slupp915 99% high purity

SLU-PP-915 (CAS 2285432-92-8) is a high-purity, second-generation synthetic small-molecule pan-ERR agonist specially developed for advanced pharmaceutical and biochemical research. With the molecular formula C₁₇H₁₃BFNO₃S and molecular weight 341.16, this compound features an optimized chemical structure that effectively solves the metabolic defects of early ERR agonists. Compared with traditional analogues, SLU-PP-915 possesses significantly improved bioavailability and structural stability, ensuring reliable and repeatable experimental performance in long-term biological testing. All products are manufactured under standardized purification procedures, with HPLC purity up to ≥99%, low moisture content and stable physical and chemical properties, which fully meets the strict quality requirements of academic laboratories and pharmaceutical R&D institutions.

As a potent pan-estrogen-related receptor agonist, SLU-PP-915 can efficiently activate three key subtypes including ERRα, ERRβ and ERRγ, with a typical EC50 value of approximately 400 nM. It prominently enhances ERR-mediated transcriptional activation and effectively upregulates the expression of core genes related to mitochondrial biosynthesis, fatty acid metabolism and oxidative energy metabolism. The compound plays a crucial regulatory role in improving cellular energy supply, repairing mitochondrial dysfunction and optimizing metabolic homeostasis. It is widely recognized as a core tool compound for studying energy metabolism regulation, mitochondrial biology mechanism and metabolic signal pathway exploration in life science research.

SLU-PP-915 has become a mainstream research reagent in multiple cutting-edge research fields. It is extensively applied in preclinical mechanism research of cardiovascular diseases, especially in the study of heart failure improvement, cardiac energy metabolism remodeling and myocardial protective mechanisms. In addition, the compound is commonly used for metabolic syndrome research, exercise mimic mechanism exploration, new drug target screening and functional verification of metabolic regulatory pathways. It supports diversified experimental models including cell-level activity verification, animal model efficacy observation and pharmacological mechanism analysis, providing stable and credible raw material support for global biomedical research projects and new drug development programs.

To maintain long-term structural stability and biological activity, SLU-PP-915 requires sealed storage at -20℃ under dark and dry environment, avoiding repeated freezing and thawing to prevent activity attenuation. Under standard storage conditions, the powder product maintains stable quality for up to 24 months. We provide standardized packaging specifications from gram-level sample packages to kilogram-level bulk drums, supporting customized packaging and flexible batch supply. Every batch of products undergoes strict HPLC purity detection, moisture analysis and quality inspection before delivery, ensuring stable batch consistency. This product is only applicable for scientific laboratory research, prohibited for human body, food, cosmetic and clinical application.

Different from traditional ERR agonist analogs with poor solubility and low oral bioavailability, SLU-PP-915 adopts a newly optimized boronic acid derivative structure, which greatly improves compound solubility, formulation compatibility and in vivo absorption efficiency. This structural optimization effectively overcomes the defects of early-generation tool compounds that were only suitable for in vitro cell experiments and difficult for in vivo animal model administration. The excellent formulation performance enables SLU-PP-915 to be widely used in oral administration experiments, long-term metabolic intervention studies and in vivo pharmacological efficacy evaluation, making it a more ideal research tool for simulating exercise metabolism phenotypes and exploring nuclear receptor regulatory mechanisms in living organisms.

All batches of SLU-PP-915 are produced and inspected in strict accordance with ISO standardized quality control system, with full-process monitoring from raw material screening, synthetic reaction, purification recrystallization to finished product packaging. Each batch is accompanied with complete HPLC purity report, mass spectrometry identification, moisture detection and heavy metal residual test data to ensure consistent batch-to-batch stability and ultra-low impurity residue. The factory maintains stable large-scale production capacity and flexible inventory reserves, which can fully meet global customers’ demands for small sample trial purchase, medium batch experimental use and large-scale industrial pre-research bulk orders. Strict quality screening and standardized production management ensure that every delivered product can support high-precision scientific research data output and long-term project repetition verification.