Full Name: Crystagen (Glu-Asp-Pro Tripeptide Bioregulator) Amino Acid Sequence: H-Glu-Asp-Pro-OH Molecular Formula: C₁₄H₂₁N₃O₈ Molecular Weight: 359.33 g/mol CAS Number: Unassigned custom synthetic peptide Appearance: Sterile lyophilized white crystalline powder, individually sealed in vials (main specifications: 10mg / 20mg / 50mg) Purity: ≥99% verified via HPLC, full COA quality inspection records provided for each batch R&D Background: Crystagen is a short synthetic tripeptide developed by the Saint Petersburg Institute of Bioregulation and Gerontology under Professor Vladimir Khavinson’s peptide bioregulator research system. It is extracted from the core active functional fragment of thymic polypeptide Thymalin, classified as a cytogen immune regulatory peptide. This high-purity laboratory-grade raw material is designed for thymic epithelial cell cultivation, T lymphocyte developmental testing, immunosenescence exploration and radiation-induced immune damage cell model research, widely applied in thymic immunology, epigenetic gene regulation and gerontological laboratory projects.

Crystagen penetrates immune cell nuclei and binds to specific promoter segments of target genes, activating dual epigenetic and thymic developmental regulatory networks within cell and tissue culture systems: Interact with chromatin and DNA promoter regions of immune-related genes to loosen condensed silent genetic segments, reactivate transcription programs suppressed during cell aging and restore normal protein synthesis in aged thymic cells; Stimulate proliferation activity of thymic epithelial stromal cells, maintain complete cortical-medulla structural integrity of thymic tissue under long-term culture environments and protect thymic tissue architecture from degenerative changes; Restrain excessive programmed cell loss of immature thymic precursor cells, elevate expression of proliferation-related markers to expand viable progenitor cell populations for orderly T cell differentiation; Adjust balanced secretion of core immune cytokines such as IL-2, standardize the proportion of CD3+, CD4+ and CD8+ lymphocyte subgroups and rebuild stable CD4+/CD8+ ratio within immune tissue samples; Increase survival quantity of macrophages and auxiliary immune cells inside thymic tissue co-culture systems, strengthen the overall antigen recognition and signal transmission capacity of immune microenvironment; Mitigate persistent oxidative and inflammatory stress damage triggered by external harmful stimulation including radiation exposure, reduce cumulative structural impairment of thymic and peripheral immune cells.

Core experimental probe to observe thymic stromal cell proliferation and tissue structural maintenance; suitable for organotypic thymic tissue culture and morphological quantitative detection assays.

Key raw material for exploring thymocyte differentiation trajectories and immune cell proportion adjustment, supporting lymphocyte phenotype identification and cytokine secretion quantitative testing experiments.

Auxiliary testing material for analyzing chromatin remodeling and age-related immune gene silencing reversal, applied to senescent thymic cell epigenetic profiling and lifespan-related immune function recovery studies.

Relieve degenerative changes of thymic tissue under simulated radiation or chronic stress culture conditions, support mechanism exploration of immune reconstruction after tissue injury.

Normalize disordered cytokine output from overactive immune cells, suited for cell-level experiments simulating low immune activity and persistent inflammatory immune dysfunction.

Supplied as sterile lyophilized white crystalline powder with HPLC-tested purity ≥99%, mainstream vial specifications include 10mg, 20mg and 50mg. Every batch comes with complete supporting documents including COA, MSDS and HPLC chromatogram test data.

As a thymus-targeted short tripeptide bioregulator reagent, Crystagen integrates epigenetic gene modulation and multi-layer thymic developmental protection functions. Its compact three-amino-acid chain delivers outstanding cell permeability and consistent target binding performance across diverse in vitro thymic cell and organotypic tissue co-culture research systems.

It serves as indispensable research material for cell cultivation and tissue model experiments covering thymic immunocyte development, epigenetic transcriptional regulation, radiation immune damage repair and age-related immune function decline biology.

Note: For laboratory research use only, not approved for human oral consumption or clinical therapeutic treatment.

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