

    Toxicity:

    LD50 in male, female mice, rats (mg/kg): 5000, 5000, 5000, 4412 orally; 5000 all species s.c.; 1845, 2353, 441, 426 i.p. (Wada)

    PKA:

    11.39None

    Dissociation Constants:

    11.39

    Hazard Identification

    Classification of the substance or mixture

    Serious eye damage, Category 1

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H318 Causes serious eye damage

    Precautionary statement(s)
    Prevention

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    Response

    P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P317 Get medical help.

    Storage

    none

    Disposal

    none

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7 days

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Country Product Purchase Quantity Date Posted
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