niclosamide CAS.50-65-7
3 Inquiries
50-65-7
Pharmaceutical Grade
99%
Shenzhen
Flying
10g/1kg/ 10kg/ 25kg
2026-09-27
vitamin
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceNiclosamide is an inhibitor of STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.
Solid
Niclosamide is a secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections. It has a role as a piscicide, a molluscicide, an antiparasitic agent, an anticoronaviral agent, an anthelminthic drug, an apoptosis inducer and a STAT3 inhibitor. It is a member of monochlorobenzenes, a member of salicylanilides, a C-nitro compound, a secondary carboxamide and a member of benzamides. It derives from a 5-chlorosalicylic acid.|Niclosamide is an antihelminthic used for the treatment of tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an even greater problem in domestic animals. Niclosamide, once marketed in the US under the brand name Niclocide, was voluntarily withdrawn from market by Bayer in 1996.|Niclosamide is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Upon oral administration, niclosamide specifically induces degradation of the androgen receptor (AR) variant V7 (AR-V7) through the proteasome-mediated pathway. This downregulates the expression of the AR variant, inhibits AR-V7-mediated transcriptional activity, and reduces AR-V7 recruitment to the prostate-specific antigen (PSA) gene promoter. Niclosamide also prevents AR-V7-mediated STAT3 phosphorylation and activation. This inhibits AR/STAT3-mediated signaling and prevents expression of STAT3 target genes. Altogether, this may inhibit growth of AR-V7-overexpressing cancer cells. The AR-V7 variant, which is encoded by contiguous splicing of AR exons 1/2/3/CE3, is upregulated in a variety of cancer cell types, and is associated with both cancer progression and resistance to AR-targeted therapies.|An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)Basic Info-
Product Name:
Niclosamide
Other Name:Benzamide,5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-;Salicylanilide,2′,5-dichloro-4′-nitro-;5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide;Bayluscid;5-Chloro-2′-chloro-4′-nitrosalicylanilide;N-(2-Chloro-4-nitrophenyl)-5-chlorosalicylamide;2′,5-Dichloro-4′-nitrosalicylanilide;HL 2447;2-Hydroxy-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide;Iomesan;Niclosamide;Phenasal;Vermitin;Yomesan;2-Chloro-4-nitrophenylamide-6-chlorosalicylic acid;Fenasal;N-(2′-Chloro-4′-nitrophenyl)-5-chlorosalicylamide;Mansonil;Radeverm;5-Chloro-N-(2′-chloro-4′-nitrophenyl)salicylamide;Bayer 2353;Lintex;Nasemo;Sulqui;Tredemine;Sagimid;Devermin;Devermine;Cestocid;Mato;Vermitid;Helmiantin;Fedal-Telmin;BAY 2353;Zestocarp;WR 46234;Utosamide;Niclocide;Cestocide;Ruby;NSC 178296;12687-52-4
CAS No.:50-65-7
Molecular Formula:C13H8Cl2N2O4
InChIKeys:InChIKey=RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Molecular Weight:327.12
Exact Mass:327.12
EC Number:200-056-8
UNII:8KK8CQ2K8G
NSC Number:758440|178296
DSSTox ID:DTXSID7040362
NCI Thesaurus Code:C66240
Color/Form:PALE, YELLOW CRYSTALS|ALMOST COLORLESS CRYSTALS|A cream-colored or yellowish-white powder|Bright yellow crystalline solid
ATC Code:P02DA01|P - Antiparasitic products, insecticides and repellents
HScode:2924299090
Categories:
Characteristics-
PSA:
95.2
XLogP3:10 @ pH 9.6
Appearance:Solid
Density:1.6±0.1 g/cm3
Melting Point:225-230 °C
Boiling Point:424.5±45.0 °C at 760 mmHg
Flash Point:210.5±28.7 °C
Refractive Index:1.709
Water Solubility:acetone: methanol: soluble 50mg/mL (methanol:acetone (1:1))
Storage Conditions:0-6°C
Vapor Pressure:<9.87X10-9 mm Hg at 20 deg C
Toxicity:Oral-Rat LD50: 2500 mg/kg; Oral-Mouse LD50: 1000 mg/kg
Flammability characteristics:Combustion produces toxic chloride and nitrogen oxide gases
Taste:Tasteless
Experimental Properties:Hydrolysed in aqueous solution with a decomposition half-life at 20 °C of 7 days (pH 6.9), 18.8 days (pH 13.3). Stable to heat. Decomposes under UV irradiation. Hydrolysed by concentrated acid or alkali.|Decomposes at 208 °C|Its biological effectiveness in water is stable at pH 5-9 and is also largely independent of the concentration of calcium and magnesium ions.
Hazard IdentificationClassification of the substance or mixture
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H400 Very toxic to aquatic life
Precautionary statement(s) Prevention P273 Avoid release to the environment.
Response P391 Collect spillage.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
stored at a temp less than 30 deg C; freezing of the tablets should be avoided.
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Seller Information
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Business Type:
Trader
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Main Products:
vitamin
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Location:
Room 2-502, Building 6, Luneng Tehran Garden Building, No.8 Changbin Road, Xiuying district, Haikou City, Hainan Province
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment
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Average lead Time:
25
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
Less than 5
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Year of Establishment:
2023
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Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted 
Jordan
Niclosamide
1000 KG Aug 29, 2024 
China
Niclosamide
1 MT Jun 18, 2026 
United Kingdom
niclosamide
1 MG Mar 6, 2026 Post an enquiry for this product
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