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Isorhamnetin-3-O-neohesperidoside 98% Purity CAS 55033-90-4 Research Grade Flavonoid Glycoside Reference Standard for Natural Product Analysis

Unit Price:

$45-50/G FOB

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CAS No.:

55033-90-4

Grade:

Research Grade

Content:

99%

Port:

Qingdao

Brand:

Packaging:

20mg/vial

Sample Available:

Yes

Price valid (until):

2026-10-01

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Jinan topfull chemical co.,ltd

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

7 days

Qualification:

Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

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Product Description
Seller Information

Description

Shop Isorhamnetin-3-O-neohesperidoside 98% Purity CAS 55033-90-4 Research Grade Flavonoid Glycoside Reference Standard for Natural Product Analysis-Detailed Image 1

Product Overview

Isorhamnetin‑3‑O‑neohesperidoside (CAS 55033‑90‑4) is a high‑purity flavonoid glycoside reference standard consisting of isorhamnetin as the aglycone, with a neohesperidoside sugar moiety attached at the 3‑position. Neohesperidoside is a disaccharide composed of rhamnose and glucose linked via an α‑1→2 glycosidic bond. This compound is widely distributed in citrus fruits and various medicinal plants. It exhibits significant biological activities including antioxidant, anti‑inflammatory, and cardiovascular protective effects. As a reference standard, it is essential for the qualitative and quantitative analysis of flavonoid glycosides in botanical extracts, food products, and pharmaceutical formulations using HPLC and LC‑MS methods.

Synthetic Process / Isolation Method

Isorhamnetin‑3‑O‑neohesperidoside is isolated from natural plant sources:

Extraction: Plant materials (such as citrus peels, Ginkgo biloba leaves, or sea buckthorn) are extracted with hydroalcoholic solvents.
Partitioning: The crude extract is partitioned to separate glycosylated flavonoids from aglycones and other compounds.
Chromatographic Purification: The glycoside fraction undergoes repeated column chromatography using polyamide, Sephadex LH‑20, or preparative HPLC.
Recrystallization: Pure fractions are recrystallized to achieve ≥98% purity.
Quality Confirmation: Characterized by HPLC, NMR, and MS.

Mechanism of Action

Antioxidant Activity: The glycoside retains the antioxidant capacity of the isorhamnetin aglycone, with the sugar moiety potentially enhancing solubility and bioavailability.
Cardiovascular Protection: Improves endothelial function and reduces oxidative stress, contributing to the cardioprotective effects of flavonoid‑rich plant extracts.

Anti‑inflammatory Activity: Modulates inflammatory responses through the regulation of cytokine production and inflammatory signaling pathways.

Parameter	Specification	Details
Product Name	Isorhamnetin‑3‑O‑neohesperidoside	Flavonoid glycoside reference standard
CAS Number	55033‑90‑4	55033‑90‑4
Molecular Formula	C₂₈H₃₂O₁₆	28 carbons, 32 hydrogens, 16 oxygens
Molecular Weight	624.55 g/mol	—
Appearance	Yellow powder	Visual inspection
Assay (Purity)	≥98.0%	HPLC area normalization
Chemical Class	Flavonoid glycoside	Neohesperidoside type
Storage Condition	2‑8°C, protected from light, sealed, dry	Store in a cool, dry place
Shelf Life	24 months	From date of manufacture
Packaging	20mg/vial	Amber glass vial
Grade	Research Grade / Reference Standard	For laboratory and analytical use

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Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers .

ECHEMI Editorial Reference

Isorhamnetin-3-O-neohespeidoside is a flavonoid isolated from Pollen typhae[1].

Basic Info

Product Name:

Isorhamnetin 3-O-neohesperidoside

Other Name:

4H-1-Benzopyran-4-one,3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-;3-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one;Isorhamnetin 3-O-neohesperidoside;Calendoflavoside;Isorhamnetin 3-O-neohesperoside;Isorhamnetin 3-O-neohesperidin;ISORHAMNETIN-3-neohesperidoside;215457-34-4

CAS No.:

55033-90-4

Molecular Formula:

C28H32O16

InChIKeys:

InChIKey=QHLKSZBFIJJREC-SPSUIZEHSA-N

Molecular Weight:

624.54408

Exact Mass:

624.54

Categories:

Flavonoids

Characteristics

PSA:

255

XLogP3:

-0.4

Density:

1.7±0.1 g/cm3

Boiling Point:

956.8°C at 760 mmHg

Flash Point:

314.2±27.8 °C

Refractive Index:

1.728

See More Isorhamnetin 3-O-neohesperidoside Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Isorhamnetin 3-O-neohesperidoside Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

Location:
RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7 days

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
11-50

Year of Establishment:
2022

Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
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Isorhamnetin-3-O-neohesperidoside 98% Purity CAS 55033-90-4 Research Grade Flavonoid Glycoside Reference Standard for Natural Product Analysis

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

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