Isradipine
75695-93-1
Pharma Grade
99%
DAHAI BIOCHEM
25kg/Cardboard Drum
2026-12-31
HARD FAT
-
Product Description
-
Seller Information
-
DescriptionECHEMI Editorial ReferenceIsradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.Target: Calcium ChannelIsradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack[1]. Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine a
Solid
Isradipine is an isopropyl ester, a methyl ester, a dihydropyridine and a benzoxadiazole.|Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension.|Isradipine is a second generation calcium channel blocker that is used to treat hypertension. Isradipine is associated with a low rate of serum enzyme elevations during therapy, but has not been linked convincingly to instances of clinically apparent liver injury.|A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.Basic Info-
Product Name:
Isradipine
Other Name:3,5-Pyridinedicarboxylic acid,4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-,3-methyl 5-(1-methylethyl) ester;3,5-Pyridinedicarboxylic acid,4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-,methyl 1-methylethyl ester;3,5-Pyridinedicarboxylic acid,4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-,methyl 1-methylethyl ester;2,1,3-Benzoxadiazole,3,5-pyridinedicarboxylic acid deriv.;Isradipin;Isradipine;PN 200-110;Lomir;PN 200;(±)-Isradipine;DynaCire;DynaCire CR;Esradin;Clivoten;Prescal;Rebriden;Isrodipine;DynaCirc;Dynacrine;3-O-Methyl 5-O-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;88977-22-4
CAS No.:75695-93-1
Molecular Formula:C19H21N3O5
InChIKeys:InChIKey=HMJIYCCIJYRONP-UHFFFAOYSA-N
Molecular Weight:371.39
Exact Mass:371.39
EC Number:1308068-626-2
NSC Number:759892
DSSTox ID:DTXSID4023179
ATC Code:C - Cardiovascular system
HScode:2934990002
Categories:
Characteristics-
PSA:
104
XLogP3:4.3
Appearance:yellow solid
Density:1.3±0.1 g/cm3
Melting Point:168-170 °C
Boiling Point:501.9ºC at 760 mmHg
Flash Point:257.4±32.9 °C
Refractive Index:1.566
Water Solubility:H2O: Practically insoluble (< 10 mg/L at 37 °C);DMSO: ~26 mg/mL
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Eye irritation, Category 2
Specific target organ toxicity â repeated exposure, Category 1
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H319 Causes serious eye irritation
H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P319 Get medical help if you feel unwell.
P391 Collect spillage.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Trader
-
Main Products:
HARD FAT
-
Location:
BUILDING 4,NO.571, STR.19,BAIYANG DISTRICT, HANGZHOU,CHINA
-
Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
-
Total Annual Revenue:
Less than $1 million
-
Total Employees:
5-10
-
Year of Establishment:
2025
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product
